Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Timothy K. Tippin"'
Publikováno v:
Therapeutic Drug Monitoring
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Background: Brincidofovir (BCV) is an orally bioavailable lipid conjugate of cidofovir (CDV) with increased in vitro potency relative to CDV against all 5 families of double-stranded DNA vir
Background: Brincidofovir (BCV) is an orally bioavailable lipid conjugate of cidofovir (CDV) with increased in vitro potency relative to CDV against all 5 families of double-stranded DNA vir
Autor:
Dhiren R. Thakker, Timothy K. Tippin
Publikováno v:
Journal of Pharmaceutical Sciences. 97:1977-1992
Epithelial cell monolayers are routinely used to evaluate efficacy of paracellular permeability enhancers (PPEs). The purpose of the present work was to investigate how biorelevant refinements to the Caco-2 cell model impact in vitro efficacy (decrea
Autor:
Cosette J. Serabjit-Singh, Victoria E. Thiel-Demby, Joseph W. Polli, Timothy K. Tippin, Joan E. Humphreys
Publikováno v:
Journal of Pharmaceutical Sciences. 93:2567-2572
The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for
Autor:
Jo A. Salisbury, Joan E. Humphreys, Cosette J. Serabjit-Singh, Todd M. Baughman, Timothy K. Tippin, Kelly H. Jordan, Joseph W. Polli, Angela L. Mote
Publikováno v:
Journal of Pharmaceutical Sciences. 92:2082-2089
Recent in vitro studies have suggested that P-glycoprotein (Pgp) and passive membrane permeability may influence the brain concentrations of non-sedating (second-generation) antihistamines. The purpose of this study was to determine the importance of
Autor:
Elizabeth J. Beaudet, Ron Laethem, Steven J. Novick, Zhiyang Zhao, Thomas A. Brodie, Debie J. Hoivik, Andrews Robert Carl, Timothy K. Tippin, Edward L. LeCluyse, J. David Becherer, Jürgen M. Lehmann, Linda B. Moore, Darryl L. McDougald, Summer Jolley, Steven A. Kliewer, Michael D. Gaul, G. Hamilton, Kathy Mellon-Kusibab
Publikováno v:
Drug Metabolism and Disposition. 31:870-877
A series of N-hydroxyformamide tumor necrosis factor-alpha converting enzyme (TACE)/matrix metalloprotease (MMP) inhibitors were evaluated for their potential to induce human cytochrome P450 3A (CYP3A). Two in vitro assays were used: 1) a cell-based
Autor:
Thomas A. Kost, J. Darren Stuart, Deborah Simpson Noel, Laurie K. Overton, Sue H. Kadwell, Timothy K. Tippin, H. Neal Bramson, Kenneth Batchelor, Russell L. Yeager, Christine R. Hoffman, Frank Lee
Publikováno v:
Biochemical Pharmacology. 62:933-942
The interaction of baculovirus expressed rat steroid 5alpha-reductase types 1 and 2 (r5AR1 and r5AR2) with 17beta-N-(2,5-bis(trifluoromethyl)phenyl)carbamoyl-4-aza-5alpha-androst-1-en-3-one (GI198745) was investigated at pH 7 and 37 degrees. This 5al
Autor:
H. N. Bramson, Kenneth Batchelor, J. E. Long, Roger N. Hiner, Frank Lee, Marcia L. Moss, R. A. Jun. Mook, J. D. Stuart, J. Van Arnold, Stephen V. Frye, Stephanie L. Schweiker, Mary K. Grizzle, Curt D. Haffner, Michael K. James, Timothy K. Tippin, G. Tian, Patrick R. Maloney, S V Schuster, D. M. Bickett, Rayomand J. Unwalla, G. F. Jun. Dorsey
Publikováno v:
ChemInform. 25
Autor:
Timothy K. Tippin, Mary Jo Numerick, Tammy M. Stone, Karl Whitney, Joan G. Wilson, Jon L. Collins, William G. Benson, Michael A. Watson, Steven A. Kliewer, Deborah A. Winegar
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 16(6)
The nuclear oxysterol receptors liver X receptor-α [LXRα (NR1H3)] and LXRβ (NR1H2) coordinately regulate genes involved in cholesterol homeostasis. Although both LXR subtypes are expressed in the brain, their roles in this tissue remain largely un
Autor:
Marcia L. Moss, David J. Cowan, Bubacz Dulce Garrido, Timothy K. Tippin, Stanford Jennifer Badiang, Michele C. Rizzolio, Robert W. Wiethe, Darryl Lynn Mcdougald, Lee T. Schaller, Joseph H. Chan, James G. Conway, Millard H. Lambert, Justin L. Mitchell, Robert Carl Andrews, M. Anthony Leesnitzer, David Lee Musso, Janet Warner, Andersen Marc W, Michael H. Rabinowitz, J. David Becherer, Kimberly C. Glennon, D. Mark Bickett, Michael D. Gaul, L.Graham Whitesell, Elizabeth J. Beaudet, Richard Austin, Kevin M. Hedeen
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(16)
N -Hydroxyformamide-class metalloprotease inhibitors were designed and synthesized, which have potent broad-spectrum activity versus matrix metalloproteases and TNF-α converting enzyme (TACE). Compound 13c possesses good oral and intravenous pharmac
Autor:
James E. Long, J. Darren Stuart, Timothy K. Tippin, Marcia L. Moss, Dallas K. Croom, Michael K. James, Stephen V. Frye, Frank W. Lee, D. Mark Bickett, Kenneth William Batchelor, Curt Dale Haffner, John Van Arnold, George F. Dorsey, Patrick R. Maloney, Rayomand J. Unwalla, Stephanie L. Schweiker, Roger N. Hiner, H. Neal Bramson, Gaochoa Tian, Mary K. Grizzle, Robert A. Noe
Publikováno v:
Journal of medicinal chemistry. 38(14)
A variety of C17 amide-substituted 6-azaandrost-4-en-3-ones were prepared and tested versus human type 1 and 2 steroid 5 alpha-reductase (5AR) and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase (3BHSD) in