Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Timothy J. Stuhlmiller"'
Autor:
Chialin Cheng, Surya A. Reis, Emily T. Adams, Daniel M. Fass, Steven P. Angus, Timothy J. Stuhlmiller, Jared Richardson, Hailey Olafson, Eric T. Wang, Debasis Patnaik, Roberta L. Beauchamp, Danielle A. Feldman, M. Catarina Silva, Mriganka Sur, Gary L. Johnson, Vijaya Ramesh, Bruce L. Miller, Sally Temple, Kenneth S. Kosik, Bradford C. Dickerson, Stephen J. Haggarty
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation levels and accumulation of misfolded tau protein that can propagate between neurons u
Externí odkaz:
https://doaj.org/article/dbd7b9c359124c2ab41cec4cd38e2e30
Autor:
Steven P. Angus, Timothy J. Stuhlmiller, Gaurav Mehta, Samantha M. Bevill, Daniel R. Goulet, J. Felix Olivares-Quintero, Michael P. East, Maki Tanioka, Jon S. Zawistowski, Darshan Singh, Noah Sciaky, Xin Chen, Xiaping He, Naim U. Rashid, Lynn Chollet-Hinton, Cheng Fan, Matthew G. Soloway, Patricia A. Spears, Stuart Jefferys, Joel S. Parker, Kristalyn K. Gallagher, Andres Forero-Torres, Ian E. Krop, Alastair M. Thompson, Rashmi Murthy, Michael L. Gatza, Charles M. Perou, H. Shelton Earp, Lisa A. Carey, Gary L. Johnson
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Inhibition of the HER2/ERBB2 receptor is a keystone to treating HER2-positive malignancies, particularly breast cancer, but a significant fraction of HER2-positive (HER2+) breast cancers recur or fail to respond. Anti-HER2 monoclonal antibod
Externí odkaz:
https://doaj.org/article/c11b8d70dbc348e48996b9c35fbb436b
Autor:
Timothy J. Stuhlmiller, Samantha M. Miller, Jon S. Zawistowski, Kazuhiro Nakamura, Adriana S. Beltran, James S. Duncan, Steven P. Angus, Kyla A.L. Collins, Deborah A. Granger, Rachel A. Reuther, Lee M. Graves, Shawn M. Gomez, Pei-Fen Kuan, Joel S. Parker, Xin Chen, Noah Sciaky, Lisa A. Carey, H. Shelton Earp, Jian Jin, Gary L. Johnson
Publikováno v:
Cell Reports, Vol 11, Iss 3, Pp 390-404 (2015)
Therapeutics that target ERBB2, such as lapatinib, often provide initial clinical benefit, but resistance frequently develops. Adaptive responses leading to lapatinib resistance involve reprogramming of the kinome through reactivation of ERBB2/ERBB3
Externí odkaz:
https://doaj.org/article/ed7a28c1915c491791b6cd80ddc9e842
Autor:
Timothy J. Stuhlmiller, Jon S. Zawistowski, Xin Chen, Noah Sciaky, Steven P. Angus, Sean T. Hicks, Traci L. Parry, Wei Huang, Ju Youn Beak, Monte S. Willis, Gary L. Johnson, Brian C. Jensen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 10 (2017)
BackgroundMost novel cancer therapeutics target kinases that are essential to tumor survival. Some of these kinase inhibitors are associated with cardiotoxicity, whereas others appear to be cardiosafe. The basis for this distinction is unclear, as ar
Externí odkaz:
https://doaj.org/article/d36f8601e46a4d959fdf94cd5321fe07
Autor:
Gary L. Johnson, Jon S. Zawistowski, Steven P. Angus, Charlene M. Santos, Nathaniel J. Moorman, Andrew Hale, Timothy J. Stuhlmiller, Naim U. Rashid, Adriana S. Beltran, Darshan Singh, Brian T. Golitz, Noah Sciaky, Jose F. Olivares-Quintero, Samantha M. Bevill
File includes drug synergy scores for 1 cell line screened against OTX015
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a25e1d1b980bfd39e3876778cdebb5
https://doi.org/10.1158/1541-7786.22513420.v1
https://doi.org/10.1158/1541-7786.22513420.v1
Autor:
Gary L. Johnson, Jon S. Zawistowski, Steven P. Angus, Charlene M. Santos, Nathaniel J. Moorman, Andrew Hale, Timothy J. Stuhlmiller, Naim U. Rashid, Adriana S. Beltran, Darshan Singh, Brian T. Golitz, Noah Sciaky, Jose F. Olivares-Quintero, Samantha M. Bevill
File contains information on small molecules included in screening library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e500f09a798f7186892bf9a32f9e558f
https://doi.org/10.1158/1541-7786.22513426.v1
https://doi.org/10.1158/1541-7786.22513426.v1
Autor:
Gary L. Johnson, Jon S. Zawistowski, Steven P. Angus, Charlene M. Santos, Nathaniel J. Moorman, Andrew Hale, Timothy J. Stuhlmiller, Naim U. Rashid, Adriana S. Beltran, Darshan Singh, Brian T. Golitz, Noah Sciaky, Jose F. Olivares-Quintero, Samantha M. Bevill
File includes AlphaScreening values for activity of the screening library against the BET or p300 bromodomains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca58033c88ff333e059b8d6933e936f7
https://doi.org/10.1158/1541-7786.22513414.v1
https://doi.org/10.1158/1541-7786.22513414.v1
Autor:
Gary L. Johnson, Jon S. Zawistowski, Steven P. Angus, Charlene M. Santos, Nathaniel J. Moorman, Andrew Hale, Timothy J. Stuhlmiller, Naim U. Rashid, Adriana S. Beltran, Darshan Singh, Brian T. Golitz, Noah Sciaky, Jose F. Olivares-Quintero, Samantha M. Bevill
Supplemental figures, figure legends, table legends, methods, and references
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9495352fd55781725b403c0c9eaa25e9
https://doi.org/10.1158/1541-7786.22513408
https://doi.org/10.1158/1541-7786.22513408
Autor:
Gary L. Johnson, Jon S. Zawistowski, Steven P. Angus, Charlene M. Santos, Nathaniel J. Moorman, Andrew Hale, Timothy J. Stuhlmiller, Naim U. Rashid, Adriana S. Beltran, Darshan Singh, Brian T. Golitz, Noah Sciaky, Jose F. Olivares-Quintero, Samantha M. Bevill
File includes drug synergy scores for 4 cell lines screened against CPI-637
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32787b75ebaf23a8ecf97572e9e075e5
https://doi.org/10.1158/1541-7786.22513417
https://doi.org/10.1158/1541-7786.22513417
Autor:
Gary L. Johnson, Jon S. Zawistowski, Steven P. Angus, Charlene M. Santos, Nathaniel J. Moorman, Andrew Hale, Timothy J. Stuhlmiller, Naim U. Rashid, Adriana S. Beltran, Darshan Singh, Brian T. Golitz, Noah Sciaky, Jose F. Olivares-Quintero, Samantha M. Bevill
File includes drug synergy scores for 6 cell lines screened against JQ1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ccea60d55a1050e17e71d5be43fd0f
https://doi.org/10.1158/1541-7786.22513423
https://doi.org/10.1158/1541-7786.22513423