Zobrazeno 1 - 2
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pro vyhledávání: '"Timothy J. Fattor"'
Autor:
Michael P. Doyle, John S. Olson, Douglas D. Lemon, Timothy J. Fattor, Daniel H. Doherty, Shawn R. Curry, Rita J. Vali
Publikováno v:
Nature Biotechnology. 16:672-676
Administration of extracellular hemoglobin-based oxygen carriers often induces mild increases in blood pressure. In order to test whether nitric oxide (NO) scavenging is responsible for the hypertensive effect, we constructed and tested a set of reco
Publikováno v:
Analytical biochemistry. 284(2)
We report the utility of native-state mass spectrometry to detect zinc ion binding to the engineered hemoglobin rHb52. Various preparations of this recombinant hemoglobin had significantly different oxygen affinities. Detailed characterization of den