Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Timothy J. Hartingh"'
Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease
Autor:
Rajini R. Mudhasani, Joseph W. Golden, Gregory C. Adam, Timothy J. Hartingh, Krishna P. Kota, David Ordonez, Corey R. Quackenbush, Julie P. Tran, Curtis Cline, Janice A. Williams, Xiankun Zeng, David B. Olsen, Linda A. Lieberman, Christopher Boyce, Anthony Ginnetti, J. Matthew Meinig, Rekha G. Panchal, Eric M. Mucker
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTAlthough smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak. While medical countermeasures (MCMs) previously approved by the Food
Externí odkaz:
https://doaj.org/article/53df8f67d29d4344baea9e9e6311d3a1
Autor:
Mark E. Layton, Jeffrey C. Kern, Timothy J. Hartingh, William D. Shipe, Izzat Raheem, Monika Kandebo, Robert P. Hayes, Sarah Huszar, Donnie Eddins, Bennett Ma, Joy Fuerst, Gordon K. Wollenberg, Jing Li, Jeff Fritzen, Georgia B. McGaughey, Jason M. Uslaner, Sean M. Smith, Paul J. Coleman, Christopher D. Cox
Publikováno v:
Journal of Medicinal Chemistry. 66:1157-1171
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34d1b1b6ca3f79f9d512404321891d5
https://doi.org/10.1021/acs.jmedchem.2c01521
https://doi.org/10.1021/acs.jmedchem.2c01521
Autor:
Jay A. Grobler, Abbas Walji, Paul J. Coleman, Min Xu, Timothy J. Hartingh, Natasa Pajkovic, John T. Sisko, David A. Powell, John M. Sanders, Michael D. Miller, Mark Embrey, Rada Vanessa L, Keith P. Moore, Daniel J. Klein, Nguyen Natalie, Izzat T. Raheem, Dubost David C, Guillaume Barbe, Louis-Charles Campeau, Daria J. Hazuda, John S. Wai, Thomas G. Steele, John D. Schreier, Jamie M. McCabe Dunn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2038-2046
HIV integrase strand transfer inhibitors (InSTIs) represent an important class of antiviral therapeutics with proven efficacy and excellent tolerability for the treatment of HIV infections. In 2007, Raltegravir became the first marketed strand transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3afda9a20f9b604f336f17e0d16627b
https://doi.org/10.1016/j.bmcl.2017.02.039
https://doi.org/10.1016/j.bmcl.2017.02.039
Autor:
Michael J. Kelly, Marlene A. Jacobson, Kerry L. Fillgrove, Alexander J. Reif, Ken Arrington, Robert M. Garbaccio, Kevin J. Rodzinak, Cheng Wang, Timothy J. Hartingh, Brian C. Magliaro, Sarah L. Huszar, Yuhsin Kuo, Cuyue Tang, Jason M. Uslaner, Vadim Y. Dudkin, Julie A. O'Brien, Mark E. Layton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1260-1264
Optimization of a benzimidazolone template for potency and physical properties revealed 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as a key template on which to develop a new series of mGlu2 positive allosteric modulators (PAMs). Systematic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8abce83ed7482841fbf9df1f25b2368
https://doi.org/10.1016/j.bmcl.2016.01.021
https://doi.org/10.1016/j.bmcl.2016.01.021
Autor:
Carrie Wolffe, Mark E. Fraley, Alexander Mccampbell, Rebecca B. White, Rena Zhang, John Majercak, Mary J. Savage, William J. Ray, Sang Jin Na, George D. Hartman, Shaei Y. Huang, Timothy J. Hartingh, Antonella Converso, Robert M. Garbaccio, Yuanjiang Yu, Suzie Yeh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2737-2740
Elevated plasma homocysteine (Hcy) levels are an independent risk factor for the onset and progression of Alzheimer's disease. Reduction of Hcy to normal levels therefore presents a new approach for disease modification. Hcy is produced by the cytoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8aa1f4f564027151b5c9e0f8c1f0175
https://doi.org/10.1016/j.bmcl.2014.04.034
https://doi.org/10.1016/j.bmcl.2014.04.034
Autor:
Marc Abrams, Laura Sepp-Lorenzino, Steve Stirdivant, Joan Zugay-Murphy, Keith W. Rickert, Xianzhi Mao, Stephen C. Beck, Mark E. Fraley, Robert M. Garbaccio, Rob Lobell, Youwei Yan, Bob Drakas, Paul Zuck, Sylvie Jezequel-Sur, Kelly Hamilton, Timothy J. Hartingh, Constantine Kreatsoulas, Edward S. Tasber, Sanjeev Munshi, Antonella Converso, Eileen S. Walsh, George D. Hartman, Carolyn A. Buser, Weikang Tao, V V Sardana
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1240-1244
A high throughput screening campaign was designed to identify allosteric inhibitors of Chk1 kinase by testing compounds at high concentration. Activity was then observed at K(m) for ATP and at near-physiological concentrations of ATP. This strategy l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a164d70b45a247a3957cdbd7608b23b
https://doi.org/10.1016/j.bmcl.2008.12.076
https://doi.org/10.1016/j.bmcl.2008.12.076
Autor:
Izzat T. Raheem, Abbas M. Walji, Daniel Klein, John M. Sanders, David A. Powell, Pravien Abeywickrema, Guillaume Barbe, Amrith Bennet, Karla Childers, Melodie Christensen, Sophie−Dorothee Clas, David Dubost, Mark Embrey, Jay Grobler, Michael J. Hafey, Timothy J. Hartingh, Daria J. Hazuda, Jeffrey T. Kuethe, Jamie McCabe Dunn, Michael D. Miller, Keith P. Moore, Andrew Nolting, Natasa Pajkovic, Sangita Patel, Zuihui Peng, Vanessa Rada, Paul Rearden, John D. Schreier, John Sisko, Thomas G. Steele, Jean-François Truchon, John Wai, Min Xu, Paul J. Coleman
Publikováno v:
Journal of Medicinal Chemistry. 59:486-486
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d53c21b2e9fa9a0d92172bf87ab40930
https://doi.org/10.1021/acs.jmedchem.5b01957
https://doi.org/10.1021/acs.jmedchem.5b01957
Autor:
Izzat T. Raheem, Abbas M. Walji, Daniel Klein, John M. Sanders, David A. Powell, Pravien Abeywickrema, Guillaume Barbe, Amrith Bennet, Sophie−Dorothee Clas, David Dubost, Mark Embrey, Jay Grobler, MichaelJ. Hafey, Timothy J. Hartingh, Daria J. Hazuda, Michael D. Miller, KeithP. Moore, Natasa Pajkovic, Sangita Patel, Vanessa Rada
Publikováno v:
Journal of Medicinal Chemistry; Oct2015, Vol. 58 Issue 20, p8154-8165, 12p