Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Timothy J. W. Dawes"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2020)
Cardiovascular conditions remain the leading cause of mortality and morbidity worldwide, with genotype being a significant influence on disease risk. Cardiac imaging-genetics aims to identify and characterize the genetic variants that influence funct
Externí odkaz:
https://doaj.org/article/c1e7d9a6a8324a7aa9fdaf4ae5e93691
Autor:
Timothy J. W. Dawes, Colm McCabe, Konstantinos Dimopoulos, Iain Stewart, Simon Bax, Carl Harries, Chinthaka B. Samaranayake, Aleksander Kempny, Philip L. Molyneaux, Samuel Seitler, Thomas Semple, Wei Li, Peter M. George, Vasileios Kouranos, Felix Chua, Elisabetta A. Renzoni, Maria Kokosi, Gisli Jenkins, Athol U. Wells, Stephen J. Wort, Laura C. Price
Publikováno v:
Respirology. 28:262-272
Background and Objective Pulmonary hypertension is a life-limiting complication of interstitial lung disease (ILD-PH). We investigated whether treatment with phosphodiesterase 5 inhibitors (PDE5i) in patients with ILD-PH was associated with improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873f3696df264d6cae2ff5802e3ca085
https://doi.org/10.1111/resp.14378
https://doi.org/10.1111/resp.14378
Autor:
Lan Zhao, Li Huang, Christopher J. Rhodes, Luke Howard, Zhihui Zhao, Chang-Ming Xiong, Karen Sheares, Robin Condliffe, Manuel J. Richter, Joanna Pepke-Zaba, David G. Kiely, Qin Luo, Antonio de Marvao, Zhihong Liu, Anna Ulrich, Xiao-li Jing, John Wharton, Peter A. Robbins, Jian-Guo He, Nicholas W. Morrell, Martin R. Wilkins, Chenhong An, Hossein A. Ghofrani, Henning Gall, Geoffrey Watson, Ruilin Quan, Les Huson, Timothy J W Dawes
Publikováno v:
Annals of the American Thoracic Society
Rationale: Iron deficiency, in the absence of anemia, is common in patients with idiopathic and heritable pulmonary arterial hypertension (PAH) and is associated with a worse clinical outcome. Oral iron absorption may be impeded by elevated circulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07d6b81ef90372e834f666f81961aaf
https://doi.org/10.1513/annalsats.202009-1131oc
https://doi.org/10.1513/annalsats.202009-1131oc
Autor:
Carlo Biffi, Marina Quinlan, Antonio de Marvao, Declan P. O'Regan, Francesco Mazzarotto, Antonis Pantazis, Daniel Rueckert, Marjola Thanaj, James S. Ware, Paul J.R. Barton, Kathryn A. McGurk, Brian P Halliday, Pawel Tokarczuk, Nicola Whiffin, Roddy Walsh, Mikyung Jang, Timothy J W Dawes, Jinming Duan, Catherine Francis, A. John Baksi, Carolyn Y. Ho, Upasana Tayal, Sanjay K Prasad, Ben Statton, Sean L. Zheng, Stuart A. Cook, Pantazis I. Theotokis, Xiao Xu, Nicoló Savioli, Alaine Berry, Wenjia Bai, Rachel Buchan, Xiaolei Zhang
Publikováno v:
Journal of the American College of Cardiology, 78(11), 1097-1110. Elsevier USA
Background: Hypertrophic cardiomyopathy (HCM) is caused by rare variants in sarcomere-encoding genes, but little is known about the clinical significance of these variants in the general population. Objectives: The goal of this study was to compare l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fa696cfb6bb9d920e8de49f63da308
https://pure.amc.nl/en/publications/phenotypic-expression-and-outcomes-in-individuals-with-rare-genetic-variants-of-hypertrophic-cardiomyopathy(6af7fbb2-87d0-4612-938b-7c885feffbaa).html
https://pure.amc.nl/en/publications/phenotypic-expression-and-outcomes-in-individuals-with-rare-genetic-variants-of-hypertrophic-cardiomyopathy(6af7fbb2-87d0-4612-938b-7c885feffbaa).html
Autor:
de Marvao A, Daniel Rueckert, Alaine Berry, Nicoló Savioli, Carlo Biffi, Declan P. O'Regan, Marina Quinlan, Roddy Walsh, Carolyn Y. Ho, S Prasad, Jang M, Francesco Mazzarotto, Nicola Whiffin, Upasana Tayal, Pantazis I. Theotokis, Pawel Tokarczuk, Kathryn A. McGurk, S A Cook, Timothy J W Dawes, James S. Ware, Brian P Halliday, Antonis Pantazis, Benjamin Statton, Marjola Thanaj, Jinming Duan, Catherine Francis, Sean L. Zheng, Paul J.R. Barton, Xiaolei Zhang, Wenjia Bai, Baksi Aj, Xiao Xu, Rachel Buchan
