Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Timothy J. Bussey"'
Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer’s model mice
Autor:
So Yeon Cho, Eun Woo Kim, Soo Jin Park, Benjamin U. Phillips, Jihyeon Jeong, Hyunjeong Kim, Christopher J. Heath, Daehwan Kim, Yurim Jang, Laura López-Cruz, Lisa M. Saksida, Timothy J. Bussey, Do Yup Lee, Eosu Kim
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Metformin, a primary anti-diabetic medication, has been anticipated to provide benefits for Alzheimer’s disease (AD), also known as “type 3 diabetes”. Nevertheless, some studies have demonstrated that metformin may trigger AD pathology
Externí odkaz:
https://doaj.org/article/fb57a506ec6e4434861058289b715df9
Autor:
Sara Memar, Eric Jiang, Vania F. Prado, Lisa M. Saksida, Timothy J. Bussey, Marco A. M. Prado
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Open access to rodent cognitive data has lagged behind the rapid generation of large open-access datasets in other areas of neuroscience, such as neuroimaging and genomics. One contributing factor has been the absence of uniform standardizat
Externí odkaz:
https://doaj.org/article/1935e4365c724f179b5f09c6b0cbce55
Autor:
Miguel Skirzewski, Oren Princz-Lebel, Liliana German-Castelan, Alycia M. Crooks, Gerard Kyungwook Kim, Sophie Henke Tarnow, Amy Reichelt, Sara Memar, Daniel Palmer, Yulong Li, R. Jane Rylett, Lisa M. Saksida, Vania F. Prado, Marco A. M. Prado, Timothy J. Bussey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Nucleus accumbens cholinergic interneurons release acetylcholine and glutamate. Here, authors show that acetylcholine, rather than glutamate, is predominantly involved in updating dopamine dynamics mediating Pavlovian approach behaviours.
Externí odkaz:
https://doaj.org/article/f4d1dc4e75374f81957db4a31c2850f0
Autor:
Amy C. Reichelt, Claire A. Lemieux, Oren Princz-Lebel, Ashmita Singh, Timothy J. Bussey, Lisa M. Saksida
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Emergent evidence demonstrates that excessive consumption of high fat and high sugar (HFHS) diets has negative consequences on hippocampal and prefrontal cortex (PFC) function. Moreover, the delayed maturation of the PFC including the late d
Externí odkaz:
https://doaj.org/article/d825032133824eaea89aa5923ee80632
Autor:
Jisoo Lim, Eosu Kim, Hyun Jong Noh, Shinwon Kang, Benjamin U. Phillips, Dong Goo Kim, Timothy J. Bussey, Lisa Saksida, Christopher J. Heath, Chul Hoon Kim
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility. Many of these studies involved exposing mice to highly stressful
Externí odkaz:
https://doaj.org/article/17f58c3c082c4681a072d3458b175a73
Autor:
Eun Woo Kim, Benjamin U. Phillips, Christopher J. Heath, So Yeon Cho, Hyunjeong Kim, Jemeen Sreedharan, Ho-Taek Song, Jong Eun Lee, Timothy J. Bussey, Chul Hoon Kim, Eosu Kim, Lisa M. Saksida
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Reliable and reproducible assessment of animal learning and behavior is a central aim of basic and translational neuroscience research. Recent developments in automated operant chamber technology have led to the possibility of universal stan
Externí odkaz:
https://doaj.org/article/043513ee44e341bca0a70b93ab0796c9
Autor:
Christopher J. Heath, Claire O'Callaghan, Sarah L. Mason, Benjamin U. Phillips, Lisa M. Saksida, Trevor W. Robbins, Roger A. Barker, Timothy J. Bussey, Barbara J. Sahakian
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Apathy is pervasive across many neuropsychiatric disorders but is poorly characterized mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has been the lack of validated assessment tools to facilitate translation o
Externí odkaz:
https://doaj.org/article/ae37506d2123462dbd8a8a78b1519506
Autor:
Pedro Bekinschtein, Brianne A. Kent, Charlotte A. Oomen, Gregory D. Clemenson, Fred H. Gage, Lisa M. Saksida, Timothy J. Bussey
Publikováno v:
Cell Reports, Vol 5, Iss 3, Pp 759-768 (2013)
Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been refe
Externí odkaz:
https://doaj.org/article/dab561d8cc114d0b967af39d0415710c
Autor:
Pedro Bekinschtein, Cecilia P. Kramar, Olivia R. Ghosh-Swaby, Amy C. Reichelt, Lisa M. Saksida, Brianne A. Kent, Timothy J. Bussey, Paul A. S. Sheppard
Publikováno v:
Brain and Mind Institute Researchers' Publications
Keeping similar memories distinct from one another is a critical cognitive process without which we would have difficulty functioning in everyday life. Memories are thought to be kept distinct through the computational mechanism of pattern separation
Autor:
Stephanie Tullo, Aline S Miranda, Esther del Cid-Pellitero, Mei Peng Lim, Daniel Gallino, Anoosha Attaran, Raihaan Patel, Vladislav Novikov, Megan Park, Flavio H. Beraldo, Wen Luo, Irina Shlaifer, Thomas M. Durcan, Timothy J. Bussey, Lisa M. Saksida, Edward A. Fon, Vania F. Prado, Marco A.M. Prado, M. Mallar Chakravarty
There is significant evidence suggesting aggregated misfolded alpha-synuclein, a major component of Lewy bodies, propagates in a prion-like manner contributing to disease progression in Parkinson’s disease (PD) and other synucleinopathies. Animal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1551978d46642e96305cc28592344d79
https://doi.org/10.1101/2022.10.12.511820
https://doi.org/10.1101/2022.10.12.511820