Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Timothy Leach"'
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Akademický článek
Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies
Autor: Timothy Leach, Uma Gandhi, Kimberly D. Reeves, Kristina Stumpf, Kenichi Okuda, Frank C. Marini, Stephen J. Walker, Richard Boucher, Jeannie Chan, Laura A. Cox, Anthony Atala, Sean V. Murphy
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The human airways are complex structures with important interactions between cells, extracellular matrix (ECM) proteins and the biomechanical microenvironment. A robust, well-differentiated in vitro culture system that accurately models thes
Externí odkaz: https://doaj.org/article/f6aec4b9509d461d8e54e25cfb50ccb8
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2
Organoid Technologies for SARS-CoV-2 Research
Autor: Khiry Sutton, Timothy Leach, Vikram Surendran, Phillip Clapp, Sean Murphy
Publikováno v: Current stem cell reports. 8(4)
Organoids are an emerging technology utilizing three-dimensional (3D), multi-cellular in vitro models to represent the function and physiological responses of tissues and organs. By using physiologically relevant models, more accurate tissue response
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1ccfb6e5c368205ac55a3191884be4
https://pubmed.ncbi.nlm.nih.gov/36313938
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3
Development of a Novel Air-Liquid Interface Airway Tissue Equivalent Model for In Vitro Respiratory Modeling Studies
Autor: Timothy Leach, Uma Gandhi, Kimberly D. Reeves, Kristina Stumpf, Kenichi Okuda, Frank C. Marini, Steve Walker, Jeannie Chan, Laura A. Cox, Anthony Atala, Sean V. Murphy
The human airways are complex structures with important interactions between cells, extracellular matrix (ECM) proteins and the biomechanical microenvironment. A robust, well-differentiated in vitro culture system that accurately models these interac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb5ba3a1878dc4a7c78f44330606d657
https://doi.org/10.1101/2022.09.21.508886
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4
Vedolizumab Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability Following Administration of a Single, Ascending, Intravenous Dose to Healthy Volunteers
Autor: Brian G. Feagan, I. Fox, Catherine Scholz, Timothy Leach, Tim Wyant, Maria Rosario, Serap Sankoh, Asit Parikh
Publikováno v: Clinical Drug Investigation. 36:913-923
Vedolizumab, a humanized monoclonal antibody against the α4β7 integrin, is indicated for treatment of moderately to severely active ulcerative colitis or Crohn’s disease. In this placebo-controlled, double-blind, randomized, single ascending-dose
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd5a921c511a15e8c84de3063f639c3
https://doi.org/10.1007/s40261-016-0437-4
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5
Occurrence of adverse events among patients with inflammatory bowel disease in the HealthCore Integrated Research Database
Autor: Jane Porter, Timothy Leach, Daina B. Esposito, Megan E. McAuliffe, Yueqin Zhao, Gerald Faich, Asit Parikh, Crystal N. Holick, Stephan Lanes, I. Fox
Publikováno v: Current Medical Research and Opinion. 31:1655-1664
Inflammatory bowel disease (IBD) is a chronic condition commonly requiring lifelong care. Both IBD and IBD-related treatments can cause significant morbidity, and it is often difficult to differentiate their relative etiologic contribution to adverse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd54548aad6160737c7341d535a17bdb
https://doi.org/10.1185/03007995.2015.1065242
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7
Vedolizumab for the Treatment of Active Ulcerative Colitis: A Randomized Controlled Phase 2 Dose-ranging Study
Autor: Timothy Leach, Diane R. Mould, Brian G. Feagan, I. Fox, Asit Parikh, Tim Wyant, Terry Ponich, Serap Sankoh, Catherine Scholz
Publikováno v: Inflammatory Bowel Diseases. 18:1470-1479
Background: Vedolizumab is a gut-selective biologic that has shown efficacy in ulcerative colitis (UC) and Crohn's disease (CD). We studied the pharmacokinetics, pharmacodynamics, safety, tolerability, and efficacy of a new formulation of vedolizumab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136296bfadcb821c2e5adee5d76d65fa
https://doi.org/10.1002/ibd.21896
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8
New approaches to Clostridium difficile colitis therapy
Autor: Timothy Leach, Bruce L. Rogers
Publikováno v: Drug Discovery Today: Therapeutic Strategies. 1:513-517
Clostrium difficile, a Gram-positive, spore-forming anaerobic bacillus, is one of the most common causes of hospital-acquired diarrhea. The two most important risk factors for C. difficile-associated diarrhea (CDAD) are recent exposure to an antibiot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3882492fa9648ac37715d80e5f35d4b0
https://doi.org/10.1016/j.ddstr.2004.11.001
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9
Performance Measurement and Scaling in Small Internal Combustion Engines
Autor: Christopher Cadou, Nathan Moulton, Moyo Aluko, Troy Sookdeo, Timothy Leach
Publikováno v: 41st Aerospace Sciences Meeting and Exhibit.
The development of a dynamometer system suitable for measuring the power output and efficiency of small internal combustion engines with masses less than 1 kg is described. These measurements are difficult because engine speeds are high ranging betwe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0db52c6f5d37d7ecb7e3e9e965a97ec
https://doi.org/10.2514/6.2003-671
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