Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Timothy L. Bullock"'
Publikováno v:
Biochemistry. 46:8766-8775
S-adenosyl-L-methionine- (AdoMet-) dependent methyltransferases are widespread, play critical roles in diverse biological pathways, and are antibiotic and cancer drug targets. Presently missing from our understanding of any AdoMet-dependent methyl-tr
Publikováno v:
Journal of Biological Chemistry. 280:23978-23986
Glutaminyl-tRNA synthetase generates Gln-tRNA(Gln) 10(7)-fold more efficiently than Glu-tRNA(Gln) and requires tRNA to synthesize the activated aminoacyl adenylate in the first step of the reaction. To examine the role of tRNA in amino acid activatio
Publikováno v:
Journal of Molecular Biology. 328:395-408
The 2.5 A crystal structure of Escherichia coli glutaminyl-tRNA synthetase in a quaternary complex with tRNA(Gln), an ATP analog and glutamate reveals that the non-cognate amino acid adopts a distinct binding mode within the active site cleft. In con
Autor:
Richard S. A. Lipman, Brian S. Sproat, Kate Juliet Newberry, Timothy L. Bullock, Barbro Beijer, Ya-Ming Hou, Luke D. Sherlin, John J. Perona
Publikováno v:
Journal of Molecular Biology. 299:431-446
The position of the tertiary Levitt pair between nucleotides 15 and 48 in the transfer RNA core region suggests a key role in stabilizing the joining of the two helical domains, and in maintaining the relative orientations of the D and variable loops
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(21)
Information transfer from nucleic acid to protein is mediated by aminoacyl-tRNA synthetases, which catalyze the specific pairings of amino acids with transfer RNAs. Despite copious sequence and structural information on the 22 tRNA synthetase familie
Publikováno v:
Nature structural biology. 7(6)
Guided by an in vitro selection experiment designed to obtain tight binding aptamers of Escherichia coli glutamine specific tRNA (tRNAGln) for glutaminyl-tRNA synthetase (GlnRS), we have engineered a tRNA mutant in which the five-nucleotide variable