BackgroundHypertrophic cardiomyopathy (HCM) is caused by rare variants in sarcomere-encoding genes, but little is known about the clinical significance of these variants in the general population.MethodsWe compared outcomes and cardiovascular phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064f3713df70e3f14349cc12aee36232
https://doi.org/10.1101/2021.01.21.21249470
https://doi.org/10.1101/2021.01.21.21249470
Autor:
Daniel Rueckert, Paul M. Matthews, James S. Ware, Ewan Birney, Wenjia Bai, Albert Henry, Sanjay K Prasad, Jakob Gierten, Thomas Thumberger, Maria Laura Costantino, Stuart A. Cook, Marta Serrani, Pawel Tokarczuk, Declan P. O'Regan, Hannah Meyer, Joachim Wittbrodt, Timothy J W Dawes, Antonio de Marvao, R. Thomas Lumbers, Jiashen Cai
Publikováno v:
Nature
The inner surfaces of the human heart are covered by a complex network of muscular strands that is thought to be a remnant of embryonic development1,2. The function of these trabeculae in adults and their genetic architecture are unknown. Here we per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22237bfba89a5d81fa41f7fe5e28a8cd
http://hdl.handle.net/10044/1/80636
http://hdl.handle.net/10044/1/80636
Autor:
K Thomson, Pantazis I. Theotokis, Antonio de Marvao, Mian Ahmad, Risha Govind, Alicja Wilk, Sanjay K Prasad, Nicola Whiffin, Alexander Ing, Stuart A. Cook, Francesco Mazzarotto, David Sim, A. John Baksi, Upasana Tayal, Elizabeth Edwards, Leanne E. Felkin, Angharad M. Roberts, Iacopo Olivotto, Declan P. O'Regan, Antonis Pantazis, Rachel Buchan, James S. Ware, Laura Lihua Chan, Roddy Walsh, William Midwinter, Timothy J W Dawes, Erica Mazaika, Paul J.R. Barton, Hugh Watkins, Birgit Funke
Publikováno v:
Circulation
Circulation, 141(5), 387-398. Lippincott Williams and Wilkins
Circulation, 141(5), 387-398. Lippincott Williams and Wilkins
Supplemental Digital Content is available in the text.
Background: Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100 purported disease genes tested in clinical laboratories. However, many genes were originally identified based
Background: Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100 purported disease genes tested in clinical laboratories. However, many genes were originally identified based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6d5f50cc6112a9c66a70ac46ac1400
http://hdl.handle.net/11379/545740
http://hdl.handle.net/11379/545740
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2020)
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine
Cardiovascular conditions remain the leading cause of mortality and morbidity worldwide, with genotype being a significant influence on disease risk. Cardiac imaging-genetics aims to identify and characterize the genetic variants that influence funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71adb2e561fc704ea6e621bd8df645bb
https://www.frontiersin.org/article/10.3389/fcvm.2019.00195/full
https://www.frontiersin.org/article/10.3389/fcvm.2019.00195/full
Autor:
Tristan Fletcher, Daniel Rueckert, Antonio de Marvao, John Wharton, Christopher J. Rhodes, Stuart A. Cook, Declan P. O'Regan, Geoffrey Watson, Timothy J W Dawes, Wenzhe Shi, Martin R. Wilkins, Luke Howard, J. Simon R. Gibbs
Publikováno v:
Radiology
Applying machine learning of complex motion phenotypes obtained from cardiac MR images allows more accurate prediction of patient outcomes in pulmonary hypertension.
Purpose To determine if patient survival and mechanisms of right ventricular fa
Purpose To determine if patient survival and mechanisms of right ventricular fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac894acdffe79e4bc70cc2b7831d9b7b
https://doi.org/10.1148/radiol.2016161315
https://doi.org/10.1148/radiol.2016161315
Autor:
Hannah Meyer, Pawel Tokarczuk, Jiashen Cai, Daniel Rueckert, Declan P. O'Regan, Paul M. Matthews, Timothy J W Dawes, Wenjia Bai, Ewan Birney, Stuart A. Cook, Antonio de Marvao, Maria Laura Costantino, Marta Serrani
Since being first described by Leonardo da Vinci in 1513 it has remained an enigma why the endocardial surfaces of the adult heart retain a complex network of muscular trabeculae – with their persistence thought to be a vestige of embryonic develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c2c866fa7a47292f99b0d1d8f9eb2e