Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Timothy L, Bosse"'
Autor:
Rita Sulahian, Jason J. Kwon, Katherine H. Walsh, Emma Pailler, Timothy L. Bosse, Maneesha Thaker, Diego Almanza, Joshua M. Dempster, Joshua Pan, Federica Piccioni, Nancy Dumont, Alfredo Gonzalez, Jonathan Rennhack, Behnam Nabet, John A. Bachman, Amy Goodale, Yenarae Lee, Mukta Bagul, Rosy Liao, Adrija Navarro, Tina L. Yuan, Raymond W.S. Ng, Srivatsan Raghavan, Nathanael S. Gray, Aviad Tsherniak, Francisca Vazquez, David E. Root, Ari J. Firestone, Jeff Settleman, William C. Hahn, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 118-134.e8 (2019)
Summary: The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective combination treatment strategy. We performed genome-scale loss-of-function CRISPR-Cas9 scr
Externí odkaz:
https://doaj.org/article/9a62a78ea0ee4966a7135dceb3c889af
Autor:
Brian M. Wolpin, Jonathan A. Nowak, Andrew J. Aguirre, Alex K. Shalek, William C. Hahn, Aram F. Hezel, Albert C. Koong, Daniel T. Chang, Richard F. Dunne, David C. Linehan, Margaret M. Kozak, Emma R. Hill, Lauren K. Brais, Joseph D. Mancias, Jiping Wang, Thomas E. Clancy, James M. Cleary, Kimberly Perez, Harshabad Singh, Douglas A. Rubinson, Vicente Morales-Oyarvide, Dalia Elganainy, Mai Chan Lau, Kristen E. Lowder, Radha L. Kalekar, Timothy L. Bosse, Annan Yang, Junning Wang, Andrew W. Navia, Chen Yuan, Juha P. Väyrynen, Sara A. Väyrynen, Scott P. Ginebaugh, Kevin S. Kapner, Peter S. Winter, Srivatsan Raghavan, Jinming Zhang, Andressa Dias Costa, Hannah L. Williams
Pancreatic ductal adenocarcinoma (PDAC) has been classified into classical and basal-like transcriptional subtypes by bulk RNA measurements. However, recent work has uncovered greater complexity to transcriptional subtypes than was initially apprecia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58901a59881a291461b659642ab759fd
https://doi.org/10.1158/0008-5472.c.6514341.v1
https://doi.org/10.1158/0008-5472.c.6514341.v1
Autor:
Brian M. Wolpin, Jonathan A. Nowak, Andrew J. Aguirre, Alex K. Shalek, William C. Hahn, Aram F. Hezel, Albert C. Koong, Daniel T. Chang, Richard F. Dunne, David C. Linehan, Margaret M. Kozak, Emma R. Hill, Lauren K. Brais, Joseph D. Mancias, Jiping Wang, Thomas E. Clancy, James M. Cleary, Kimberly Perez, Harshabad Singh, Douglas A. Rubinson, Vicente Morales-Oyarvide, Dalia Elganainy, Mai Chan Lau, Kristen E. Lowder, Radha L. Kalekar, Timothy L. Bosse, Annan Yang, Junning Wang, Andrew W. Navia, Chen Yuan, Juha P. Väyrynen, Sara A. Väyrynen, Scott P. Ginebaugh, Kevin S. Kapner, Peter S. Winter, Srivatsan Raghavan, Jinming Zhang, Andressa Dias Costa, Hannah L. Williams
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b8ab2de7cfe7f7ab46e4e9b09fa895
https://doi.org/10.1158/0008-5472.22433331.v1
https://doi.org/10.1158/0008-5472.22433331.v1
Autor:
Hannah L. Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S. Winter, Kevin S. Kapner, Scott P. Ginebaugh, Sara A. Väyrynen, Juha P. Väyrynen, Chen Yuan, Andrew W. Navia, Junning Wang, Annan Yang, Timothy L. Bosse, Radha L. Kalekar, Kristen E. Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A. Rubinson, Harshabad Singh, Kimberly Perez, James M. Cleary, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Lauren K. Brais, Emma R. Hill, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, William C. Hahn, Alex K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M. Wolpin
Publikováno v:
Cancer research.
Pancreatic ductal adenocarcinoma (PDAC) has been classified into classical and basal-like transcriptional subtypes by bulk RNA measurements. However, recent work has uncovered greater complexity to transcriptional subtypes than was initially apprecia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5578179943efe3fd30fd9632eb9d837d
https://pubmed.ncbi.nlm.nih.gov/36459568
https://pubmed.ncbi.nlm.nih.gov/36459568
Autor:
Rosy Liao, Joshua Pan, Raymond W.S. Ng, Federica Piccioni, Jonathan P. Rennhack, Ari J. Firestone, William C. Hahn, Amy Goodale, Diego Almanza, Andrew J. Aguirre, John A. Bachman, Emma Pailler, David E. Root, Srivatsan Raghavan, Tina L. Yuan, Mukta Bagul, Nathanael S. Gray, Alfredo Gonzalez, Yenarae Lee, Jason J. Kwon, Katherine H. Walsh, Nancy Dumont, Timothy L. Bosse, Behnam Nabet, Francisca Vazquez, Jeff Settleman, Aviad Tsherniak, Joshua M. Dempster, Adrija J. Navarro, Maneesha Thaker, Rita Sulahian
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 118-134.e8 (2019)
Summary: The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective combination treatment strategy. We performed genome-scale loss-of-function CRISPR-Cas9 scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01aa685e87c2fe16e8fa52aa6b0efad
http://www.sciencedirect.com/science/article/pii/S2211124719311520
http://www.sciencedirect.com/science/article/pii/S2211124719311520
Publikováno v:
Journal of visualized experiments : JoVE. (138)
This protocol describes a method for measuring the metabolism in Drosophila melanogaster larval and adult brains. Quantifying metabolism in whole organs provides a tissue-level understanding of energy utilization that cannot be captured when analyzin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfc4807376ff8574d5d17a6e5a1b81b3
https://pubmed.ncbi.nlm.nih.gov/30148485
https://pubmed.ncbi.nlm.nih.gov/30148485
Autor:
John F. Mills, James S. Waters, Mia Klekos, Marla Tipping, Steven E. Weicksel, Timothy L. Bosse, Kathryn E. Neville
Background Many neuronal and glial diseases have been associated with changes in metabolism. Therefore, metabolic reprogramming has become an important area of research to better understand disease at the cellular level, as well as to identify target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5430a64dfa286af6a7e218d62ef3dc16
https://europepmc.org/articles/PMC5840572/
https://europepmc.org/articles/PMC5840572/