Zobrazeno 1 - 10
of 324
pro vyhledávání: '"Timothy J. Bussey"'
Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer’s model mice
Autor:
So Yeon Cho, Eun Woo Kim, Soo Jin Park, Benjamin U. Phillips, Jihyeon Jeong, Hyunjeong Kim, Christopher J. Heath, Daehwan Kim, Yurim Jang, Laura López-Cruz, Lisa M. Saksida, Timothy J. Bussey, Do Yup Lee, Eosu Kim
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Metformin, a primary anti-diabetic medication, has been anticipated to provide benefits for Alzheimer’s disease (AD), also known as “type 3 diabetes”. Nevertheless, some studies have demonstrated that metformin may trigger AD pathology
Externí odkaz:
https://doaj.org/article/fb57a506ec6e4434861058289b715df9
Autor:
Sara Memar, Eric Jiang, Vania F. Prado, Lisa M. Saksida, Timothy J. Bussey, Marco A. M. Prado
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Open access to rodent cognitive data has lagged behind the rapid generation of large open-access datasets in other areas of neuroscience, such as neuroimaging and genomics. One contributing factor has been the absence of uniform standardizat
Externí odkaz:
https://doaj.org/article/1935e4365c724f179b5f09c6b0cbce55
Autor:
Miguel Skirzewski, Oren Princz-Lebel, Liliana German-Castelan, Alycia M. Crooks, Gerard Kyungwook Kim, Sophie Henke Tarnow, Amy Reichelt, Sara Memar, Daniel Palmer, Yulong Li, R. Jane Rylett, Lisa M. Saksida, Vania F. Prado, Marco A. M. Prado, Timothy J. Bussey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Nucleus accumbens cholinergic interneurons release acetylcholine and glutamate. Here, authors show that acetylcholine, rather than glutamate, is predominantly involved in updating dopamine dynamics mediating Pavlovian approach behaviours.
Externí odkaz:
https://doaj.org/article/f4d1dc4e75374f81957db4a31c2850f0
Autor:
Amy C. Reichelt, Claire A. Lemieux, Oren Princz-Lebel, Ashmita Singh, Timothy J. Bussey, Lisa M. Saksida
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Emergent evidence demonstrates that excessive consumption of high fat and high sugar (HFHS) diets has negative consequences on hippocampal and prefrontal cortex (PFC) function. Moreover, the delayed maturation of the PFC including the late d
Externí odkaz:
https://doaj.org/article/d825032133824eaea89aa5923ee80632
Autor:
Kayla M Ferko, Anna Blumenthal, Chris B Martin, Daria Proklova, Alexander N Minos, Lisa M Saksida, Timothy J Bussey, Ali R Khan, Stefan Köhler
Publikováno v:
eLife, Vol 11 (2022)
Vision neuroscience has made great strides in understanding the hierarchical organization of object representations along the ventral visual stream (VVS). How VVS representations capture fine-grained visual similarities between objects that observers
Externí odkaz:
https://doaj.org/article/1bdad062c5e94aaeb548a559f2ba2ca7
Autor:
Jisoo Lim, Eosu Kim, Hyun Jong Noh, Shinwon Kang, Benjamin U. Phillips, Dong Goo Kim, Timothy J. Bussey, Lisa Saksida, Christopher J. Heath, Chul Hoon Kim
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Genetic and pharmacological manipulations targeting metabotropic glutamate receptor 5 (mGluR5) affect performance in behavioural paradigms that depend on cognitive flexibility. Many of these studies involved exposing mice to highly stressful
Externí odkaz:
https://doaj.org/article/17f58c3c082c4681a072d3458b175a73
Autor:
Flavio H Beraldo, Daniel Palmer, Sara Memar, David I Wasserman, Wai-Jane V Lee, Shuai Liang, Samantha D Creighton, Benjamin Kolisnyk, Matthew F Cowan, Justin Mels, Talal S Masood, Chris Fodor, Mohammed A Al-Onaizi, Robert Bartha, Tom Gee, Lisa M Saksida, Timothy J Bussey, Stephen S Strother, Vania F Prado, Boyer D Winters, Marco AM Prado
Publikováno v:
eLife, Vol 8 (2019)
Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the availability of tools to share and disseminate data is scarce.
Externí odkaz:
https://doaj.org/article/eb34ca1f433b461497974bd568a6446d
Autor:
Eun Woo Kim, Benjamin U. Phillips, Christopher J. Heath, So Yeon Cho, Hyunjeong Kim, Jemeen Sreedharan, Ho-Taek Song, Jong Eun Lee, Timothy J. Bussey, Chul Hoon Kim, Eosu Kim, Lisa M. Saksida
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Reliable and reproducible assessment of animal learning and behavior is a central aim of basic and translational neuroscience research. Recent developments in automated operant chamber technology have led to the possibility of universal stan
Externí odkaz:
https://doaj.org/article/043513ee44e341bca0a70b93ab0796c9
Autor:
Christopher J. Heath, Claire O'Callaghan, Sarah L. Mason, Benjamin U. Phillips, Lisa M. Saksida, Trevor W. Robbins, Roger A. Barker, Timothy J. Bussey, Barbara J. Sahakian
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Apathy is pervasive across many neuropsychiatric disorders but is poorly characterized mechanistically, so targeted therapeutic interventions remain elusive. A key impediment has been the lack of validated assessment tools to facilitate translation o
Externí odkaz:
https://doaj.org/article/ae37506d2123462dbd8a8a78b1519506
Autor:
Pedro Bekinschtein, Cecilia P. Kramar, Olivia R. Ghosh-Swaby, Amy C. Reichelt, Lisa M. Saksida, Brianne A. Kent, Timothy J. Bussey, Paul A. S. Sheppard
Publikováno v:
Brain and Mind Institute Researchers' Publications
Keeping similar memories distinct from one another is a critical cognitive process without which we would have difficulty functioning in everyday life. Memories are thought to be kept distinct through the computational mechanism of pattern separation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5768f9df1c6fd78169e3c460fed982ad
https://doi.org/10.1038/s41596-021-00627-w
https://doi.org/10.1038/s41596-021-00627-w