Výsledky vyhledávání - "Timothy L Hayes"

Akademický článek

HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality.

Publikováno v: PLoS Pathogens, Vol 10, Iss 5, p e1004078 (2014)

A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal

Externí odkaz: https://doaj.org/article/34190c80ee49467aaee778896123b3f0

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Akademický článek

Magnitude and complexity of rectal mucosa HIV-1-specific CD8+ T-cell responses during chronic infection reflect clinical status.

Autor: J William Critchfield, Delandy H Young, Timothy L Hayes, Jerome V Braun, Juan C Garcia, Richard B Pollard, Barbara L Shacklett

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3577 (2008)

The intestinal mucosa displays robust virus replication and pronounced CD4+ T-cell loss during acute human immunodeficiency virus type 1 (HIV-1) infection. The ability of HIV-specific CD8+ T-cells to modulate disease course has prompted intensive stu

Externí odkaz: https://doaj.org/article/77812942c1dd4036814172ca3cad7526

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Accuracy of Point-of-Care Blood Glucose Level Measurements in Critically Ill Patients with Sepsis Receiving High-Dose Intravenous Vitamin C

Autor: Caitlin S. Brown, Timothy L. Hayes, Patricia Lerwick, Richard R. Riker, Teresa May, Kathryn Smith, Bridget M. Manning, Gilles L. Fraser

Publikováno v: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 38:1155-1161

STUDY OBJECTIVE High-dose intravenous vitamin C is a potential treatment option for patients with sepsis and may interfere with point-of-care (POC) blood glucose (BG) testing. This study aimed to determine if vitamin C dosing used for sepsis affected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37962d392b8bd8b021dbf6173f21fbc
https://doi.org/10.1002/phar.2182

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Differential Impact of In Vivo CD8 + T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques

Autor: Thomas H. Vanderford, Benton Lawson, Michael R. Betts, Mirko Paiardini, Timothy L. Hayes, Steven E. Bosinger, Ankita Chowdhury, Jacob D. Estes, Joern E. Schmitz, Guido Silvestri, Ann Chahroudi

Publikováno v: Journal of Virology. 89:8677-8686

Numerous studies have demonstrated that CD8 + T lymphocytes suppress virus replication during human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infection. However, the mechanisms underlying this activity of T cells remain incompl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f935e4d28af5ee8d2ec414dbdba2548
https://doi.org/10.1128/jvi.00869-15

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Low-dose Prothrombin Complex Concentrate for Warfarin-Associated Intracranial Hemorrhage with INR Less Than 2.0

Autor: Timothy L. Hayes, Robert L. Trowbridge, Kathryn Smith, Gene A. Grindlinger, David B. Seder, Teresa May, Wesley R. Zemrak, Stephen S. Rolfe

Publikováno v: Neurocritical care. 27(3)

Prothrombin complex concentrates (PCCs) have become the first-line therapy for warfarin reversal in the setting of central nervous system (CNS) hemorrhage. Randomized, controlled studies comparing agents for warfarin reversal excluded patients with i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76b5b93681f65028fe33e485be89df9
https://pubmed.ncbi.nlm.nih.gov/28660341

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Impact of highly active antiretroviral therapy initiation on CD4+ T-cell repopulation in duodenal and rectal mucosa

Autor: Tammy Yotter, David M. Asmuth, Delandy H. McConnell, Barbara L. Shacklett, Bridget McLaughlin, Timothy L. Hayes, Thomas H. Knight, Juan Carlos Garcia, Richard B. Pollard, J. William Critchfield

Publikováno v: AIDS. 27:867-877

OBJECTIVE The objective of this study was to assess the effects of HAART initiation on CD4(+) T-cell repopulation and T-cell immune activation in rectal and duodenal mucosa. DESIGN The effects of HAART on the gastrointestinal tract remain controversi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c37deb4a1fb009f74817616e5b8ca4
https://doi.org/10.1097/qad.0b013e32835d85b4

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Transcriptional Profiling of Experimental CD8 + Lymphocyte Depletion in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239

Autor: Steven E. Bosinger, Nichole R. Klatt, Timothy L. Hayes, Guido Silvestri, Simon P. Jochems, Kathryn A. Folkner

Publikováno v: Journal of Virology. 87:433-443

CD8 + T cells inhibit virus replication in SIV-infected rhesus macaques. However, it is unclear to what extent the viral suppression mediated by CD8 + T cells reflects direct killing of infected cells as opposed to indirect, noncytolytic mechanisms.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a951f7968675c765088eefe64e1bcf
https://doi.org/10.1128/jvi.01746-12

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Molecular Characterization of Stool Microbiota in HIV-Infected Subjects by Panbacterial and Order-Level 16S Ribosomal DNA (rDNA) Quantification and Correlations With Immune Activation

Autor: Paolo Troia-Cancio, Collin L. Ellis, Heather A. Overman, Richard B. Pollard, Thomas H. Knight, David M. Asmuth, Christopher J. Miller, Chin-Shang Li, Tammy Yotter, Zhong-Min Ma, Jian Wu, John C. Rutledge, Archana Maniar, Surinder K Mann, Anthony Albanese, Natalie J. Török, Timothy L. Hayes

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 57:363-370

Background The relationship between gut microbial community composition at the higher-taxonomic order level and local and systemic immunologic abnormalities in HIV disease may provide insight into how bacterial translocation impacts HIV disease. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b6c30b39504f2c2c24d4ea2caeaa35
https://doi.org/10.1097/qai.0b013e31821a603c

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A Randomized, Controlled Trial of Raltegravir Intensification in Antiretroviral-treated, HIV-infected Patients with a Suboptimal CD4+ T Cell Response

Autor: Rebecca Hoh, Joseph M. McCune, Steven G. Deeks, Peter W. Hunt, Barbara L. Shacklett, Viktor Dahl, Jeffrey N. Martin, Tzong-Hae Lee, Elizabeth Sinclair, Michael P. Busch, Sarah Palmer, Hiroyu Hatano, Harry Lampiris, Timothy L. Hayes

Publikováno v: The Journal of Infectious Diseases. 203:960-968

Highly active antiretroviral therapy (HAART) has been effective in decreasing morbidity and mortality associated with human immunodeficiency virus (HIV) infection [1]. However, a significant proportion of individuals are unable to achieve a normal CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408a9a1a6a85a8d52767abcb6dfc9488
https://doi.org/10.1093/infdis/jiq138

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Measuring Liquid Sulfur Mustard Recovery to Characterize a Weanling Swine Skin Short-Term Exposure Model

Autor: John S. Graham, Timothy L. Hayes, Jonathon W. Kohne, James V. Rogers, Frances M. Reid

Publikováno v: Cutaneous and Ocular Toxicology. 24:177-185

Sulfur mustard [bis(2-chloroethyl)sulfide, SM] is a chemical warfare agent that penetrates the skin and causes extensive blistering. A weanling swine model was previously developed to evaluate woun...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b919d465e196c7ab391b17c57c0f0914
https://doi.org/10.1081/cus-200068610

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