Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Timothy L, Tellinghuisen"'
Publikováno v:
eLife, Vol 7 (2018)
Antiviral development is plagued by drug resistance and genetic barriers to resistance are needed. For HIV and hepatitis C virus (HCV), combination therapy has proved life-saving. The targets of direct-acting antivirals for HCV infection are NS3/4A p
Externí odkaz:
https://doaj.org/article/224a2a5a9e4b4353b3c93e2ea499bc25
Autor:
Susana T. Valente, Avik Biswas, Hyeryun Choe, Cari F. Kessing, F. Toledo, Audrey S. Richard, Sonia Mediouni, A. Barsamian, Joseph A. Jablonski, V. M. Andrade, Y. Even, S. Tsuda, Thomas D. Bannister, Timothy L. Tellinghuisen, Mario Stevenson, Michael D. Cameron
Publikováno v:
J Virol
Oregano essential oil has long been known for its health-promoting benefits. Here, we report its activity against viral replication. Oregano oil was found to specifically inhibit lentiviruses, such as human and simian immunodeficiency viruses (HIV an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea9e14ce7567f3bb5639f6ce8885c7e
https://doi.org/10.1128/jvi.00147-20
https://doi.org/10.1128/jvi.00147-20
Publikováno v:
PLoS Pathogens, Vol 4, Iss 3, p e1000032 (2008)
Hepatitis C virus (HCV) is a significant pathogen, infecting some 170 million people worldwide. Persistent virus infection often leads to cirrhosis and liver cancer. In the infected cell many RNA directed processes must occur to maintain and spread i
Externí odkaz:
https://doaj.org/article/6c5d50b71cc449118a2476d95846b3a0
Autor:
Jessica L. Childs-Disney, Timothy L. Tellinghuisen, Balayeshwanth R. Vummidi, Mark R. Southern, Zi-Fu Wang, Avik Biswas, Gogce Crynen, Matthew D. Disney, Sai Pradeep Velagapudi, Hafeez S. Haniff, Yasumasa Matsumoto, Tuan Tran
Publikováno v:
Chem. 4(10)
Summary Many RNAs cause disease; however, RNA is rarely exploited as a small-molecule drug target. Our programmatic focus is to define privileged RNA motif small-molecule interactions to enable the rational design of compounds that modulate RNA biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce96e47b7556d88f1b4a3c630a28219
https://pubmed.ncbi.nlm.nih.gov/30719503
https://pubmed.ncbi.nlm.nih.gov/30719503
Publikováno v:
Journal of Virology. 90:7205-7218
The hepatitis C virus NS5A protein is tethered to cellular membranes via an amphipathic amino-terminal helix that is inserted in-plane into the outer endoplasmic reticulum (ER)-derived membrane leaflet. The charged face of the helix faces the cytopla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88498891fd05ca201a08b872b26dfaa8
https://doi.org/10.1128/jvi.00037-16
https://doi.org/10.1128/jvi.00037-16
Autor:
M. V. Andrade, Hyeryun Choe, Joseph A. Jablonski, Avik Biswas, Cari F. Kessing, Sonia Mediouni, Audrey S. Richard, Timothy L. Tellinghuisen, Michael D. Cameron, Mario Stevenson, Y. Even, S. Tsuda, Susana T. Valente
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-18 (2018)
There is a constant need to improve antiretrovirals against HIV since therapy is limited by cost, side effects and the emergence of drug resistance. Kudzu is a climbing vine from which the root extract (Pueraria lobata), rich in isoflavones and sapon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601678643b8b0afd854f8f631933f60d
https://doi.org/10.1186/s12977-018-0446-x
https://doi.org/10.1186/s12977-018-0446-x
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Antiviral development is plagued by drug resistance and genetic barriers to resistance are needed. For HIV and hepatitis C virus (HCV), combination therapy has proved life-saving. The targets of direct-acting antivirals for HCV infection are NS3/4A p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c819493f6e77a16790adbcf4d7e5d21d
https://elifesciences.org/articles/32579
https://elifesciences.org/articles/32579
Autor:
Magdalena Piętka-Ottlik, Laura Pedro-Rosa, Suzie Thenin-Houssier, Hyeryun Choe, Louis Scampavia, Felipe Diaz-Griffero, Cindy Buffone, Jakob Fuhrmann, Smitha Kota, Douglas J. Kojetin, Briana Konnick, Blase Billack, Audrey S. Richard, Timothy P. Spicer, Susana T. Valente, Silvana Opp, Ian Mitchelle S. de Vera, Angela Brady, Timothy L. Tellinghuisen
The human immunodeficiency virus type 1 (HIV-1) capsid plays crucial roles in HIV-1 replication and thus represents an excellent drug target. We developed a high-throughput screening method based on a time-resolved fluorescence resonance energy trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88baccd78ba691f5872126376013768f
https://europepmc.org/articles/PMC4808204/
https://europepmc.org/articles/PMC4808204/
Publikováno v:
Drug Discovery Today: Technologies. 9:e195-e204
The hepatitis C virus (HCV) is a significant human pathogen of global impact. Therapeutic intervention to cure infections, although improving with recent specific antivirals, still remains a challenge because of the diversity of HCV genotypes and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c639bc8065ff2ca5f7bebb5cfec7645c
https://doi.org/10.1016/j.ddtec.2011.11.002
https://doi.org/10.1016/j.ddtec.2011.11.002