Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Timothy J. O'Neill"'
Autor:
Timothy J. O'Neill
Publikováno v:
Commonwealth. 3
This research note tests the proposition that different local selection processes recruit judges with different outlooks about tile roles they aught to perform Wi democratic officials and as legal professionals. Based on interviews with ninety-four s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b895e94ce5bf67890fc53b5b5e9ede0
https://doi.org/10.15367/com.v3i1.587
https://doi.org/10.15367/com.v3i1.587
Autor:
Roland E. Dolle, Diane L. DeHaven-Hudkins, Daniel D. Wiant, Joel A. Cassel, William M. Barker, Patrick J. Little, Bertrand Le Bourdonnec, Robert N. DeHaven, Serge Belanger, Nathalie Conway-James, Timothy J. O’Neill
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2006-2012
A series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines, mu opioid receptor antagonists, analogs of alvimopan, were prepared using solid phase methodology. This study led to the identification of a highly selective mu opioid recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26c41c2d45b977ff06a701c18afedae
https://doi.org/10.1016/j.bmcl.2008.01.106
https://doi.org/10.1016/j.bmcl.2008.01.106
Autor:
I.-W. Chen, Kenneth S. Koblan, George D. Hartman, Robert B. Lobell, Theresa M. Williams, Samuel L. Graham, Jackson B. Gibbs, Ian B Greenberg, Debra A. McLoughlin, Dongming Liu, Jeffrey M. Bergman, Timothy V. Olah, C. Blair Zartman, Donna Wei, Timothy J. O'Neill, Joseph P. Davide, Nancy E. Kohl, Christopher J. Dinsmore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:537-540
The evaluation of SAR associated with the insertion of carbonyl groups at various positions of N-arylpiperazinone farnesyltransferase inhibitors is described herein. 1-Aryl-2,3-diketopiperazine derivatives exhibited the best balance of potency and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81443e20c905a2a51041cf95b6156e5
https://doi.org/10.1016/s0960-894x(00)00710-1
https://doi.org/10.1016/s0960-894x(00)00710-1
Autor:
Debra A. McLoughlin, Huff, I.-W. Chen, Kenneth S. Koblan, Baginsky Wf, Christopher J. Dinsmore, Timothy V. Olah, Timothy J. O'Neill, Zartman Cb
Publikováno v:
Organic Letters. 2:3473-3476
[reaction: see text] Synthesis of the 8-amino-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine ring system was accomplished by intramolecular cyclization of an iminium ion, derived from condensation of an amine and a substituted gamma-(1-imidazolyl)butyralde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4a9be911abd7061880d6f64db23e51
https://doi.org/10.1021/ol0002424
https://doi.org/10.1021/ol0002424
Autor:
Kenneth S. Koblan, Christopher J. Dinsmore, Jackson B. Gibbs, S. C. Mactough, J. Christopher Culberson, Terrence M. Ciccarone, Nancy E. Kohl, Samuel L. Graham, Daksha Shah, Timothy J. O'Neill, Oliff Allen I, Theresa M. Williams, George D. Hartman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1991-1996
The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Substitutions on an imidazolylmethyl-AMBA-methionine template gave a highly potent and cell-active inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c372403f5e249be893cf49da7881c4
https://doi.org/10.1016/s0960-894x(99)00323-6
https://doi.org/10.1016/s0960-894x(99)00323-6
Autor:
Theresa M. Williams, Rands E, Nancy E. Kohl, George D. Hartman, Samuel L. Graham, Kelly Hamilton, Timothy J. O'Neill, Oliff Allen I, Christopher J. Dinsmore, Kenneth S. Koblan, Jackson B. Gibbs
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1345-1348
The design and synthesis of simple nonpeptide inhibitors of farnesyl-protein transferase (FTase) are described. Cysteine-derived diarylether frameworks are appropriate structural replacements for the C -terminal tetrapeptide portion of the Ras protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dd7b69649d3202b5e1985676c23a1eb
https://doi.org/10.1016/s0960-894x(97)00225-4
https://doi.org/10.1016/s0960-894x(97)00225-4
Autor:
Timothy J. O’Neill
Publikováno v:
Problems of Post-Communism. 44:3-14
Can Hong Kong persist as a capitalist, common law enclave within a socialist regime? Uncovering current legal and business practices and customs in China’s Shenzhen province offers clues about the ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dfa8e2a1caf10eedc76cae8fc677a24
https://doi.org/10.1080/10758216.1997.11655727
https://doi.org/10.1080/10758216.1997.11655727
Autor:
Nancy E. Kohl, Charles A. Omer, Michael W. Conner, Neville J. Anthony, Joseph P. Davide, S. Jane Desolms, Elizabeth A. Giuliani, Robert P. Gomez, Samuel L. Graham, Kelly Hamilton, Laurence K. Handt, George D. Hartman, Kenneth S. Koblan, Astrid M. Kral, Patricia J. Miller, Scott D. Mosser, Timothy J. O'Neill, Elaine Rands, Michael D. Schaber, Jackson B. Gibbs, Allen Oliff
Publikováno v:
Nature Medicine. 1:792-797
For Ras oncoproteins to transform mammalian cells, they must be post-translationally modified with a farnesyl group in a reaction catalysed by the enzyme farnesyl-protein transferase (FPTase). Inhibitors of FPTase have therefore been proposed as anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0382a1f38fff17a314a1bd3e4fdea51b
https://doi.org/10.1038/nm0895-792
https://doi.org/10.1038/nm0895-792
Autor:
Robert B. Lobell, J. Christopher Culberson, Jackson B. Gibbs, Christopher J. Dinsmore, Kenneth S. Koblan, Theresa M. Williams, Nancy E. Kohl, Dongming Liu, Rands E, Timothy J. O'Neill
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6eb01d4b86d19f516aa3aa8ac4a48ae
https://doi.org/10.1002/chin.200009242
https://doi.org/10.1002/chin.200009242