Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Timothy J. Grunkemeyer"'
Autor:
Ayesha M. Patel, Karl J. Koebke, Timothy J. Grunkemeyer, Colleen M. Riordan, Youngsoo Kim, Ryan C. Bailey, E. Neil G. Marsh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Viperin is a radical S-adenosylmethionine enzyme that catalyzes the formation of the antiviral ribonucleotide, 3’-deoxy-3’,4’-didehydroCTP. The enzyme is conserved across all kingdoms of life, and in higher animals viperin is localized
Externí odkaz:
https://doaj.org/article/bf20f6509eeb4dff83e8abb04e467a1d
Autor:
Robert T. Kennedy, Timothy J. Grunkemeyer, Keerthi Sajja, Alexey I. Nesvizhskii, J. Windak, Ayesha M. Patel, E. N. G. Marsh, Youngsoo Kim, Venkatesha Basrur, Soumi Ghosh
Many enveloped viruses bud from cholesterol-rich lipid rafts on the cell membrane. Depleting cellular cholesterol impedes this process and results in viral particles with reduced viability. Viperin (virus inhibitory protein endoplasmic reticulum-asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e424b9834360a63db8b7466d512600b
https://doi.org/10.1101/2021.02.19.431989
https://doi.org/10.1101/2021.02.19.431989
Autor:
Soumi Ghosh, Robert T. Kennedy, Timothy J. Grunkemeyer, E. Neil G. Marsh, Arti B. Dumbrepatil, Kelcie A. Zegalia, Ayesha M. Patel
Publikováno v:
Biochemistry. 59(6)
The radical SAM enzyme, viperin, exerts a wide range of antiviral effects through both the synthesis of the antiviral nucleotide 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) and through its interactions with various cellular and viral proteins. Here we inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708641c5ba8ccb81d45764f095b228ae
https://pubmed.ncbi.nlm.nih.gov/31977203
https://pubmed.ncbi.nlm.nih.gov/31977203
Autor:
E. Neil G. Marsh, Ayesha M. Patel, James Windak, Robert T. Kennedy, Youngsoo Kim, Keerthi Sajja, Alexey I. Nesvizhskii, Timothy J. Grunkemeyer, Soumi Ghosh, Venkatesha Basrur
Publikováno v:
The Journal of Biological Chemistry
Many enveloped viruses bud from cholesterol-rich lipid rafts on the cell membrane. Depleting cellular cholesterol impedes this process and results in viral particles with reduced viability. Viperin (Virus Inhibitory Protein, Endoplasmic Reticulum-ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29fc9694a264e3862b0e6cfaac455c5
https://doi.org/10.1016/j.jbc.2021.100824
https://doi.org/10.1016/j.jbc.2021.100824
Autor:
E. N. G. Marsh, Ayesha M. Patel, Timothy J. Grunkemeyer, K. Zagalia, Arti B. Dumbrepatil, Soumi Ghosh, Robert T. Kennedy
The radical SAM enzyme viperin exerts a wide range of antiviral effects through both the synthesis of the antiviral nucleotide 3’-deoxy-3’, 4’-didehydro-CTP (ddhCTP) and through its interactions with various cellular and viral proteins. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c5a8a7bfc71ff67afb1e62896c4d1f
https://doi.org/10.1101/824458
https://doi.org/10.1101/824458
Autor:
Thomas J. Magliery, Timothy J. Grunkemeyer, Kiran Kumar Doddapaneni, David G. Mata, Srividya Murali
Publikováno v:
Biochemistry.
The mammalian protein paraoxonase-1 (PON1) has been explored as a promising bioscavenger treatment for organophosphorus (OP) agent poisoning, but it is not active enough to protect against many agents. Engineering is limited because PON1's catalytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e223629c1eb949b3f4e73df760d87e41
https://pubmed.ncbi.nlm.nih.gov/30547569
https://pubmed.ncbi.nlm.nih.gov/30547569
Autor:
Liqing Chen, Rebekka M. Wachter, Raimund Fromme, Taisong Zou, Timothy J. Grunkemeyer, Katerina Dörner, S. Banu Ozkan, Hanseong Kim, Mikhail V. Matz, Chintan K. Modi
Publikováno v:
Structure. 23:34-43
SummaryIn proteins, functional divergence involves mutations that modify structure and dynamics. Here we provide experimental evidence for an evolutionary mechanism driven solely by long-range dynamic motions without significant backbone adjustments,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539915d4c8f6f6a9e4fbdf018482570d
https://doi.org/10.1016/j.str.2014.11.011
https://doi.org/10.1016/j.str.2014.11.011
Autor:
Rebekka M. Wachter, Raimund Fromme, Timothy J. Grunkemeyer, Hanseong Kim, Chintan K. Modi, Mikhail V. Matz, Liqing Chen
Publikováno v:
Biochemistry. 52:8048-8059
In green-to-red photoconvertible fluorescent proteins, a three-ring chromophore is generated by the light-activated incorporation of a histidine residue into the conjugated π-system. We have determined the pH-rate profile and high- and low-pH X-ray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a2ed337a35e2e463a14b5fab09a8ed
https://doi.org/10.1021/bi401000e
https://doi.org/10.1021/bi401000e