Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Timothy J. Mead"'
Autor:
Oscar van derHave, Timothy J. Mead, Christian Westöö, Niccolò Peruzzi, Ayse C. Mutgan, Christian Norvik, Martin Bech, André Struglics, Konrad Hoetzenecker, Hans Brunnström, Gunilla Westergren‐Thorsson, Grazyna Kwapiszewska, Suneel S. Apte, Karin Tran‐Lundmark
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Expansion of extracellular matrix occurs in all stages of pulmonary angiopathy associated with pulmonary arterial hypertension (PAH). In systemic arteries, dysregulation and accumulation of the large chondroitin‐sulfate proteoglycan aggrec
Externí odkaz:
https://doaj.org/article/9ec517eecbfa42948ac1c94d671fac5f
Autor:
Timothy J. Mead
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
ADAMTS family members control mammalian development and disease, primarily through their function as proteases, by regulation of extracellular matrix composition. Until recently, ADAMTS6 was known as one of the orphan proteinases of the nineteen-memb
Externí odkaz:
https://doaj.org/article/c3e9cd985fc14eb8981c206a1ede2cc4
Autor:
Dalya Ataca, Patrick Aouad, Céline Constantin, Csaba Laszlo, Manfred Beleut, Marie Shamseddin, Renuga Devi Rajaram, Rachel Jeitziner, Timothy J. Mead, Marian Caikovski, Philipp Bucher, Giovanna Ambrosini, Suneel S. Apte, Cathrin Brisken
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
How hormonal signaling in the mammary epithelium controls the surrounding extracellular matrix is unclear. Here, the authors show that a secreted protease, Adamts18, induced by upstream estrogen-progesterone activated Wnt4 in myoepithelial cells, rem
Externí odkaz:
https://doaj.org/article/d8bdc001db1a46d1897587347f7e2b51
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Autor:
Bram P. Prins, Timothy J. Mead, Jennifer A. Brody, Gardar Sveinbjornsson, Ioanna Ntalla, Nathan A. Bihlmeyer, Marten van den Berg, Jette Bork-Jensen, Stefania Cappellani, Stefan Van Duijvenboden, Nikolai T. Klena, George C. Gabriel, Xiaoqin Liu, Cagri Gulec, Niels Grarup, Jeffrey Haessler, Leanne M. Hall, Annamaria Iorio, Aaron Isaacs, Ruifang Li-Gao, Honghuang Lin, Ching-Ti Liu, Leo-Pekka Lyytikäinen, Jonathan Marten, Hao Mei, Martina Müller-Nurasyid, Michele Orini, Sandosh Padmanabhan, Farid Radmanesh, Julia Ramirez, Antonietta Robino, Molly Schwartz, Jessica van Setten, Albert V. Smith, Niek Verweij, Helen R. Warren, Stefan Weiss, Alvaro Alonso, David O. Arnar, Michiel L. Bots, Rudolf A. de Boer, Anna F. Dominiczak, Mark Eijgelsheim, Patrick T. Ellinor, Xiuqing Guo, Stephan B. Felix, Tamara B. Harris, Caroline Hayward, Susan R. Heckbert, Paul L. Huang, J. W. Jukema, Mika Kähönen, Jan A. Kors, Pier D. Lambiase, Lenore J. Launer, Man Li, Allan Linneberg, Christopher P. Nelson, Oluf Pedersen, Marco Perez, Annette Peters, Ozren Polasek, Bruce M. Psaty, Olli T. Raitakari, Kenneth M. Rice, Jerome I. Rotter, Moritz F. Sinner, Elsayed Z. Soliman, Tim D. Spector, Konstantin Strauch, Unnur Thorsteinsdottir, Andrew Tinker, Stella Trompet, André Uitterlinden, Ilonca Vaartjes, Peter van der Meer, Uwe Völker, Henry Völzke, Melanie Waldenberger, James G. Wilson, Zhijun Xie, Folkert W. Asselbergs, Marcus Dörr, Cornelia M. van Duijn, Paolo Gasparini, Daniel F. Gudbjartsson, Vilmundur Gudnason, Torben Hansen, Stefan Kääb, Jørgen K. Kanters, Charles Kooperberg, Terho Lehtimäki, Henry J. Lin, Steven A. Lubitz, Dennis O. Mook-Kanamori, Francesco J. Conti, Christopher H. Newton-Cheh, Jonathan Rosand, Igor Rudan, Nilesh J. Samani, Gianfranco Sinagra, Blair H. Smith, Hilma Holm, Bruno H. Stricker, Sheila Ulivi, Nona Sotoodehnia, Suneel S. Apte, Pim van der Harst, Kari Stefansson, Patricia B. Munroe, Dan E. Arking, Cecilia W. Lo, Yalda Jamshidi
