Výsledky vyhledávání - "Timothy L Mosbruger"

Akademický článek

FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer

Autor: Soledad A Camolotto, Shrivatsav Pattabiraman, Timothy L Mosbruger, Alex Jones, Veronika K Belova, Grace Orstad, Mitchell Streiff, Lydia Salmond, Chris Stubben, Klaus H Kaestner, Eric L Snyder

Publikováno v: eLife, Vol 7 (2018)

Changes in cancer cell identity can alter malignant potential and therapeutic response. Loss of the pulmonary lineage specifier NKX2-1 augments the growth of KRAS-driven lung adenocarcinoma and causes pulmonary to gastric transdifferentiation. Here,

Externí odkaz: https://doaj.org/article/3b7d0675f48d4a07bf22e8d442f8e824

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Akademický článek

Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.

Autor: Somaye Dehghanizadeh, Vahid Khoddami, Timothy L Mosbruger, Sue S Hammoud, Kornelia Edes, Therese S Berry, Michelle Done, Wade S Samowitz, James A DiSario, Daniel G Luba, Randall W Burt, David A Jones

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0192499 (2018)

Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the

Externí odkaz: https://doaj.org/article/578766009c5649dd8f00293743ad0d5b

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Akademický článek

Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth.

Autor: Jared Wallace, Ruozhen Hu, Timothy L Mosbruger, Timothy J Dahlem, W Zac Stephens, Dinesh S Rao, June L Round, Ryan M O'Connell

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0153689 (2016)

Mammalian microRNA expression is dysregulated in human cancer. However, the functional relevance of many microRNAs in the context of tumor biology remains unclear. Using CRISPR-Cas9 technology, we performed a global loss-of-function screen to simulta

Externí odkaz: https://doaj.org/article/a12ce76b539a4da6a0900b63f0d0c5e2

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Akademický článek

A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3’ UTR region, denoting expression levels, are associated with atopic dermatitis

Autor: David J. Margolis, Jamie L. Duke, Nandita Mitra, Ronald A. Berna, Ole J. Hoffstad, Jenna R. Wasserman, Amalia Dinou, Georgios Damianos, Ioanna Kotsopoulou, Nikolaos Tairis, Deborah A. Ferriola, Timothy L. Mosbruger, Tristan J. Hayeck, Albert C. Yan, Dimitri S. Monos

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Introduction: Components of the immune response have previously been associated with the pathophysiology of atopic dermatitis (AD), specifically the Human Leukocyte Antigen (HLA) Class II region via genome-wide association studies, however the exact

Externí odkaz: https://doaj.org/article/daca908e2e89473c9add552149a5579e

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Akademický článek

A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages

Autor: Thomas B. Huffaker, H. Atakan Ekiz, Cindy Barba, Soh-Hyun Lee, Marah C. Runtsch, Morgan C. Nelson, Kaylyn M. Bauer, William W. Tang, Timothy L. Mosbruger, James E. Cox, June L. Round, Warren P. Voth, Ryan M. O’Connell

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state and thereby contributes to their anti-tumour function. Here the authors show an underlying mechanism in this process is IFNy-driven STAT1 occupancy and activation o

Externí odkaz: https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc

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