Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Timothy L. Denning"'
Publikováno v:
Frontiers in Microbiology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/38563016ee1647aab7b9c47bcae73ad0
Autor:
Hirohito Abo, Aoi Muraki, Akihito Harusato, Tetsuya Imura, Maki Suzuki, Kohta Takahashi, Timothy L. Denning, Hiroto Kawashima
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Intestinal mucins play an essential role in the defense against bacterial invasion and the maintenance of gut microbiota, which is instrumental in the regulation of host immune systems; hence, its dysregulation is a hallmark of metabolic disease and
Externí odkaz:
https://doaj.org/article/1766862cd9df4b9ab9ae3c9abe3501b9
Publikováno v:
ACS Omega, Vol 5, Iss 36, Pp 23118-23128 (2020)
Externí odkaz:
https://doaj.org/article/b67a17b28eca4bc9a041979424534a49
Autor:
Mingcan Yu, Abdul Malik Tyagi, Jau-Yi Li, Jonathan Adams, Timothy L. Denning, M. Neale Weitzmann, Rheinallt M. Jones, Roberto Pacifici
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
T cells are involved in the bone loss induced by parathyroid hormone (PTH), but their origin is unknown. Here, the authors show that the intestinal microbiota is required for PTH to induce bone loss and describes mechanisms for microbiota-mediated gu
Externí odkaz:
https://doaj.org/article/3f73e1cc8c504ed8ad4787bd0c1d7608
Autor:
Hirohito Abo, Benoit Chassaing, Akihito Harusato, Miguel Quiros, Jennifer C. Brazil, Vu L. Ngo, Emilie Viennois, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Gut microbiota and their metabolites regulate homeostasis of the intestine, but their effects on intestine development are unclear. Here the authors use RNAseq and germ free mice to show that intestinal microbiota promote the expression of Erdr1, whi
Externí odkaz:
https://doaj.org/article/041717f946814996be968b7a702f6fb1
Autor:
Hao Q. Tran, Alexis Bretin, Aneseh Adeshirlarijaney, Beng San Yeoh, Matam Vijay-Kumar, Jun Zou, Timothy L. Denning, Benoit Chassaing, Andrew T. Gewirtz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 313-333 (2020)
Background & Aims: Consumption of a low-fiber, high-fat, Western-style diet (WSD) induces adiposity and adipose inflammation characterized by increases in the M1:M2 macrophage ratio and proinflammatory cytokine expression, both of which contribute to
Externí odkaz:
https://doaj.org/article/d5a47e3cffe746f6b56958102173e8d6
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Interleukin (IL)-2 is expressed during T cell activation and induces the proliferation and differentiation of T cells. CD4+Foxp3+ regulatory T cells (Tregs) constitutively express the high affinity IL-2 receptor (CD25/IL-2Rα) and rapidly respond to
Externí odkaz:
https://doaj.org/article/3b419f759c8b433a9e775ee03703b897
Autor:
Aliyah M. Weinstein, Lu Chen, Emily A. Brzana, Prashanti R. Patil, Jennifer L. Taylor, Kellsye L. Fabian, Callen T. Wallace, Sabrina D. Jones, Simon C. Watkins, Binfeng Lu, David F. Stroncek, Timothy L. Denning, Yang-Xin Fu, Peter A. Cohen, Walter J. Storkus
Publikováno v:
OncoImmunology, Vol 6, Iss 6 (2017)
We have previously reported that direct injection of dendritic cells (DC) engineered to express the Type-1 transactivator Tbet (i.e., DC.Tbet) into murine tumors results in antitumor efficacy in association with the development of structures resembli
Externí odkaz:
https://doaj.org/article/ae1cf937d236486eb5995d5b55f30a66
Autor:
Duke Geem, Vu Ngo, Akihito Harusato, Benoit Chassaing, Andrew T. Gewirtz, Rodney D. Newberry, Timothy L. Denning
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 3, Pp 274-280.e3 (2016)
Background & Aims: Foxp3+ regulatory T cells (Tregs) in the intestine promote immune tolerance to enteric antigens. Previous studies have shown that C-C chemokine receptor 7 (CCR7)-dependent migration of intestinal dendritic cells to the mesenteric l
Externí odkaz:
https://doaj.org/article/2e6a911011d142fa95093c81b763b5d8
Autor:
Timothy L. Denning, PhD
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 1, Pp 3-4 (2016)
Externí odkaz:
https://doaj.org/article/2e74aba33a034ca08d5873f5e715940d