Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Timothy L. Foley"'
Autor:
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S. Chang, Stephen Noell, Timothy L. Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A. Piotrowski, Kathleen A. Farley, Tamara Gilbert, Lisa M. Aschenbrenner, Kimberly F. Fennell, Jason K. Dutra, Mary Xu, Chunyang Guo, Alison E. Varghese, Justin Bellenger, Alandra Quinn, Christopher W. am Ende, Graham M. West, Matthew C. Griffor, Donald Bennett, Matthew Calabrese, Claire M. Steppan, Seungil Han, Huixian Wu
Publikováno v:
Nature Structural & Molecular Biology. 30:22-30
Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis. Hepatic expression of GPAT1 is linked to liver fat accumulation and the severity of nonalcoholi
Autor:
Jonathan J Cherry, Christine J DiDonato, Elliot J Androphy, Alessandro Calo, Kyle Potter, Sara K Custer, Sarah Du, Timothy L Foley, Ariamala Gopalsamy, Emily J Reedich, Susana M Gordo, William Gordon, Natalie Hosea, Lyn H Jones, Daniel K Krizay, Gregory LaRosa, Hongxia Li, Sachin Mathur, Carol A Menard, Paraj Patel, Rebeca Ramos-Zayas, Anne Rietz, Haojing Rong, Baohong Zhang, Michael A Tones
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185079 (2017)
C5-substituted 2,4-diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS (DAQ-DcpSi) have been developed for the treatment of spinal muscular atrophy (SMA), which is caused by genetic deficiency in the Survival Motor Neuron (SMN) prote
Externí odkaz:
https://doaj.org/article/d509895517b840fca86c06c702f957d6
Publikováno v:
Biochemical and Biophysical Research Communications. 533:249-255
DEL selections are binding assays conducted with mixtures of chemically diverse DNA-tagged ligands and a screening target. DEL selections use DNA sequence counts to measure target binding, where ideally higher affinity ligands will have higher counts
Publikováno v:
Journal of chemical information and modeling. 62(9)
By analyzing data sets of replicate DNA-Encoded Library (DEL) selections, an approach for estimating the noise level of the experiment has been developed. Using a logarithm transformation of the number of counts associated with each compound and a su
Autor:
Timothy L. Foley, Anokha S. Ratnayake, Justin Bellenger, Brian M. Paegel, Mark Edward Flanagan, Jillian G. Johnson, Justin I. Montgomery, Justin Donald Smith
Publikováno v:
ACS Comb Sci
DNA-Encoded Chemical Library (DECL) synthesis must occur in aqueous media under conditions that preserve the integrity of the DNA encoding tag. While the identification of “DNA-compatible” reaction conditions is critical for the development of DE
Autor:
Kathleen A. Farley, Parag Sahasrabudhe, Manjinder S. Lall, Justin Bellenger, Bruce Allen Lefker, Xidong Feng, Timothy L. Foley, Scott L. Hultgren, Dominik K. Kölmel, Jinqiao Wan, Bo Liu, Justin I. Montgomery, Anokha S. Ratnayake, Mark Edward Flanagan, Shi Chen, Laura J. Byrnes, Andre Shavnya, Tim F. Ryder
Publikováno v:
Bioorganicmedicinal chemistry. 41
The ability to predict chemical structure from DNA sequence has to date been a necessary cornerstone of DNA-encoded library technology. DNA-encoded libraries (DELs) are typically screened by immobilized affinity selection and enriched library members
Autor:
Kevin Ogilvie, Timothy L. Foley, Erik Alphie Lachapelle, Jaimeen D. Majmudar, Zhen Huang, Jason K. Dutra, Justin Bellenger, Subham Mahapatra, Christopher W. am Ende, Ethan Lawrence Fisher, Butler Todd W
Publikováno v:
Chembiochem : a European journal of chemical biology. 22(10)
Herein, we report a general and simplified synthesis of fluorophosphonates directly from p-nitrophenylphosphonates. This FP on-demand reaction is mediated by a commercially available polymer-supported fluoride reagent that produces a variety (25 exam
Autor:
Qiuxia Chen, Kristin K. Ford, Jing Fan, David I. Israel, Timothy L. Foley, Jinqiao Wan, Ping Xie, Justin Hall, Xu Yanshan
Publikováno v:
Biochemical and biophysical research communications. 527(1)
DNA-encoded libraries (DELs) can contain billions of unique chemical species; selecting against such large inputs, it is typical to find more candidate binders than is reasonable to pursue for follow-up synthesis and testing. Given this wealth of cho
Autor:
Christopher P. Austin, Rajarshi Guha, Madhu Lal-Nag, Bart Trawick, Michelle R. Arkin, Timothy L. Foley, Philip W. Iversen, Jonathan B. Baell, Thomas D.Y. Chung, Zhuyin Li, Eric W. Sayers, Neely Gal-Edd, James McGee, Owen B. McManus, Hanguan Liu, Nathan P. Coussens, Xin Xu, Viswanath Devanaryan, Marilu A. Hoeppner, Matthew D. Hall, Bruce E. Bejcek, Vance Lemmon, Kyle R. Brimacombe, Jeffrey R. Weidner, Jayme L. Dahlin, Andrew D. Napper, Steven D. Kahl, Anton Simeonov, James Inglese, Robert Pacifici, G. Sitta Sittampalam, Lisa Minor, William W. Chin, Abigail Grossman, Julie McVey, Sam Michael, Douglas S. Auld, Stacy Lathrop, Menghang Xia, Terry L. Riss, Mary Jo Wildey, Marcie A. Glicksman, Joseph V. Haas, Stephen C. Kales, O. Joseph Trask
Publikováno v:
Clinical and Translational Science. 11:461-470
The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a "tes
Autor:
Robert Steven Kania, Eric Johnson, Tatlock John H, Luping Qiu, Timothy L. Foley, Shaoxian Sun, Kymberly Levine, Ketan S. Gajiwala, Ciarán N. Cronin, Michelle Kraus, Asako Nagata
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation, migration and evasion. Both kinase-dependent and -independent functions of PTK6 in driving tumor g