Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Timothy J. Miles"'
Autor:
Caterina Pont, Elisabet Viayna, Stephen Brand, Ian H. Gilbert, Peter George Dodd, Iva Lukac, Laste Stojanovski, Maria Osuna-Cabello, Jennifer Riley, Sujatha Manthri, Kate McGonagle, Timothy J. Miles, Julio Martin, Fabio Zuccotto, Frederick R. C. Simeons, John Thomas, Maria L. Marco, Paul G. Wyatt, Kevin D. Read, Stephen Thompson, Jose M. Fiandor, Michael G. Thomas, Manu De Rycker, Eun-Jung Ko
Publikováno v:
Journal of Medicinal Chemistry
There is an urgent need for new treatments for visceral leishmaniasis (VL), a parasitic infection which impacts heavily large areas of East Africa, Asia, and South America. We previously reported on the discovery of GSK3494245/DDD01305143 (1) as a pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023548cc95d4d9c556b1402e19227eb9
http://europepmc.org/articles/PMC8154566
http://europepmc.org/articles/PMC8154566
Autor:
Michael G. Thomas, Maria L. Marco, John Thomas, Daniel Spinks, Ian H. Gilbert, Laste Stojanovski, Frederick R. C. Simeons, Ola Epemolu, Sujatha Manthri, Claire Naylor, Timothy J. Miles, Manu De Rycker, Suzanne Norval, Susan Wyllie, Stephen Patterson, Jennifer Riley, Maria Osuna-Cabello, Richard J. Wall, Jose M. Fiandor, Paul G. Wyatt, Kevin D. Read, Stephen Thompson
Publikováno v:
Journal of Medicinal Chemistry. 63:9523-9539
Visceral leishmaniasis (VL) is a parasitic infection that results in approximately 26 000–65 000 deaths annually. The available treatments are hampered by issues such as toxicity, variable efficacy...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2075363d9d5006cac4eca5979afbbe9
https://doi.org/10.1021/acs.jmedchem.0c00705
https://doi.org/10.1021/acs.jmedchem.0c00705
Autor:
Ian H. Gilbert, Sandra Carvalho, Stephen Thompson, Lorna MacLean, Fabio Zuccotto, Susan Wyllie, Timothy J. Miles, Lalitha Sastry, Ignacio Cotillo, Manu De Rycker, Juan A. Bueren-Calabuig, Sonia Moniz, Rachel Milne, Albane Kessler, Maria L. Marco, Julio Martin, Richard J. Wall, Alan H. Fairlamb, Juan Cantizani-Perez, Michael G. Thomas, Stephen Patterson, Sujatha Manthri
Publikováno v:
ACS Infectious Diseases
Available treatments for Chagas' disease and visceral leishmaniasis are inadequate, and there is a pressing need for new therapeutics. Drug discovery efforts for both diseases principally rely upon phenotypic screening. However, the optimization of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbdbdb72ed0d785ae1f89aec7a44bf2
http://europepmc.org/articles/PMC7076694
http://europepmc.org/articles/PMC7076694
Autor:
Kevin D. Read, Sabrinia D. Crouch, Juan Miguel-Siles, Stephen Thompson, Lorna MacLean, Timothy J. Miles, Franck Martin, Alain Claude-Marie Daugan, Suzanne Norval, Laste Stojanovski, Gloria Fra, John Thomas, Frederick R. C. Simeons, Sujatha Manthri, Jose M. Fiandor, César Guerrero, Myriam Ajakane, Maria Osuna-Cabello, Paul G. Wyatt, Manu De Rycker, Lorna Campbell, Claire J. MacKenzie, Ian H. Gilbert, Jennifer Riley, Yoko Shishikura, Michael G. Thomas, Raul F. Velasco
Publikováno v:
RSC Medicinal Chemistry. 11:1168-1177
Visceral leishmaniasis (VL) affects millions of people across the world, largely in developing nations. It is fatal if left untreated and the current treatments are inadequate. As such, there is an urgent need for new, improved medicines. In this pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::907889087930243eaf8e578bd0ada172
https://doi.org/10.1039/d0md00203h
https://doi.org/10.1039/d0md00203h
Autor:
Jen Southern, Maria Jose Lafuente-Monasterio, Pottage John C, Caitlin Taylor, William W. Hope, Srinivasa P. S. Rao, Didier Leroy, Jennifer Keiser, Sarah Cook, Clifton E. Barry, John P. Overington, Paul Herrling, Shyam Sundar, Olena Moshynets, David Horn, Lynn L. Silver, Valerie Mizrahi, Manu De Rycker, Isabela Ribeiro, Thomas Spangenberg, Ujjini H. Manjunatha, Nathalie Gobeau, Paul D. Leeson, Jacquin C. Niles, Nicholas J. White, Kevin D. Read, Susan Wyllie, Timothy J. Miles, Richard Amewu, Ian H. Gilbert, Frederick S. Buckner, Wesley C. Van Voorhis, James S. McCarthy, Paul G. Wyatt, Jennifer Herrmann, Michael A. J. Ferguson, Bree B. Aldridge
Publikováno v:
ACS Infectious Diseases
ACS infectious diseases
