Zobrazeno 1 - 10
of 449
pro vyhledávání: '"Timothy J. Mitchison"'
Autor:
Tai L. Ng, Erika J. Olson, Tae Yeon Yoo, H. Sloane Weiss, Yukiye Koide, Peter D. Koch, Nathan J. Rollins, Pia Mach, Tobias Meisinger, Trenton Bricken, Timothy Z. Chang, Colin Molloy, Jérôme Zürcher, Roger L. Chang, Timothy J. Mitchison, John I. Glass, Debora S. Marks, Jeffrey C. Way, Pamela A. Silver
Publikováno v:
mSystems, Vol 7, Iss 2 (2022)
ABSTRACT Suppression of the host innate immune response is a critical aspect of viral replication. Upon infection, viruses may introduce one or more proteins that inhibit key immune pathways, such as the type I interferon pathway. However, the abilit
Externí odkaz:
https://doaj.org/article/37ee1fa315624f72abfb551a9d58f267
Autor:
Timothy J. Mitchison
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-3 (2021)
Abstract Natural killer (NK) cells participate in cancer immunosurveillance and cancer immunotherapy. Live cell imaging of cancer cells targeted by NK cells, published today in BMC Biology by Zhu et al., reveals a remarkable diversity of programmed c
Externí odkaz:
https://doaj.org/article/c1afd6fec5b247c3ba1496124c3d6e48
Autor:
Gaurav Luthria, Ran Li, Stephanie Wang, Mark Prytyskach, Rainer H. Kohler, Douglas A. Lauffenburger, Timothy J. Mitchison, Ralph Weissleder, Miles A. Miller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modula
Externí odkaz:
https://doaj.org/article/6e12c582f93443ddbaa1e7221c686a84
Autor:
Hyun Jung Jun, Vicky A. Appleman, Hua-Jun Wu, Christopher M. Rose, Javier J. Pineda, Alan T. Yeo, Bethany Delcuze, Charlotte Lee, Aron Gyuris, Haihao Zhu, Steve Woolfenden, Agnieszka Bronisz, Ichiro Nakano, Ennio A. Chiocca, Roderick T. Bronson, Keith L. Ligon, Jann N. Sarkaria, Steve P. Gygi, Franziska Michor, Timothy J. Mitchison, Al Charest
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Amplification of PDGFRα is a common alteration in glioblastoma. In this study, the authors develop a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFR and discover Stathmin1 as an important PDGF
Externí odkaz:
https://doaj.org/article/e36e588f60e24fb6aa72e07d8947fc7d
Autor:
Stefan Florian, Timothy J. Mitchison
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 6 (2019)
We have discovered an organoid culture approach that recapitulates morphology and coordinated development of a benign breast tumor. This system may be useful to groups investigating normal mammary gland biology and coordination of collective cell beh
Externí odkaz:
https://doaj.org/article/37d9711a6e65442d8386b4566ed80173
Autor:
Ivana Gasic, Brian J. Groendyke, Radosław P. Nowak, J. Christine Yuan, Joann Kalabathula, Eric S. Fischer, Nathanael S. Gray, Timothy J. Mitchison
Publikováno v:
Cells, Vol 9, Iss 5, p 1083 (2020)
Dysregulation of microtubules and tubulin homeostasis has been linked to developmental disorders, neurodegenerative diseases, and cancer. In general, both microtubule-stabilizing and destabilizing agents have been powerful tools for studies of microt
Externí odkaz:
https://doaj.org/article/8f2efcf24a734af485421f5c3d76b50b
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1808-1818 (2014)
Poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribose) addition onto proteins, an important posttranslational modification involved in transcription, DNA damage repair, and stem cell identity. Previous studies established the activation of PA
Externí odkaz:
https://doaj.org/article/9a74eeeafbc34a3989a4ce63c759f033
Autor:
Rui Tong Quek, Kierra S. Hardy, Stephen G. Walker, Dan T. Nguyen, Taciani de Almeida Magalhães, Adrian Salic, Sujatha M. Gopalakrishnan, Pamela A. Silver, Timothy J. Mitchison
Publikováno v:
ACS Chemical Biology. 18:583-594
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Fig. S1 from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0595d9ccc193c5c4dd6436ba0d3685f7
https://doi.org/10.1158/1535-7163.22483554
https://doi.org/10.1158/1535-7163.22483554
Autor:
Timothy J. Mitchison, Frank T. Zenke, Claudia Wilm, Christiane Amendt, Clement T. Loy, Jade Shi, Yangzhong Tang, James D. Orth
Supplementary Methods from Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f4016373736a2af88b93a483de1380
https://doi.org/10.1158/1535-7163.22483524
https://doi.org/10.1158/1535-7163.22483524