Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Timothy J Seabrook"'
BackgroundIt is estimated that there are more than 7,000 rare diseases (RDs) worldwide, impacting the lives of approximately 400 million people and only 5% have an approved therapy. Facing special challenges, including patient scarceness, incomplete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b1e3afd36edeae82cb30deb5a091a53
https://doi.org/10.1101/2021.12.03.471055
https://doi.org/10.1101/2021.12.03.471055
Autor:
Marie José Frossard, Nicolas Martinier, Rosanna Pescini Gobert, Ursula Boschert, Corinne Brana, Timothy J. Seabrook
Publikováno v:
Neuropathology and Applied Neurobiology. 40:564-578
Aims Sphingosine-1-phosphate receptor (S1PR) modulating therapies are currently in the clinic or undergoing investigation for multiple sclerosis (MS) treatment. However, the expression of S1PRs is still unclear in the central nervous system under nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a518ab9b0485c139e62b3f59f342a286
https://doi.org/10.1111/nan.12048
https://doi.org/10.1111/nan.12048
Autor:
Liying Jiang, Ying Peng, Cynthia A. Lemere, Marcel Maier, Timothy J. Seabrook, Michael C. Carroll
Publikováno v:
Journal of Neuroscience. 28:6333-6341
Complement factor C3 is the central component of the complement system and a key inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated that inhibition of C3 by overexpression of soluble complement receptor-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf5192961a452366f2683d864b1f5f36
https://doi.org/10.1523/jneurosci.0829-08.2008
https://doi.org/10.1523/jneurosci.0829-08.2008
Publikováno v:
Current Alzheimer Research. 4:427-436
Active and passive Aβ immunotherapy in Alzheimers disease (AD)-like mouse models lowers cerebral amyloid- β protein (Aβ) levels, especially if given early in the disease process, and improves cognitive deficits. In 2002, a Phase IIa clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::642ddb982b79772ff6cde29f5c0a54ce
https://doi.org/10.2174/156720507781788800
https://doi.org/10.2174/156720507781788800
Autor:
Jeanne K. Bloom, Timothy J. Seabrook, Melitza Iglesias, Cynthia A. Lemere, Edward T. Spooner, Dominic M. Walsh
Publikováno v:
Neurobiology of Aging. 25:1141-1151
Amyloid beta (A beta) immunization of amyloid precursor protein (APP)-transgenic (tg) mice with human A beta induces humoral immunity, however, the immune response to endogenous rodent A beta is unknown. Fourteen-month J20 APP-tg mice and non-tg litt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f986ed4fb4b80e1c4d6232da0f8c351
https://doi.org/10.1016/j.neurobiolaging.2003.12.008
https://doi.org/10.1016/j.neurobiolaging.2003.12.008
Publikováno v:
Vaccine. 22:4075-4083
The cerebral accumulation of beta-amyloid (Abeta) is a pathological hallmark of Alzheimer's disease (AD). Abeta vaccination or anti-Abeta specific antibodies may be a possible therapeutic option for AD. Previously, we demonstrated variation in the hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad219f98411b302a1aaa24b41fb1940e
https://doi.org/10.1016/j.vaccine.2004.03.061
https://doi.org/10.1016/j.vaccine.2004.03.061
Autor:
Edward T. Spooner, Timothy J. Seabrook, Jeanne K. Bloom, Jodi F. Leverone, Chica Mori, Melitza Iglesias, Cynthia A. Lemere
Publikováno v:
Neurochemical Research. 28:1017-1027
Alzheimer's disease is the most prevalent form of dementia worldwide. Therapies are desperately needed to prevent and cure the disease. Mouse models of amyloid-β deposition [APP and PSAPP transgenic (tg) mice] have been useful in determining the rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ef452f589dfa44f7521e07e62cd5d78
https://doi.org/10.1023/a:1023203122036
https://doi.org/10.1023/a:1023203122036
Autor:
Bill Ristevski, Jiri Zamecnik, John B. Hay, Roy J. Shephard, Pang N. Shek, Timothy J Seabrook, Shawn G. Rhind
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 79:246-252
The lymphatic system has a critical role in the return of fluids, proteins, and cells to the circulatory system. However, the effects of stress, including exercise, on this system have not been adequately studied. We investigated the effect of a phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd1848b75f4a4df4646db48411ce7c56
https://doi.org/10.1139/y00-124
https://doi.org/10.1139/y00-124
Publikováno v:
Brain Research Protocols. 6:172-177
It is well documented that there is communication between the cerebral spinal fluid (CSF) and cervical lymphatics. Recently, it has been demonstrated that tumor necrosis factor alpha (TNF-alpha) introduced into the CSF appears in the cervical lymph.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c622abf7b8cfacfce163948c91af63
https://doi.org/10.1016/s1385-299x(00)00052-0
https://doi.org/10.1016/s1385-299x(00)00052-0
Autor:
Corinne, Brana, Marie José, Frossard, Rosanna, Pescini Gobert, Nicolas, Martinier, Ursula, Boschert, Timothy J, Seabrook
Publikováno v:
Neuropathology and applied neurobiology. 40(5)
Sphingosine-1-phosphate receptor (S1PR) modulating therapies are currently in the clinic or undergoing investigation for multiple sclerosis (MS) treatment. However, the expression of S1PRs is still unclear in the central nervous system under normal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a5e292b38d6837f9561a271be539d55
https://pubmed.ncbi.nlm.nih.gov/23551178
https://pubmed.ncbi.nlm.nih.gov/23551178