Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Timothy J. Ragan"'
Autor:
Claudia Lancey, Muhammad Tehseen, Souvika Bakshi, Matthew Percival, Masateru Takahashi, Mohamed A. Sobhy, Vlad S. Raducanu, Kerry Blair, Frederick W. Muskett, Timothy J. Ragan, Ramon Crehuet, Samir M. Hamdan, Alfredo De Biasio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Translesion Synthesis is a process that enables cells to overcome the deleterious effects of replication stalling caused by DNA lesions. Here the authors present a Cryo-EM structure of human Y-family DNA polymerase k (Pol k) bound to PCNA, P/T DNA an
Externí odkaz:
https://doaj.org/article/fcb4f0fc2e6645adb3f4b1e3da3263f8
Autor:
Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The core FADD:Caspase-8 complex and its regulatory partners, such as the cell death inhibitor c-FLIP, coordinate cell fate. Here authors present the structure of full-length procaspase-8 in a complex with FADD and reveal how recruitment of c-FLIPS in
Externí odkaz:
https://doaj.org/article/cbf43a167d5c47dbbf9efdc46a691fd7
Autor:
Claudia Lancey, Muhammad Tehseen, Vlad-Stefan Raducanu, Fahad Rashid, Nekane Merino, Timothy J. Ragan, Christos G. Savva, Manal S. Zaher, Afnan Shirbini, Francisco J. Blanco, Samir M. Hamdan, Alfredo De Biasio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Pol δ bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand in eukaryotes and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. Here, the authors present a Cryo-EM structur
Externí odkaz:
https://doaj.org/article/782ada8b374241e2b47934138793c3f7
Autor:
Ross A. Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J. Ragan, James A. West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C. Kienesberger, Ryszard T. Smolenski, Hillary K. Siddall, John L. Offer, Mihaela M. Mocanu, Derek M. Yelon, Jason R. B. Dyck, Jules L. Griffin, Andrey Y. Abramov, Alex P. Gould, Timothy J. Mohun
Publikováno v:
PLoS Biology, Vol 11, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/6a8fd36805ff492ba96d5efe8f050325
Autor:
Siyu Wang, Louise Fairall, Trong Khoa Pham, Timothy J Ragan, Dipti Vashi, Mark O Collins, Cyril Dominguez, John W R Schwabe
Publikováno v:
Nucleic Acids Research.
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition to the d
Autor:
Timothy J. Ragan, Helen A. Vincent
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630037
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c0cb624c493fd0cd222f018a21a460
https://doi.org/10.1007/978-1-0716-3004-4_6
https://doi.org/10.1007/978-1-0716-3004-4_6
Autor:
Vlad-Stefan Raducanu, Alfredo De Biasio, Souvika Bakshi, Ramon Crehuet, Masateru Takahashi, Matthew Percival, Samir M. Hamdan, Timothy J. Ragan, Frederick W. Muskett, Mohamed Abdelmaboud Sobhy, Muhammad Tehseen, Claudia Lancey, Kerry Blair
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Y-family DNA polymerase κ (Pol κ) can replicate damaged DNA templates to rescue stalled replication forks. Access of Pol κ to DNA damage sites is facilitated by its interaction with the processivity clamp PCNA and is regulated by PCNA mono-ubiquit
Autor:
Siyu Wang, Louise Fairall, Khoa Pham, Timothy J Ragan, Dipti Vashi, Mark O. Collins, Cyril Dominguez, John W.R. Schwabe
Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition to the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20775cd18bc7ac9930b379021d52e1e7
https://doi.org/10.1101/2022.07.22.501112
https://doi.org/10.1101/2022.07.22.501112
Autor:
John W.R. Schwabe, Christopher J. Millard, Christos G. Savva, Timothy J. Ragan, Louise Fairall
Publikováno v:
Nucleic Acids Research
Class I histone deacetylase complexes play essential roles in many nuclear processes. Whilst they contain a common catalytic subunit, they have diverse modes of action determined by associated factors in the distinct complexes. The deacetylase module
Publikováno v:
Journal of Biomolecular Nmr
Fragment-based drug discovery or FBDD is one of the main methods used by industry and academia for identifying drug-like candidates in early stages of drug discovery. NMR has a significant impact at any stage of the drug discovery process, from prima