Výsledky vyhledávání - "Timothy Kogan"

Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity

Autor: Dugar Sundeep, Robert E. Burrier, Brian G. Salisbury, Wayne Vaccaro, Joel G. Berger, Harry R. Davis, Timothy Kogan, John W. Clader, Martin S. Domalski

Publikováno v: Journal of Medicinal Chemistry. 38:1600-1607

Substituted (1,2-diarylethyl)amides have been prepared and evaluated for their ability to inhibit microsomal acyl-CoA:cholesterol acyltransferase activity in vitro and to lower hepatic cholesteryl ester content in vivo in a cholesterol-fed hamster. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d4adcc1028d2f8364af3276d92c19b
https://doi.org/10.1021/jm00010a004

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N-oleoyl-1,2,3,4-tetrahydroisoquinolines as conformationally restricted inhibitors of acyl-CoA:cholesterol acyl transferase (ACAT)

Autor: Robert E. Burrier, Timothy Kogan, Sundeep Dugar, John W. Clader

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:571-576

Oleoyl-amides of variously substituted 1,2,3,4-tetrahydroisoquinolines were synthesized and assayed for their inhibition of acyl-CoA:cholesteral acyl transferase (ACAT) as conformationally restricted analogs of I and II. These were found to be modera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cee88d609f8b07f842802a04aaea8fc
https://doi.org/10.1016/s0960-894x(01)81231-2

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