Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Timothy J. Colby"'
Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration
Autor:
Timothy J. Colby, Yan Liu, Mark D. Erion, Qun Dang, Paul D. van Poelje, Robert M. Rydzewski, Brian S. Brown, Edward D. Robinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3412-3416
A series of substituted bis[(para-methoxy)benzyl] (bisPMB) esters of 1-naphthalenemethylphosphonate (NMPA) were synthesized and evaluated as phosphonate prodrugs. BisPMB NMPA esters (4b and 4c) with significantly improved aqueous stability were ident
Publikováno v:
Biochemistry. 32:5733-5738
In addition to the two human interleukin-8 (IL-8) receptors that have been cloned, IL-8RA and IL-8RB, we recently described a binding protein in human erythrocytes that binds IL-8 and monocyte chemotactic peptide-1 (MCP-1), which we have termed the c
Publikováno v:
ChemInform. 30
A new prodrug approach for intracellular delivery of phosphonates was developed via the synthesis of 3-phthalidyl esters of 1-naphthalenemethylphosphonate. This approach is advantageous over the traditional acyloxymethyl phosphonate prodrugs, because
Autor:
Jay DaRe, Serge H. Boyer, Timothy J. Colby, Paul D. van Poelje, Mark D. Erion, Kristin Ollis, William Craigo, Zhili Sun, Michael C Matelich, Jorge E. Gomez-Galeno, James M. Fujitaki, K. Raja Reddy, Bheemarao G Ugarkar
Publikováno v:
Journal of medicinal chemistry. 51(3)
Adefovir dipivoxil, a marketed drug for the treatment of hepatitis B, is dosed at submaximally efficacious doses because of renal toxicity. In an effort to improve the therapeutic index of adefovir, 1-aryl-1,3-propanyl prodrugs were synthesized with
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 24(5-7)
A new class of phosphate and phosphonate prodrugs, called HepDirect™ prodrugs, has been developed to deliver drugs to the liver while simultaneously diminishing drug exposure to extra-hepatic tissues. The technology combines liver-selective cleavag
Publikováno v:
Journal of molecular biology. 242(3)
The solution structure of melanoma growth stimulating activity (MGSA), a dimeric chemokine consisting of 73 residues per monomer, has been determined using two-dimensional homonuclear and three-dimensional heteronuclear NMR spectroscopy. Structure ca
Publikováno v:
FEBS letters. 330(3)
The solution structure of melanoma growth stimulating activity (MGSA) has been investigated using proton NMR spectroscopy. Sequential resonance assignments have been carried out, and elements of secondary structure have been identified on the basis o
Autor:
Timothy J. Colby, Chetan E. Chitnis, Terence J. Hadley, Walter C. Darbonne, Richard Horuk, Anne C Rybicki, Louis H. Miller
Publikováno v:
Science (New York, N.Y.). 261(5125)
Plasmodium vivax and P. falciparum are the major causes of human malaria, except in sub-Saharan Africa where people lack the Duffy blood group antigen, the erythrocyte receptor for P. vivax. Duffy negative human erythrocytes are resistant to invasion
Autor:
K. Raja Reddy, Michael C. Matelich, Bheemarao G. Ugarkar, Jorge E. Gómez-Galeno, Jay DaRe, Kristin Ollis, Zhili Sun, William Craigo, Timothy J. Colby, James M. Fujitaki, Serge H. Boyer, Paul D. van Poelje, Mark D. Erion
Publikováno v:
Journal of Medicinal Chemistry; Jan2008, Vol. 51 Issue 3, p666-676, 11p