Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Timothy J. R. Harris"'
Autor:
Lon R. Cardon, Timothy J. R. Harris
Publikováno v:
Human Molecular Genetics. 25:R166-R172
The hope for precision medicine has long been on the drug discovery horizon, well before the Human Genome Project gave it promise at the turn of the 21st century. In oncology, the concept has finally been realized and is now firmly embedded in ongoin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1baa508d4af287f911ec3ece238df56
https://doi.org/10.1093/hmg/ddw246
https://doi.org/10.1093/hmg/ddw246
Autor:
Timothy J. R. Harris, Jennifer Mehalko, María Ana Duhagon, Robert M. Stephens, Dominic Esposito, José R. Sotelo, Kelley Banfield, Hongling Liao, Xiaolin Wu, David J. Munroe
Publikováno v:
Proceedings of the National Academy of Sciences. 107:3001-3005
Recent genomewide association studies have found multiple genetic variants on chromosome 8q24 that are significantly associated with an increased susceptibility to prostate, colorectal, and breast cancer. These risk loci are located in a ”gene dese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9574b50fab1b29ed5ed0ad209ac735ee
https://doi.org/10.1073/pnas.0906067107
https://doi.org/10.1073/pnas.0906067107
Publikováno v:
Tetrahedron: Asymmetry. 15:2667-2679
Highly regioselective reactions of a benzylidene-protected oxetane with (i) triethylsilane-trifluoroacetic acid and (ii) Hanessian-Hullar bromination provide efficient access to 3-hydroxyoxetane carboxylates in which only the C-3 OH is unprotected. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6731905285393dcc2421f3f6301d634b
https://doi.org/10.1016/j.tetasy.2004.07.031
https://doi.org/10.1016/j.tetasy.2004.07.031
Publikováno v:
Pharmacogenetics. 10:503-510
Progress towards construction of a dense map of di-allelic markers across the human genome has generated considerable enthusiasm for pharmacogenomic applications. To date, however, nearly all of the effort on single nucleotide polymorphism (SNP) proj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c9c5f4084b45e180075a4a8c11d652
https://doi.org/10.1097/00008571-200008000-00003
https://doi.org/10.1097/00008571-200008000-00003
Autor:
Philippe Froguel, Bernard Guy-Grand, Lon R. Cardon, Florence Demenais, Timothy J. R. Harris, Karine Clément, Chad Garner, Anne Philippi, Jörg Hager, Carrie LeDuc, Alisoun H. Carey, Corinne Jury, Michael North, Arnaud Basdevant
Publikováno v:
Diabetes. 45:687-690
Obesity is one of the most significant risk factors for hypertension, coronary heart disease, and NIDDM (Frayn KN, Coppack SW: Insulin resistance, adipose tissue and coronary heart disease. Clin Sci 82:1–8, 1992; Kaplan NM: The deadly quartet: uppe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90efd4d4aec9bc002b47b6fd46fe481a
https://doi.org/10.2337/diab.45.5.687
https://doi.org/10.2337/diab.45.5.687
Autor:
David Salom, Krzysztof Palczewski, Timothy J. R. Harris, O Marcin Golczak, Ning Li, Carole Kurahara, John A. Salon, Li Zhang, Todd Juan, Steven R. Jordan, Beata Jastrzebska, Juan A. Ballesteros
Publikováno v:
Biochemistry. 46(28)
Traditional cell-based systems used to express integral membrane receptors have yet to produce protein samples of sufficient quality for structural study. Herein we report an in vivo method that harnesses the photoreceptor system of the retina to het
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0b7152f00dc6a5d0a33dea758abed2
https://pubmed.ncbi.nlm.nih.gov/17580959
https://pubmed.ncbi.nlm.nih.gov/17580959
Autor:
David Salom, Timothy J. R. Harris, Marcin Golczak, Juan A. Ballesteros, David T. Lodowski, Ronald E. Stenkamp, Beata Jastrzebska, Krzysztof Palczewski, Isolde Le Trong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(44)
The changes that lead to activation of G protein-coupled receptors have not been elucidated at the structural level. In this work we report the crystal structures of both ground state and a photoactivated deprotonated intermediate of bovine rhodopsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85e3702a333d1fad904b8a94dc5b5a4
https://pubmed.ncbi.nlm.nih.gov/17060607
https://pubmed.ncbi.nlm.nih.gov/17060607
Autor:
Geoffrey A. Cordell, Norman R. Farnsworth, Christopher W. W. Beecher, D. Doel Soejarto, A. Douglas Kinghorn, John M. Pezzuto, Monroe E. Wall, Mansukhlal C. Wani, Ronald R. Cobb, Melanie J. O’Neill, R. Murray Tait, Timothy J. R. Harris
Publikováno v:
Anticancer Drug Discovery and Development: Natural Products and New Molecular Models ISBN: 9781461361183
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b353d69df1f6a7fe431e164f37eeb5
https://doi.org/10.1007/978-1-4615-2610-0_4
https://doi.org/10.1007/978-1-4615-2610-0_4
Autor:
Geoffrey A. Cordell, Norman R. Farnsworth, Christopher W. W. Beecher, Djaja Doel Soejarto, A. Douglas Kinghorn, John M. Pezzuto, Monroe E. Wall, Mansukh C. Wani, Daniel M. Brown, Melanie J. O'Neill, Jane A. Lewis, R. Murray Tait, Timothy J. R. Harris
Publikováno v:
ACS Symposium Series ISBN: 9780841227057
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08bd2525b9acef79efccc9fa39877fe2
https://doi.org/10.1021/bk-1993-0534.ch013
https://doi.org/10.1021/bk-1993-0534.ch013
Publikováno v:
Proceedings of the National Academy of Sciences. 75:4868-4872
Virion RNA of poliovirus type 1 has been analyzed for the linkage between genome-protein VPg and the polyribonucleotide chain. Hydrolysis of the linkage with acid or alkali and enzymatic degradation lead to the conclusion that the bond is neither a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a0841fa9eb9029abb2a11efe870d84
https://doi.org/10.1073/pnas.75.10.4868
https://doi.org/10.1073/pnas.75.10.4868