Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Timothy J. McMahon"'
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Metabolic homeostasis in animals depends critically on evolved mechanisms by which red blood cell (RBC) hemoglobin (Hb) senses oxygen (O2) need and responds accordingly. The entwined regulation of ATP production and antioxidant systems within the RBC
Externí odkaz:
https://doaj.org/article/67fa7c62e8d74728b42454c90f430fd9
Autor:
Timothy J. McMahon, Siqing Shan, Daniel A. Riccio, Milena Batchvarova, Hongmei Zhu, Marilyn J. Telen, Rahima Zennadi
Publikováno v:
Blood Advances, Vol 3, Iss 17, Pp 2586-2597 (2019)
Abstract: Sickle red blood cells (SSRBCs) are adherent to the endothelium, activate leukocyte adhesion, and are deficient in bioactive nitric oxide (NO) adducts such as S-nitrosothiols (SNOs), with reduced ability to induce vasodilation in response t
Externí odkaz:
https://doaj.org/article/ebbd5e9300b74895b8a22bfcb513bd1f
Autor:
Timothy J. McMahon
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Healthy red blood cells (RBCs) deform readily in response to shear stress in the circulation, facilitating their efficient passage through capillaries. RBCs also export vasoactive mediators in response to deformation and other physiological and patho
Externí odkaz:
https://doaj.org/article/9d25f43a9b2e4204b69fe431fd5956a9
Publikováno v:
Blood. 140:8564-8565
Autor:
Eduardo R. Lazarowski, Brett S. Kirby, Matthew A. Sparks, Denise A Lopez Domowicz, Hongmei Zhu, Timothy J. McMahon
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H1055-H1065
Export of vasodilator ATP from red blood cells requires pannexin 1. Blood plasma ATP elevations in response to hypoxia in mice require pannexin 1. Hemodynamic responses to hypoxia are accompanied by increased plasma ATP in mice in vivo and require pa
Autor:
Yueli Liu, Laura E. Hesse, Morgan K. Geiger, Kurt R. Zinn, Timothy J. McMahon, Chengpeng Chen, Dana M. Spence
Publikováno v:
Lab Chip
A set of 3D-printed analytical devices were developed to investigate erythrocytes (ERYs) processed in conventional and modified storage solutions used in transfusion medicine. During storage prior to transfusion into a patient recipient, ERYs undergo
Autor:
Madison J. Bolejack, Peter J. Myler, Fiorella Ruchti, Ci Fu, Olivia Donovan, David A. Fox, Marco A. Coelho, Hayden Smutney, Joseph Heitman, Giuseppe Ianiri, Fred S. Dietrich, Timothy J. McMahon, Salomé LeibundGut-Landmann, Florian Sparber
Publikováno v:
Proceedings of the National Academy of Sciences. 117:15884-15894
The skin of humans and animals is colonized by commensal and pathogenic fungi and bacteria that share this ecological niche and have established microbial interactions. Malassezia are the most abundant fungal skin inhabitant of warm-blooded animals a
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology, Vol 12 (2021)
Metabolic homeostasis in animals depends critically on evolved mechanisms by which red blood cell (RBC) hemoglobin (Hb) senses oxygen (O2) need and responds accordingly. The entwined regulation of ATP production and antioxidant systems within the RBC
Autor:
Siqing Shan, Rahima Zennadi, Timothy J. McMahon, Daniel A. Riccio, Hongmei Zhu, Marilyn J. Telen, Milena Batchvarova
Publikováno v:
Blood Advances. 3:2586-2597
Sickle red blood cells (SSRBCs) are adherent to the endothelium, activate leukocyte adhesion, and are deficient in bioactive nitric oxide (NO) adducts such as S-nitrosothiols (SNOs), with reduced ability to induce vasodilation in response to hypoxia.
Autor:
Brett S, Kirby, Matthew A, Sparks, Eduardo R, Lazarowski, Denise A, Lopez Domowicz, Hongmei, Zhu, Timothy J, McMahon
Publikováno v:
Am J Physiol Heart Circ Physiol
Pannexin 1 (Panx1) channels export ATP and may contribute to increased concentration of the vasodilator ATP in plasma during hypoxia in vivo. We hypothesized that Panx1 channels and associated ATP export contribute to hypoxic vasodilation, a mechanis