Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Timothy L. Yahr"'
Autor:
Naren G. Kumar, Vincent Nieto, Abby R. Kroken, Eric Jedel, Melinda R. Grosser, Mary E. Hallsten, Matteo M. E. Mettrucio, Timothy L. Yahr, David J. Evans, Suzanne M. J. Fleiszig
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Within epithelial cells, Pseudomonas aeruginosa depends on its type III secretion system (T3SS) to escape vacuoles and replicate rapidly in the cytosol. Previously, it was assumed that intracellular subpopulations remaining T3SS-negative (an
Externí odkaz:
https://doaj.org/article/4c4628428ee34575b5086aef923761fc
Autor:
Sardar Karash, Timothy L. Yahr
Publikováno v:
mSystems, Vol 7, Iss 3 (2022)
ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen prevalent in the environment and in health care settings. Transmission in the health care setting occurs through human-human interactions and/or contact with contaminated surfaces. Moist su
Externí odkaz:
https://doaj.org/article/f0e562c682c145faabb699b9e0adecde
Autor:
Kimberly A. Coggan, Matthew G. Higgs, Evan D. Brutinel, Jeremiah N. Marden, Peter J. Intile, Hanne C. Winther-Larsen, Michael Koomey, Timothy L. Yahr, Matthew C. Wolfgang
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT The opportunistic pathogen Pseudomonas aeruginosa relies upon type IV pili (Tfp) for host colonization and virulence. Tfp are retractile surface appendages that promote adherence to host tissue and mediate twitching motility, a form of surfa
Externí odkaz:
https://doaj.org/article/5e005aff4a7f4d8cb04e84fbfbf5906f
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 1 (2021)
ABSTRACT Effector proteins translocated into host cells by the Pseudomonas aeruginosa type III secretion system (T3SS) are critical for phagocytic avoidance and systemic spread of the microorganism. The T3SS genes are present in virtually all P. aeru
Externí odkaz:
https://doaj.org/article/0e3406aedd17468482bf89969edb7339
Autor:
Kayley H. Janssen, Jodi M. Corley, Louise Djapgne, J. T. Cribbs, Deven Voelker, Zachary Slusher, Robert Nordell, Elizabeth E. Regulski, Barbara I. Kazmierczak, Emily Williams McMackin, Timothy L. Yahr
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen causing skin and soft tissue, respiratory, and bloodstream infections. The type III secretion system (T3SS) is one important virulence factor. Production of the T3SS is control
Externí odkaz:
https://doaj.org/article/be69f60c1b7f455f97431a12f9241e55
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Pseudomonas aeruginosa is internalized into multiple types of epithelial cell in vitro and in vivo and yet is often regarded as an exclusively extracellular pathogen. Paradoxically, ExoS, a type three secretion system (T3SS) effector, has an
Externí odkaz:
https://doaj.org/article/fed2cbe1a18146dbb4eaa4deb742abf0
Autor:
Naren G. Kumar, Vincent Nieto, Abby R. Kroken, Eric Jedel, Melinda R. Grosser, Mary E. Hallsten, Matteo M. E. Mettrucio, Timothy L. Yahr, David J. Evans, Suzanne M. J. Fleiszig
Publikováno v:
mBio, vol 13, iss 6
Within epithelial cells,Pseudomonas aeruginosadepends on its type three secretion system (T3SS) to escape vacuoles and replicate rapidly in the cytosol. Previously, it was assumed that intracellular subpopulations remaining T3SS-negative (and therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe524c36cae47467087f4f7d8be18cf
https://doi.org/10.1101/2022.10.07.511388
https://doi.org/10.1101/2022.10.07.511388
Autor:
Amir Rezayat, Timothy L. Yahr, S.L. Durfey, Jayanthi Garudathri, Matthew C. Radey, Ronald L. Gibson, Anina Ratjen, Peter Jorth, David A. Cook, Moira L. Aitken, Pradeep K. Singh, Benjamin J. Staudinger, Alan Genatossio, Sharon McNamara
Publikováno v:
Am J Respir Crit Care Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7460e4f9e260d057b270868af8def948
https://doi.org/10.1164/rccm.202007-2735le
https://doi.org/10.1164/rccm.202007-2735le
Publikováno v:
J Bacteriol
The Gac/Rsm system is a global regulator of Pseudomonas aeruginosa gene expression. The primary effectors are RsmA and RsmF. Both are RNA-binding proteins that interact with target mRNAs to modulate protein synthesis. RsmA/RsmF recognize GGA sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9437392dac096c17cd8a87c893634566
https://europepmc.org/articles/PMC8923221/
https://europepmc.org/articles/PMC8923221/
Autor:
Abby R. Kroken, Naren Gajenthra Kumar, Timothy L. Yahr, Benjamin E. Smith, Vincent Nieto, Hart Horneman, David J. Evans, Suzanne M. J. Fleiszig
Publikováno v:
PLoS pathogens, vol 18, iss 2
The Pseudomonas aeruginosa toxin ExoS, secreted by the type III secretion system (T3SS), supports intracellular persistence via its ADP-ribosyltransferase (ADPr) activity. For epithelial cells, this involves inhibiting vacuole acidification, promotin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bf6a55ceab8de2b24eb871129710fa
https://pubmed.ncbi.nlm.nih.gov/35130333
https://pubmed.ncbi.nlm.nih.gov/35130333