Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Timothy J. Senter"'
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A general, enantioselective synthesis of N-alkyl terminal aziridines and C2-functionalized azetidines via organocatalysis
Autor: Matthew C. O’Reilly, Craig W. Lindsley, Gary A. Sulikowski, Timothy J. Senter, Katherine M. Chong
Publikováno v: Tetrahedron Letters. 56:1276-1279
A short, high-yielding protocol involving the enantioselective α-chlorination of aldehydes has been developed for the enantioselective synthesis of C2-functionalized aziridines and N-alkyl terminal azetidines from a common intermediate. This methodo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27f6bc63a2f9b889c685b743482b8481
https://doi.org/10.1016/j.tetlet.2015.01.140
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3
High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction
Autor: Trupta Purohit, Shaun R. Stauffer, Rocco D. Gogliotti, Changho Han, Jonathan Pollock, Craig W. Lindsley, Sunil K. Upadhyay, Jolanta Grembecka, Tomasz Cierpicki, Timothy J. Senter, Shihan He
Publikováno v: Journal of Medicinal Chemistry
The protein–protein interaction (PPI) between menin and mixed lineage leukemia (MLL) plays a critical role in acute leukemias, and inhibition of this interaction represents a new potential therapeutic strategy for MLL leukemias. We report developme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0500dd16a4aa46591f6b69f50349f688
https://doi.org/10.1021/jm401868d
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4
A general, enantioselective synthesis of 1-azabicyclo[m.n.0]alkane ring systems
Autor: Tyler E. Wadzinski, Timothy J. Senter, Leah C. Konkol, Michael L. Schulte, Craig W. Lindsley
Publikováno v: Tetrahedron Letters. 54:1645-1648
In this Letter, we describe a novel approach for the general and enantioselective synthesis of a diverse array of small to large 1-azabicyclo[m.n.0]alkyl ring systems with an embedded olefin handle for further functionalization. The stereochemistry i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57e861802911ad6a80edf6310b80c455
https://doi.org/10.1016/j.tetlet.2013.01.041
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5
Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz-Schiemann Reaction
Autor: Nathaniel H. Park, Stephen L. Buchwald, Timothy J. Senter
Publikováno v: Angewandte Chemie (International ed. in English). 55(39)
The Balz–Schiemann reaction remains a highly utilized means for preparing aryl fluorides from anilines. However, the limitations associated with handling aryl diazonium salts often hinder both the substrate scope and scalability of this reaction. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11375abc8ca6f625447bb591794e0649
https://pubmed.ncbi.nlm.nih.gov/27558308
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6
A general, enantioselective synthesis of
Autor: Timothy J, Senter, Matthew C, O'Reilly, Katherine M, Chong, Gary A, Sulikowski, Craig W, Lindsley
Publikováno v: Tetrahedron letters
A short, high-yielding protocol involving the enantioselective α-chlorination of aldehydes has been developed for the enantioselective synthesis of C2-functionalized aziridines and N-alkyl terminal azetidines from a common intermediate. This methodo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f5c0466b79ca404ff826bec23587b1b
https://pubmed.ncbi.nlm.nih.gov/26834294
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7
A Versatile Enantioselective Synthesis of Azabicyclic Ring Systems: A Concise Total Synthesis of (+)-Grandisine D and Unnatural Analogues
Autor: Timothy J. Senter, Craig W. Lindsley, Olugbeminiyi O. Fadeyi, Kristopher N. Hahn
Publikováno v: Chemistry - A European Journal. 18:5826-5831
Azabicyclic ring skeletons are common structural subunits present in numerous alkaloid natural products and serve as important scaffolds in biologically active and pharmaceutically significant compounds.[1] Of particular interest in our lab (Figure 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452ebb0854c343d25534c5f878f217f4
https://doi.org/10.1002/chem.201200629
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9
Enantioselective Total Synthesis of (+)-Amabiline
Autor: Craig W. Lindsley, Olugbeminiyi O. Fadeyi, Timothy J. Senter
Publikováno v: Organic Letters. 14:1869-1871
The first total synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile, is reported. This convergent, enantioselective synthesis proceeds in 15 steps (10-step longest linear sequence) in 6.2% overall yield and feat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e7dd80fbb2d8f3b2b0a7c7255ca81e
https://doi.org/10.1021/ol300466a
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10
ChemInform Abstract: A General, Enantioselective Synthesis of 1-Azabicyclo[m.n.0]alkane Ring Systems
Autor: Michael L. Schulte, Timothy J. Senter, Leah C. Konkol, Craig W. Lindsley, Tyler E. Wadzinski
Publikováno v: ChemInform. 44
The novel approach to the title compounds, subunits of various natural product classes, involves the highly diastereoselective allylation of sulfimine (II).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9999b176e5567e1fd2c4acd206b0724
https://doi.org/10.1002/chin.201328117
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