Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Timothy J. Sears"'
Autor:
Stephanie Hasapis, Isibel Caraballo, Timothy J. Sears, Kennedy D. Brock, John B. Cart, Everett J. Moding, Chang-Lung Lee
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The tumor suppressor p53 is a transcriptional factor that plays a crucial role in controlling acute toxicity and long-term malignant transformation of hematopoietic cells induced by genotoxic stress such as ionizing radiation. Among all tran
Externí odkaz:
https://doaj.org/article/4a5f84520fb64649acbc501f6aef2551
Autor:
Meghana Pagadala, Timothy J. Sears, Victoria H. Wu, Eva Pérez-Guijarro, Hyo Kim, Andrea Castro, James V. Talwar, Cristian Gonzalez-Colin, Steven Cao, Benjamin J. Schmiedel, Shervin Goudarzi, Divya Kirani, Jessica Au, Tongwu Zhang, Teresa Landi, Rany M. Salem, Gerald P. Morris, Olivier Harismendy, Sandip Pravin Patel, Ludmil B. Alexandrov, Jill P. Mesirov, Maurizio Zanetti, Chi-Ping Day, Chun Chieh Fan, Wesley K. Thompson, Glenn Merlino, J. Silvio Gutkind, Pandurangan Vijayanand, Hannah Carter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring cancer screening and treatment strategies. Here, we study 1084
Externí odkaz:
https://doaj.org/article/1886eb37a6cb4e559bd4787806656c26
Differential regulation of TNFα and IL-6 expression contributes to immune evasion in prostate cancer
Autor:
Ida Deichaite, Timothy J. Sears, Leisa Sutton, Daniel Rebibo, Kylie Morgan, Tyler Nelson, Brent Rose, Pablo Tamayo, Napoleone Ferrara, Fotis Asimakopoulos, Hannah Carter
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background The role of the inflammatory milieu in prostate cancer progression is not well understood. Differences in inflammatory signaling between localized and metastatic disease may point to opportunities for early intervention. Methods W
Externí odkaz:
https://doaj.org/article/6c336cad188a480dbf019d5948e67580
Autor:
Ida Deichaite, Austin Hopper, Lena Krockenberger, Timothy J. Sears, Leisa Sutton, Xenia Ray, Andrew Sharabi, Ami Navon, Parag Sanghvi, Hannah Carter, Vitali Moiseenko
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Precision medicine incorporating genetic profiling is becoming a standard of care in medical oncology. However, in the field of radiation oncology there is limited use of genetic profiling and the impact of germline genetic biomar
Externí odkaz:
https://doaj.org/article/c721a2958deb4f2f84a533c644a085e3
Autor:
Nam Q. Bui, Neda Nemat-Gorgani, Ajay Subramanian, Ileana A. Torres, Marta Lohman, Timothy J. Sears, Matt van de Rijn, Gregory W. Charville, Hans-Christoph Becker, David S. Wang, Gloria L. Hwang, Kristen N. Ganjoo, Everett J. Moding
Publikováno v:
Clinical Cancer Research.
Purpose: Immune checkpoint inhibition has led to promising responses in soft tissue sarcomas (STSs), but the majority of patients do not respond and biomarkers of response will be crucial. Local ablative therapies may augment systemic responses to im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a3dc19dbc591fde9a9745b4cb6bafd6
https://doi.org/10.1158/1078-0432.ccr-23-0250
https://doi.org/10.1158/1078-0432.ccr-23-0250
Autor:
Ajay Subramanian, Neda Nemat-Gorgani, Timothy J. Ellis-Caleo, David G.P. van IJzendoorn, Timothy J. Sears, Anish Somani, Bogdan A. Luca, Maggie Y. Zhou, Martina Bradic, Ileana A. Torres, Eniola Oladipo, Christin New, Deborah E. Kenney, Raffi S. Avedian, Robert J. Steffner, Michael S. Binkley, David G. Mohler, William D. Tap, Sandra P. D’Angelo, Matt van de Rijn, Kristen N. Ganjoo, Nam Q. Bui, Gregory W. Charville, Aaron M. Newman, Everett J. Moding
Publikováno v:
Cancer Research. 83:5960-5960
The tumor microenvironment contributes to tumorigenesis, disease progression, and response to therapy in soft tissue sarcomas (STSs). However, characterizing the malignant and stromal cells that make up STSs and correlating their abundance with clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae79e9301e5deab77611c29dfae2ce27
https://doi.org/10.1158/1538-7445.am2023-5960
https://doi.org/10.1158/1538-7445.am2023-5960
Publikováno v:
GEOPHYSICS. 75:R109-R119
Elastic full waveform inversion of multichannel seismic data represents a data-driven form of analysis leading to direct quantification of the subsurface elastic parameters in the depth domain. Previous studies have focused on marine streamer data us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::973d292fd174c5fc0b2752891984cd24
https://doi.org/10.1190/1.3484097
https://doi.org/10.1190/1.3484097