Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Timothy J de Wet"'
Autor:
Sophia Gessner, Zela Alexandria-Mae Martin, Michael A Reiche, Joana A Santos, Ryan Dinkele, Atondaho Ramudzuli, Neeraj Dhar, Timothy J de Wet, Saber Anoosheh, Dirk M Lang, Jesse Aaron, Teng-Leong Chew, Jennifer Herrmann, Rolf Müller, John D McKinney, Roger Woodgate, Valerie Mizrahi, Česlovas Venclovas, Meindert H Lamers, Digby F Warner
Publikováno v:
eLife, Vol 12 (2023)
A DNA damage-inducible mutagenic gene cassette has been implicated in the emergence of drug resistance in Mycobacterium tuberculosis during anti-tuberculosis (TB) chemotherapy. However, the molecular composition and operation of the encoded ‘mycoba
Externí odkaz:
https://doaj.org/article/9340d5204dad4cac96d701c78d904d63
Publikováno v:
eLife, Vol 9 (2020)
Mycobacterium tuberculosis possesses a large number of genes of unknown or predicted function, undermining fundamental understanding of pathogenicity and drug susceptibility. To address this challenge, we developed a high-throughput functional genomi
Externí odkaz:
https://doaj.org/article/5dd1bf85b54e4219b42f6ff28fdc13c9
Autor:
David A. Barr, Charlotte Schutz, Avuyonke Balfour, Muki Shey, Mireille Kamariza, Carolyn R. Bertozzi, Timothy J. de Wet, Ryan Dinkele, Amy Ward, Kathryn A. Haigh, Jean-Paul Kanyik, Valerie Mizrahi, Mark P. Nicol, Robert J. Wilkinson, David G. Lalloo, Digby F. Warner, Graeme Meintjes, Gerry Davies
Publikováno v:
EBioMedicine, Vol 78, Iss , Pp 103949- (2022)
Summary: Background: Despite being highly prevalent in hospitalised patients with severe HIV-associated tuberculosis (TB) and sepsis, little is known about the mycobacteriology of Mycobacterium tuberculosis bloodstream infection (MTBBSI). We develope
Externí odkaz:
https://doaj.org/article/b23d542ff14a41e78eaf5d443a71e548
Autor:
Lloyd Tanner, Gabriel T. Mashabela, Charles C. Omollo, Timothy J. de Wet, Christopher J. Parkinson, Digby F. Warner, Richard K. Haynes, Lubbe Wiesner
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT The therapeutic repertoire for tuberculosis (TB) remains limited despite the existence of many TB drugs that are highly active in in vitro models and possess clinical utility. Underlying the lack of efficacy in vivo is the inability of TB dr
Externí odkaz:
https://doaj.org/article/55ee631add7144e2a9c75f600d8c779b
Autor:
Williams, Nandi Niemand Wolhuter, Lerato Ngakane, Timothy J. de Wet, Robin M. Warren, Monique J.
Publikováno v:
Microorganisms; Volume 11; Issue 6; Pages: 1573
A-type carrier (ATC) proteins are proposed to function in the biogenesis of Fe-S clusters, although their exact role remains controversial. The genome of Mycobacterium smegmatis encodes a single ATC protein, MSMEG_4272, which belongs to the HesB/YadR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::f39bf1e7354d0f209fe494280f06e834
Autor:
Roopam Dey, Stephen Roche, Jean-Pierre du Plessis, Henri Carrara, Vrettos B, Dilesh Chhiba, Robert Dachs, Timothy J. de Wet, Tamzyn Trevor
Publikováno v:
Journal of Shoulder and Elbow Surgery. 30:1503-1510
The success of the modified Latarjet procedure depends on proper sizing of the coracoid graft. There is no information available regarding the morphometric relationship between the glenoid cavity and the coracoid process for the South African populat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb5879144c4dfa90933b906e838ec45
https://doi.org/10.1016/j.jse.2020.09.039
https://doi.org/10.1016/j.jse.2020.09.039
Autor:
Terry Kipkorir, Gabriel T. Mashabela, Timothy J. de Wet, Anastasia Koch, Stephanie S. Dawes, Lubbe Wiesner, Valerie Mizrahi, Digby F. Warner
Publikováno v:
J Bacteriol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef285073e11a99e85d99ad24c4d54470
https://europepmc.org/articles/PMC8923193/
https://europepmc.org/articles/PMC8923193/
Autor:
David A. Barr, Charlotte Schutz, Avuyonke Balfour, Muki Shey, Mireille Kamariza, Carolyn R. Bertozzi, Timothy J. de Wet, Ryan Dinkele, Amy Ward, Kathryn A. Haigh, Jean-Paul Kanyik, Valerie Mizrahi, Mark P. Nicol, Robert J. Wilkinson, David G. Lalloo, Digby F. Warner, Graeme Meintjes, Gerry Davies
Publikováno v:
EBioMedicine. 78
BACKGROUND: Despite being highly prevalent in hospitalised patients with severe HIV-associated tuberculosis (TB) and sepsis, little is known about the mycobacteriology of Mycobacterium tuberculosis bloodstream infection (MTBBSI). We developed methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba5f8760cefdec9c6ec8c96b929b808
https://pubmed.ncbi.nlm.nih.gov/35325781
https://pubmed.ncbi.nlm.nih.gov/35325781
Autor:
Gert Marais, Linda Boloko, Deelan Doolabh, Sipho Dlamini, Marc Mendelson, Michael-John Roslee, Hannah Hussey, Ntobeko A B Ntusi, Aimee Lifson, Mary-Ann Davies, Nei-yuan Hsiao, Robert J. Wilkinson, Graeme Meintjes, Sean Wasserman, Nectarios Papavarnavas, Arash Iranzadeh, Timothy J de Wet, Francesca Little, Carolyn Williamson
BackgroundThe SARS-CoV-2 Beta variant, associated with immune escape and higher transmissibility, drove a more severe second COVID-19 wave in South Africa. Individual patient level characteristics and outcomes with the Beta variant are not well chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e227d7ac8f435fab71c02b7fc67dfda5
https://doi.org/10.1101/2021.11.04.21265916
https://doi.org/10.1101/2021.11.04.21265916
Autor:
Terry Kipkorir, Gabriel T. Mashabela, Timothy J. de Wet, Anastasia Koch, Stephanie S. Dawes, Lubbe Wiesner, Valerie Mizrahi, Digby F. Warner
Publikováno v:
Journal of Bacteriology
Alterations in cobalamin-dependent metabolism have marked the evolution of Mycobacterium tuberculosis into a human pathogen. However, the role(s) of cobalamin in mycobacterial physiology remain poorly understood.
Cobalamin is an essential cofact
Cobalamin is an essential cofact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f28b0b43dccb1b824c84661b2066683
https://doi.org/10.1128/jb.00620-20
https://doi.org/10.1128/jb.00620-20