Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Timothy Lekin"'
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 11:7-15
An automated platform for low-volume, highthroughput protein crystallization by the sitting drop vapor diffusion has been developed. This platform consists of a novel Society of Biomolecular Screening standard microplate technology, standard automati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::145a534b2ca9f2721a7f84321cbb07f5
https://doi.org/10.1016/j.jala.2005.09.004
https://doi.org/10.1016/j.jala.2005.09.004
Autor:
Li-Wei Hung, Chang-Yub Kim, Beom-Seop Rho, Bernhard Rupp, Timothy Lekin, Jean-Denis Pedelacq, Thomas C. Terwilliger, Su-Il Kim, Brent W. Segelke, Geoffrey S. Waldo
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 62:563-569
The three-dimensional structure of Rv2607, a putative pyridoxine 5'-phosphate oxidase (PNPOx) from Mycobacterium tuberculosis, has been determined by X-ray crystallography to 2.5 A resolution. Rv2607 has a core domain similar to known PNPOx structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560eac085d4f30ca522ecbecbff1fad9
https://doi.org/10.1002/prot.20824
https://doi.org/10.1002/prot.20824
Autor:
Adam Zemla, Thomas C. Terwilliger, Brent W. Segelke, Min S. Park, Katherine A. Kantardjieff, Cleo Naranjo, Timothy Lekin, Chang Yub Kim, Geoffry S Waldo, Bernhard Rupp
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 60:895-902
The Mycobacterium tuberculosis rmlC gene encodes dTDP-4-keto-6-deoxyglucose epimerase, the third enzyme in the M. tuberculosis dTDP-l-rhamnose pathway which is essential for mycobacterial cell-wall synthesis. Because it is structurally unique, high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c7d1c1ee0135ac500ad24665b1ab26
https://doi.org/10.1107/s0907444904005323
https://doi.org/10.1107/s0907444904005323
Autor:
Neil A. Peterson, Timothy Lekin, Chang-Yub Kim, Li-Wei Hung, Edward N. Baker, Min Young Kim, Brent W. Segelke, Minmin Yu, J. Shaun Lott, Simon Li
Publikováno v:
Journal of molecular biology. 346(4)
All living systems require protection against the damaging effects of reactive oxygen species. The genome of Mycobacterium tuberculosis , the cause of TB, encodes a number of peroxidases that are thought to be active against organic and inorganic per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4af32dfdbada7a7c4c2fe15506d6f4
https://pubmed.ncbi.nlm.nih.gov/15701515
https://pubmed.ncbi.nlm.nih.gov/15701515
Autor:
Chang Yub Kim, Beom Seop Rho, Carolina Vasquez, Brent W. Segelke, Katherine A. Kantardjieff, Bernhard Rupp, Nancy M Warfel, Thomas C. Terwilliger, Peter Castro, Timothy Lekin
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 61(Pt 4)
The Mycobacterium tuberculosis pyrR gene (Rv1379) encodes a protein that regulates the expression of pyrimidine-nucleotide biosynthesis (pyr) genes in a UMP-dependent manner. Because pyrimidine biosynthesis is an essential step in the progression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c386a17b968a467e17ef489f707e3eeb
https://pubmed.ncbi.nlm.nih.gov/15805589
https://pubmed.ncbi.nlm.nih.gov/15805589
Autor:
Heike I. Krupka, Chang Yub Kim, Uhn-Soo Cho, Min Young Kim, Michael R. Sawaya, Brent W. Segelke, Jeanne Perry, Cleo Naranjo, Yvonne C. Rogers, Duilio Cascio, Geoffrey S. Waldo, Minyoung So, Inna Pashkov, Sum Chan, Min S. Park, Timothy Lekin
Publikováno v:
Journal of molecular biology. 341(2)
The structure of Mycobacterium tuberculosis dUTP nucleotidohydrolase (dUTPase) has been determined at 1.3 Angstrom resolution in complex with magnesium ion and the non-hydrolyzable substrate analog, alpha,beta-imido dUTP. dUTPase is an enzyme essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37e701fb6ee6c461528abf2d005472c
https://pubmed.ncbi.nlm.nih.gov/15276840
https://pubmed.ncbi.nlm.nih.gov/15276840