Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Timothy K. Goggin"'
Autor:
Hagop M. Kantarjian, Xiang Yao Su, Mohammad Azab, James N. Lowder, Cong Xu, Pietro Taverna, Timothy K. Goggin, Aram Oganesian
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 6:712-718
Guadecitabine (SGI-110) is a novel next-generation hypomethylating agent (HMA) administered as s.c. injection with extended decitabine exposure. Dose/exposure-response analyses of longitudinal measures of long interspersed nucleotide element-1 (LINE-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc16ecb5eabaed09767feb7421d1827a
https://doi.org/10.1002/psp4.12248
https://doi.org/10.1002/psp4.12248
Autor:
Annamaria Jakab, Timothy K. Goggin, Cornelia Quadt, Markus Boehm, Stefan De Buck, Dejan Juric, Douglas Bootle
Publikováno v:
British Journal of Clinical Pharmacology. 78:543-555
Aims The aim was to characterize the population pharmacokinetics of BYL719 in cancer patients and assess the time course of tumour response in relation to drug exposure and dosing schedule. Methods Plasma samples and longitudinal tumour size measurem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5695a0e4295430267de3e301d0c07fac
https://doi.org/10.1111/bcp.12378
https://doi.org/10.1111/bcp.12378
Autor:
Thorunn Helgason, Douglas Bootle, David Demanse, Cornelia Quadt, Ana M. Gonzalez-Angulo, Guillem Argiles, Markus Boehm, Timothy K. Goggin, Martin Schuler, Robin M.J.M. van Geel, Howard A. Burris, Jordan Berlin, José Baselga, Jan H.M. Schellens, Dejan Juric, Mark R. Middleton
2531 Background: BYL719 is an oral small-molecule inhibitor of the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K), which is encoded by the PIK3CA gene, one of the most commonly mutated genes in human cancers. BYL719 inhibits prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f376c02364f15373beb5a727de75f5b9
