Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Timothy J Opperman"'
Autor:
Jamal Chauhan, Steven Cardinale, Lei Fang, Jing Huang, Steven M Kwasny, M Ross Pennington, Kelly Basi, Robert diTargiani, Benedict R Capacio, Alexander D MacKerell, Timothy J Opperman, Steven Fletcher, Erik P H de Leeuw
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164515 (2016)
Recently we described a novel di-benzene-pyrylium-indolene (BAS00127538) inhibitor of Lipid II. BAS00127538 (1-Methyl-2,4-diphenyl-6-((1E,3E)-3-(1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)pyryl-1-ium) tetrafluoroborate is the first small molecul
Externí odkaz:
https://doaj.org/article/3b20d0e6c31f4ac6bf0d0a03d1cf8c71
Autor:
Timothy J Opperman, Son T Nguyen
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Multi-drug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat infections caused by these organisms. A major component in the developme
Externí odkaz:
https://doaj.org/article/564b416639ef4639993c51c3dade2ee5
Autor:
Cecilia Gutierrez-Perez, Charles Puerner, Jane T. Jones, Sandeep Vellanki, Elisa M. Vesely, Mark A. Xatse, Andre F. C. Viera, Carissa P. Olsen, Keren O. Attiku, Steven Cardinale, Steven M. Kwasny, Narendran G-Dayanandan, Timothy J. Opperman, Robert A. Cramer
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Contemporary antifungal therapies utilized to treat filamentous fungal infections are inhibited by intrinsic and emerging drug resistance. Consequently, there is an urgent need to develop novel antifungal compounds that are effective against
Externí odkaz:
https://doaj.org/article/6c6f0dfdb29846f4968aadcda7933aa2
Autor:
Steven C. Cardinale, Erik de Leeuw, Steven Fletcher, Wenbo Yu, Jay Chauhan, Alexander D. MacKerell, Timothy J. Opperman
Publikováno v:
Drug Design, Development and Therapy. 14:567-574
Background The bacterial cell envelope is comprised of the cell membrane and the cell wall. The bacterial cell wall provides rigidity to the cell and protects the organism from potential harmful substances also. Cell wall biosynthesis is an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8bc532fa457d082cd47ecd4950f42e2
https://doi.org/10.2147/dddt.s226313
https://doi.org/10.2147/dddt.s226313
Autor:
Andrea J. Parsons, Sabrina I. Ophir, Thomas J. Gardner, Jailene Casado Paredes, Kathryn R. Stein, Steven M. Kwasny, Steven C. Cardinale, Matthew Torhan, Mark N. Prichard, Scott H. James, Kristina E. Atanasoff, Narendran G-Dayanandan, Terry L. Bowlin, Timothy J. Opperman, Domenico Tortorella
Publikováno v:
Antiviral Research. 209:105474
Human cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes latent asymptomatic infections in healthy individuals but can cause serious infections in immunocompromised people, resulting in increased risk of morbidity and mortality. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33efc4316f8c6a98fd65200109a1564e
https://doi.org/10.1016/j.antiviral.2022.105474
https://doi.org/10.1016/j.antiviral.2022.105474
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1849-1853
Lipid II is an essential precursor of bacterial cell wall biosynthesis and an attractive target for antibiotics. Lipid II is comprised of specialized lipid (bactoprenol) linked to a hydrophilic head group consisting of a peptidoglycan subunit (N-acet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324fc88dc03e261734d64417243c72fd
https://doi.org/10.1016/j.bmcl.2019.04.046
https://doi.org/10.1016/j.bmcl.2019.04.046
Autor:
Atousa Mehrani, Mynthia Cabrera, Kenneth C. Keiler, Michelle M. Butler, Steven M. Kwasny, Pooja Srinivas, Lucas R. Morin, Divya Hosangadi, John N. Alumasa, Jay S. Barbor, Steven C. Cardinale, Scott M. Stagg, Zachary D. Aron, Christine M. Dunham, Ann E. Jerse, Matthew C. Torhan, Timothy J. Opperman, Eric D. Hoffer, Terry L. Bowlin, Kristie L. Connolly
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411f83145a0e100fbdf1e585bbf3dfa6
https://doi.org/10.1038/s41467-021-22012-7
https://doi.org/10.1038/s41467-021-22012-7
Publikováno v:
Drug discovery today. 26(9)
The increasing prevalence of multidrug-resistant (MDR) bacterial infections has created a crucial need for new therapeutics that avoid or minimize existing resistance mechanisms. In this review, we describe the development of novel classes of small-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84f4c5a829015ecb4d8140706acacb4
https://pubmed.ncbi.nlm.nih.gov/33845218
https://pubmed.ncbi.nlm.nih.gov/33845218
Autor:
Divya Hosangadi, Lucas R. Morin, Kristie L. Connolly, Terry L. Bowlin, Michelle M. Butler, Christine M. Dunham, Atousa Mehrani, Zachary D. Aron, Jay S. Barbor, John N. Alumasa, Pooja Srinivas, Kenneth C. Keiler, Eric D. Hoffer, Mynthia Cabrera, Matthew C. Torhan, Scott M. Stagg, Steven M. Kwasny, Timothy J. Opperman, Ann E. Jerse, Steven C. Cardinale
The trans-translation pathway for rescuing stalled ribosomes is conserved and essential in bacterial pathogens but has no mammalian homolog, making it an ideal target for new antibiotics. We previously reported the discovery of a family of acylaminoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c60f516b4139e9bac172634fa60d14b
https://doi.org/10.1101/2020.06.04.132530
https://doi.org/10.1101/2020.06.04.132530
Autor:
Jay, Chauhan, Wenbo, Yu, Steven, Cardinale, Timothy J, Opperman, Alexander D, MacKerell, Steven, Fletcher, Erik Ph, de Leeuw
Publikováno v:
Drug Design, Development and Therapy
Background The bacterial cell envelope is comprised of the cell membrane and the cell wall. The bacterial cell wall provides rigidity to the cell and protects the organism from potential harmful substances also. Cell wall biosynthesis is an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cc728d05b7567fb04527d950ff2d36a
https://pubmed.ncbi.nlm.nih.gov/32103898
https://pubmed.ncbi.nlm.nih.gov/32103898