ACS INFECTIOUS DISEASES
ACS infectious diseases
ACS INFECTIOUS DISEASES
In May 2019, the Wellcome Centre for Anti-Infectives Research (; W; CAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4aded55419b192e43a1d93bef190a7b
https://eprints.gla.ac.uk/205951/1/205951.pdf
https://eprints.gla.ac.uk/205951/1/205951.pdf
Autor:
Manu De Rycker, John Thomas, Michael G. Thomas, Timothy J. Miles, Paul G. Wyatt, Ignacio Cotillo Torrejon, Kevin D. Read, Jennifer Riley, Daniel Spinks, Ian H. Gilbert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3025-3030
Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, affects 8–10 million people across the Latin American population and is responsible for around 12,500 deaths per annum. The current frontline treatments, benznidazole and nifurt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2ae21b584c56a4ef49173602a4cc47
https://doi.org/10.1016/j.bmcl.2018.08.005
https://doi.org/10.1016/j.bmcl.2018.08.005
Autor:
Laste Stojanovski, Tania Bakshi, Iain H. Reid, Maria L. Marco, Stephen Brand, Lars Henrik Sandberg, Sabrinia D. Crouch, Ian H. Gilbert, Lorna MacLean, Jennifer Riley, Christopher J. Nixon, Sharon Robinson, John M. Kelly, Yoko Shishikura, Stephen Thompson, Eun Jung Ko, Kevin D. Read, Daniel Spinks, Jose M. Fiandor, John Thomas, Alan P. Hill, Amanda F. Francisco, Ola Epemolu, Victoria Smith, Chimed Jansen, Paul G. Wyatt, Elisabet Viayna, Sean J. Hindley, Timothy J. Miles, Shiromani Jayawardhana, Frederick R. C. Simeons, Michael G. Thomas, Manu De Rycker, Tim Underwood, Paul Scullion, Maria Osuna-Cabello
Publikováno v:
Journal of Medicinal Chemistry
Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, is the most common cause of cardiac-related deaths in endemic regions of Latin America. There is an urgent need for new safer treatments because current standard therapeutic options
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8f828f15d0a52e1f719409da74fd5b
http://europepmc.org/articles/PMC5601362
http://europepmc.org/articles/PMC5601362
Autor:
Graham Elgin Jones, Alan Joseph Hennessy, Steve Rittenhouse, Ilaria Giordano, Roger Edward Markwell, Steven Dabbs, Michael N. Gwynn, David T. Davies, Jennifer Hoover, Nathalie Cailleau, Barry S. Brown, Joel Michael Esken, Neil D. Pearson, Pamela Brown, Dongzhao Chen, Elisabeth A. Minthorn, Ben Bax, Gerald Brooks, Timothy J. Miles, Senthill K. Kusalakumari Sukmar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2464-2469
During the course of our research on the lead optimisation of the NBTI (Novel Bacterial Type II Topoisomerase Inhibitors) class of antibacterials, we discovered a series of tricyclic compounds that showed good Gram-positive and Gram-negative potency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f67eb26144e4e029d7a0d4e17988e6f
https://doi.org/10.1016/j.bmcl.2016.03.106
https://doi.org/10.1016/j.bmcl.2016.03.106
Autor:
Stephanie Gresham, Stephen Patterson, Laste Stojanovski, Fabio Zuccotto, Susan Wyllie, Matthew Berriman, Timothy J. Miles, Frederick R. C. Simeons, Nadine Homeyer, Lorna MacLean, Paul Connolly, Lalitha Sastry, Manu De Rycker, Rhiannon Lowe, Gerard Drewes, Sabrinia D. Crouch, David W. Gray, Thomas D. Otto, Sebastian Albrecht, Michael G. Thomas, Michael A. J. Ferguson, Sujatha Manthri, Michael D. Urbaniak, Markus Boesche, Hannah Pflaumer, Alan H. Fairlamb, Ian H. Gilbert, Sonja Ghidelli-Disse, Kevin D. Read, Paul G. Wyatt, Jose M. Fiandor, Susan Dixon
Publikováno v:
Nature
Visceral leishmaniasis causes considerable mortality and morbidity in many parts of the world. There is an urgent need for the development of new, effective treatments for this disease. Here we describe the development of an anti-leishmanial drug-lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6f9bff9da702dd0f4d789ce1ce05a4
https://pubmed.ncbi.nlm.nih.gov/30076375
https://pubmed.ncbi.nlm.nih.gov/30076375
Organolithium-induced ring-opening of aziridines of 2,5-dihydrofuran (5 and 8) and 1,4-dimethoxybut-2-ene (16, 17 and 23) gives 3-substituted 2-aminobut-3-en-1-ols 9–15 and amino ethers 18–20 and 24–26.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11c43239b915733c3e16cb4d46a6ea4
https://doi.org/10.1039/b409486g
https://doi.org/10.1039/b409486g