Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Timothy Johanssen"'
Autor:
Daniel Ebner, Olaf Ansorge, Hena Khalique, Richard Baugh, Janet Lei-Rossmann, Emma Page, Peter Kok-Ting Wan, Leonard W Seymour, Timothy Johanssen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Glioblastoma (GBM) almost invariably becomes resistant towards conventional treatment of radiotherapy and temozolomide (TMZ) chemotherapy, partly due to subpopulations of intrinsically resistant glioma stem-like cells (GSC). The oncolytic
Externí odkaz:
https://doaj.org/article/c51c561733e644468744f3bff707e850
Autor:
Paschalis Athanasiadis, Balaguru Ravikumar, Richard J.R. Elliott, John C. Dawson, Neil O. Carragher, Paul A. Clemons, Timothy Johanssen, Daniel Ebner, Tero Aittokallio
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107209- (2023)
Summary: Designing a targeted screening library of bioactive small molecules is a challenging task since most compounds modulate their effects through multiple protein targets with varying degrees of potency and selectivity. We implemented analytic p
Externí odkaz:
https://doaj.org/article/1cefd29b3ccb49cbab7215e3ecc6518e
Autor:
Timothy Johanssen, Laura McVeigh, Sara Erridge, Geoffrey Higgins, Joelle Straehla, Margaret Frame, Tero Aittokallio, Neil O. Carragher, Daniel Ebner
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Glioblastoma (GBM) remains a cancer of high unmet clinical need. Current standard of care for GBM, consisting of maximal surgical resection, followed by ionisation radiation (IR) plus concomitant and adjuvant temozolomide (TMZ), provides less than 15
Externí odkaz:
https://doaj.org/article/6cf6e85854b04711b730a64dda9229c5
Autor:
Timothy Johanssen, Nuttawat Suphantarida, Paul S. Donnelly, Xiang M. Liu, Steven Petrou, Andrew F. Hill, Kevin J. Barnham
Publikováno v:
Neurobiology of Disease, Vol 81, Iss , Pp 176-185 (2015)
Excitotoxicity is the pathological process by which neuronal death occurs as a result of excessive stimulation of receptors at the excitatory synapse such as the NMDA receptor (NMDAR). Excitotoxicity has been implicated in the acute neurological dama
Externí odkaz:
https://doaj.org/article/bfb7b9cc0f394ff288d9e4f394def17d
Autor:
Timothy Johanssen, Daniel Ebner, Balaguru Ravikumar, Paschalis Athanasiadis, Tero Aittokallio, Paul A. Clemons, Neil O. Carragher
Designing a focused compound screening library of bioactive small molecules is a challenging task since many compounds modulate their effects through multiple protein targets with various degrees of potency and selectivity. We describe here several a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748c8dfc9e6fb52c123403da6481c113
https://doi.org/10.1101/2020.11.30.403329
https://doi.org/10.1101/2020.11.30.403329
Autor:
Timothy Johanssen, James C. Griffith, Bruce X. Wong, James A. Duce, Adam P Gunn, Robert A. Cherny, Kevin J. Barnham, Ashley I. Bush, Colin L. Masters
Publikováno v:
Journal of Biological Chemistry. 291:6134-6145
Pyroglutamate-modified amyloid-β (pE-Aβ) is a highly neurotoxic amyloid-β (Aβ) isoform and is enriched in the brains of individuals with Alzheimer disease compared with healthy aged controls. Pyroglutamate formation increases the rate of Aβ olig
Autor:
Colin L. Masters, Steven J. Collins, Timothy Johanssen, Vanessa A Johanssen, Andrew F. Hill, Kevin J. Barnham
Publikováno v:
Biochemical Journal. 459:103-115
Misfolding of PrPC (cellular prion protein) to β-strand-rich conformations constitutes a key event in prion disease pathogenesis. PrPC can undergo either of two constitutive endoproteolytic events known as α- and β-cleavage, yielding C-terminal fr
Autor:
Lin Wai Hung, Keyla Perez, Nicki A. Sherrat, Colin L. Masters, Victor L. Villemagne, Andrew D Watt, Alan Rembach, Timothy Johanssen, Kevin J. Barnham, Craig A. Hutton, Michelle T. Fodero-Tavoletti, Catriona McLean, Woan Mei Kok
Publikováno v:
Acta Neuropathologica. 125:549-564
The formation of low-order oligomers of β-amyloid (Aβ) within the brain is widely believed to be a central component of Alzheimer's disease (AD) pathogenesis. However, despite advances in high-throughput and high-resolution techniques such as xMAP
Autor:
Tong-Lay Lau, John D. Wade, Timothy Johanssen, Cyril C. Curtain, Varsha Lal, Kevin J. Barnham, Jeffrey P. Smith, Roberto Cappai, Giuseppe D. Ciccotosto, Colin L. Masters, Deborah J. Tew, Danielle G. Smith, Keyla Perez, Frances Separovic, Simon C. Drew
Publikováno v:
Neurobiology of Aging. 32:235-248
Previous studies suggest membrane binding is a key determinant of amyloid β (Aβ) neurotoxicity. However, it is unclear whether this interaction is receptor driven. To address this issue, a D-handed enantiomer of Aβ42 (D-Aβ42) was synthesized and
Autor:
Ashley I. Bush, Robert A. Cherny, Timothy Johanssen, Giuseppe D. Ciccotosto, Jeffrey P. Smith, Anthony R. White, Colin L. Masters, Deborah J. Tew, Greg A. Cranston, Irene Volitakis, Vijaya Kenche, Xiang Liu, David Smith, Roberto Cappai, Kevin J. Barnham, Keyla Perez
Publikováno v:
Proceedings of the National Academy of Sciences. 105:6813-6818
Amelyoid-β peptide (Aβ) is a major causative agent responsible for Alzheimer's disease (AD). Aβ contains a high affinity metal binding site that modulates peptide aggregation and toxicity. Therefore, identifying molecules targeting this site repre