Výsledky vyhledávání - "Timothy L M Jones"

Akademický článek

The Monocrotaline Rat Model of Right Heart Disease Induced by Pulmonary Artery Hypertension

Autor: Anna Maria Krstic, Timothy L. M. Jones, Amelia S. Power, Marie-Louise Ward

Publikováno v: Biomedicines, Vol 12, Iss 9, p 1944 (2024)

Pulmonary artery hypertension (PAH) is characterised by increased pulmonary vascular resistance (PVR) resulting in elevated pressure in the pulmonary artery supplying the pulmonary circulation. Disease of the right ventricle (RV) often manifests as a

Externí odkaz: https://doaj.org/article/c5dde76abc2e408abdde820a03d673b5

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Akademický článek

Impaired calcium handling mechanisms in atrial trabeculae of diabetic patients

Autor: Timothy L. M. Jones, Sarbjot Kaur, Nicholas Kang, Peter N. Ruygrok, Marie‐Louise Ward

Publikováno v: Physiological Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)

Abstract The aim of this study was to investigate cardiomyocyte Ca2+ handling and contractile function in freshly excised human atrial tissue from diabetic and non‐diabetic patients undergoing routine surgery. Multicellular trabeculae (283 ± 20 μ

Externí odkaz: https://doaj.org/article/6c8f9c4f58b04047a555973ae2b5c992

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Akademický článek

Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment.

Autor: Amelia S Power, Ruth Norman, Timothy L M Jones, Anthony J Hickey, Marie-Louise Ward

Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0214740 (2019)

Pulmonary hypertension (PH) increases the work of the right ventricle (RV) and causes right-sided heart failure. This study examined RV mitochondrial function and ADP transfer in PH animals advancing to right heart failure, and investigated a potenti

Externí odkaz: https://doaj.org/article/2423faa97a574a92b96406869f70202a

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