Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Timothy J. Wendorff"'
Autor:
Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu
Publikováno v:
Nature, vol 609, iss 7926
The RAS–RAF pathway is one of the most commonly dysregulated in human cancers1–3. Despite decades of study, understanding of the molecular mechanisms underlying dimerization and activation4 of the kinase RAF remains limited. Recent structures of
Autor:
Timothy J Wendorff, James M Berger
Publikováno v:
eLife, Vol 7 (2018)
Type II topoisomerases manage DNA supercoiling and aid chromosome segregation using a complex, ATP-dependent duplex strand passage mechanism. Type IIB topoisomerases and their homologs support both archaeal/plant viability and meiotic recombination.
Externí odkaz:
https://doaj.org/article/f692e0d3cc59404f972113f45c7c40a1
Publikováno v:
Molecular Cancer Research. 21:A036-A036
The RAS-RAF-MEK-ERK signaling axis is upregulated in many human cancers due to its central role in cell growth, differentiation and survival. Oncogenic transformation frequently arises from RAS, BRAF and MEK mutations that activate the pathway. In th
Autor:
Stephen Schmidt, Steve Sideris, Emily J. Hanan, Eric Torres, Jawahar Sudhamsu, Kyung Song, Lan K. Nguyen, Kyle A. Edgar, Nicholas F. Endres, Timothy J. Wendorff, Georgia Hatzivassiliou, Akash Das, Noriko Ishisoko, Lori Friedman, Victorai Schutz, Matt Saabye, Steven T. Staben, Hans E. Purkey, Divya Murali
Publikováno v:
Molecular Cancer Research. 18:PR03-PR03
Activating mutations in PIK3CA are among the most significant oncogenic events across all cancers, making it an important target for drug development. Yet the application of PI3K inhibitors in the clinic has been limited by the difficulty of achievin
Autor:
James M. Berger, Timothy J. Wendorff
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Type II topoisomerases manage DNA supercoiling and aid chromosome segregation using a complex, ATP-dependent duplex strand passage mechanism. Type IIB topoisomerases and their homologs support both archaeal/plant viability and meiotic recombination.
Publikováno v:
Biophysical Journal. 102(9):2022-2030
Vinculin phosphorylation has been implicated as a potential mechanism for focal adhesion growth and maturation. Four vinculin residues—Y100, S1033, S1045, and Y1065—are phosphorylated by kinases during focal adhesion maturation. In this study, ph
Autor:
Ruth M. Saecker, Jonathan G. Cannon, Megan Kratz, Laurel M. Pegram, Timothy J. Wendorff, Demian Riccardi, Michael W. Capp, M. Thomas Record
Publikováno v:
Biochemistry. 48:10372-10379
Noncovalent self-assembly of biopolymers is driven by molecular interactions between functional groups on complementary biopolymer surfaces, replacing interactions with water. Since individually these interactions are comparable in strength to intera
Publikováno v:
Macromolecular Chemistry and Physics. 210:1201-1209
Two hybrid polymers, poly(methylsilsesquioxane)-poly(2,2-diethoxyethyl acrylate) and poly-(methylsilsesquioxane)-poly(1,3-dioxolan-2-ylmethyl acrylate), were synthesized and used for preparation of stable surface coatings. Their acetal side groups co
Publikováno v:
Journal of Molecular Biology. (3-4):109-124
Type II topoisomerases are required for the management of DNA superhelicity and chromosome segregation, and serve as frontline targets for a variety of small-molecule therapeutics. To better understand how these enzymes act in both contexts, we deter