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the varia
Externí odkaz:
https://doaj.org/article/90c79bdbde864108a63e5a86f193c9b6
Autor:
Timothy J. Mead, Yaoyao Du, Courtney M. Nelson, Ndeye-Aicha Gueye, Judith Drazba, Carolyn M. Dancevic, Mireille Vankemmelbeke, David J. Buttle, Suneel S. Apte
Publikováno v:
Cell Reports, Vol 23, Iss 2, Pp 485-498 (2018)
Summary: Focal adhesions anchor cells to extracellular matrix (ECM) and direct assembly of a pre-stressed actin cytoskeleton. They act as a cellular sensor and regulator, linking ECM to the nucleus. Here, we identify proteolytic turnover of the anti-
Externí odkaz:
https://doaj.org/article/608e794dc4a14877a77c304ed6fb224e
Autor:
Timothy J Mead, Daniel R Martin, Lauren W Wang, Stuart A Cain, Cagri Gulec, Elisabeth Cahill, Joseph Mauch, Dieter Reinhardt, Cecilia Lo, Clair Baldock, Suneel S Apte
Publikováno v:
eLife, Vol 11 (2022)
The embryonic extracellular matrix (ECM) undergoes transition to mature ECM as development progresses, yet few mechanisms ensuring ECM proteostasis during this period are known. Fibrillin microfibrils are macromolecular ECM complexes serving structur
Externí odkaz:
https://doaj.org/article/5a97c8b12bf54934ac67208635fbd524
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C651-C665
Proteoglycans are composite molecules comprising a protein backbone, i.e., the core protein, with covalently attached glycosaminoglycan chains of distinct chemical types. Most proteoglycans are secreted or attached to the cell membrane. Their special
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69c89ea353b1a8b849ce333a5ed7699
https://doi.org/10.1152/ajpcell.00215.2022
https://doi.org/10.1152/ajpcell.00215.2022
Autor:
Timothy J Mead, Daniel R Martin, Lauren W Wang, Stuart A Cain, Cagri Gulec, Elisabeth Cahill, Joseph Mauch, Dieter Reinhardt, Cecilia Lo, Clair Baldock, Suneel S Apte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f43e3964aa0b48a62f53a263799cf48b
https://doi.org/10.7554/elife.71142.sa2
https://doi.org/10.7554/elife.71142.sa2
Autor:
Cahill E, Clair Baldock, Timothy J. Mead, Martin Dr, Gulec C, Suneel S. Apte, Dieter P. Reinhardt, Stuart A. Cain, Lauren W. Wang, Mauch J, Cecilia W. Lo
The embryonic extracellular matrix (ECM) undergoes transition to mature ECM as development progresses, yet specific transition mechanisms ensuring ECM proteostasis and their regulatory impact are poorly defined. Fibrillin microfibrils are macromolecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1a01557306dcfe41b5e59efccc57c5
https://doi.org/10.1101/2021.02.03.429587
https://doi.org/10.1101/2021.02.03.429587
Autor:
Timothy J. Mead, Urszula Hibner, Sylvie Richelme, Fabrice Daian, Damien Grégoire, Ahmed Abdouni, Anthony Lozano, María Arechederra, Sehrish K. Bazai, Rosanna Dono, Celia Sequera, Suneel S. Apte, Flavio Maina, Stéphane Audebert, Daniela S. Allende
Publikováno v:
Journal of Hepatology
Journal of Hepatology, Elsevier, 2020, ⟨10.1016/j.jhep.2020.11.008⟩
Journal of Hepatology, 2021, ⟨10.1016/j.jhep.2020.11.008⟩
Journal of Hepatology, Elsevier, 2020, ⟨10.1016/j.jhep.2020.11.008⟩
Journal of Hepatology, 2021, ⟨10.1016/j.jhep.2020.11.008⟩
Background & Aims The tumour microenvironment shapes tumour growth through cellular communications that include both direct interactions and secreted factors. The aim of this study was to characterize the impact of the secreted glycoprotein ADAMTSL5,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdb4960f469c2367eace3d3b64537a9
https://hal.archives-ouvertes.fr/hal-03049722
https://hal.archives-ouvertes.fr/hal-03049722