Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Timothy J Mohun"'
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235433 (2020)
ADP-ribosylhydrolase-like 1 (Adprhl1) is a pseudoenzyme expressed in the developing heart myocardium of all vertebrates. In the amphibian Xenopus laevis, knockdown of the two cardiac Adprhl1 protein species (40 and 23 kDa) causes failure of chamber o
Externí odkaz:
https://doaj.org/article/57e1bf1890cc41bfbb3253c815e78eb1
Autor:
Jean-François Le Garrec, Jorge N Domínguez, Audrey Desgrange, Kenzo D Ivanovitch, Etienne Raphaël, J Andrew Bangham, Miguel Torres, Enrico Coen, Timothy J Mohun, Sigolène M Meilhac
Publikováno v:
eLife, Vol 6 (2017)
How left-right patterning drives asymmetric morphogenesis is unclear. Here, we have quantified shape changes during mouse heart looping, from 3D reconstructions by HREM. In combination with cell labelling and computer simulations, we propose a novel
Externí odkaz:
https://doaj.org/article/4f3a99d7fac64740a1cd302a855eaa78
Autor:
Ross A Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J Ragan, James A West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C Kienesberger, Ryszard T Smolenski, Hillary K Siddall, John L Offer, Mihaela M Mocanu, Derek M Yelon, Jason R B Dyck, Jules L Griffin, Andrey Y Abramov, Alex P Gould, Timothy J Mohun
Publikováno v:
PLoS Biology, Vol 11, Iss 9, p e1001666 (2013)
Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, wh
Externí odkaz:
https://doaj.org/article/c94bc252bb4048fdb56691e64de2627d
Publikováno v:
Journal of anatomyREFERENCES. 240(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292daa944be773e760c3bc7c6f87cc07
https://pubmed.ncbi.nlm.nih.gov/34708411
https://pubmed.ncbi.nlm.nih.gov/34708411
Autor:
Yolanda Macías, Marcos C de Almeida, Justin T Tretter, Robert H Anderson, Diane E Spicer, Timothy J Mohun, Damián Sánchez-Quintana, Jerónimo Farré, Eduardo Back Sternick
Publikováno v:
EP Europace. 24:443-454
Aims The arrangement of the conduction axis is markedly different in various mammalian species. Knowledge of such variation may serve to question the validity of using animals as prospective models for design of systems for clinical use. Methods and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716143005f37721d3e608bf4a9deff20
https://doi.org/10.1093/europace/euab291
https://doi.org/10.1093/europace/euab291
Autor:
Rohit S. Loomba, Justin T. Tretter, Timothy J. Mohun, Robert H. Anderson, Scott Kramer, Diane E. Spicer
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 7, Iss 3, p 35 (2020)
Background: The vestibular atrial septal defect is an interatrial communication located in the antero-inferior portion of the atrial septum. Reflecting either inadequate muscularization of the vestibular spine and mesenchymal cap during development,
Externí odkaz:
https://doaj.org/article/e8cff2c3b68744e5a0c57da8c7431efd
Autor:
Amy-Leigh Johnson, Jürgen E. Schneider, Timothy J. Mohun, Trevor Williams, Shoumo Bhattacharya, Deborah J. Henderson, Helen M. Phillips, Simon D. Bamforth
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 7, Iss 3, p 27 (2020)
Congenital cardiovascular malformation is a common birth defect incorporating abnormalities of the outflow tract and aortic arch arteries, and mice deficient in the transcription factor AP-2α (Tcfap2a) present with complex defects affecting these st
Externí odkaz:
https://doaj.org/article/350e5470eb3f4e3491b1366b073b678a
Autor:
Ramada R. Khasawneh, Simon D. Bamforth, Helen M. Phillips, Timothy J. Mohun, Jürgen E. Schneider, Stéphane Zaffran, Heiko Peters, Ralf Kist, Rachel Queen, Rafiqul Hussain, Jonathan Coxhead
Publikováno v:
BMC Developmental Biology, Vol 21, Iss 1, Pp 1-20 (2021)
BMC Developmental Biology
BMC Developmental Biology, BioMed Central, 2021, 21 (1), pp.14. ⟨10.1186/s12861-021-00245-5⟩
BMC Developmental Biology, 2021, 21 (1), pp.14. ⟨10.1186/s12861-021-00245-5⟩
BMC Developmental Biology
BMC Developmental Biology, BioMed Central, 2021, 21 (1), pp.14. ⟨10.1186/s12861-021-00245-5⟩
BMC Developmental Biology, 2021, 21 (1), pp.14. ⟨10.1186/s12861-021-00245-5⟩
Background Successful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient for either gene display abno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c03a87f7d831ce7e331600e5caebbee
https://doaj.org/article/b7355328ecb548c9b658f6fd48c10d6d
https://doaj.org/article/b7355328ecb548c9b658f6fd48c10d6d
The mammalian heart, which is one of the first organs to form and function during embryogenesis, develops from a simple tube into a complex organ able to efficiently pump blood towards the rest of the body. The progressive growth of the compact myoca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710acbe494f6e5b144bc77588adfcc94
https://lirias.kuleuven.be/handle/20.500.12942/717577
https://lirias.kuleuven.be/handle/20.500.12942/717577
Autor:
Wolfgang Weninger, Jacqueline Katie White, Stefan H. Geyer, Fabrice Prin, Antonella Galli, Julia Rose, Timothy J. Mohun, Robert Wilson, Lukas F. Reissig, Barbara Maurer-Gesek, Catherine Tudor
Publikováno v:
Journal of Anatomy
Approximately one‐third of randomly produced knockout mouse lines produce homozygous offspring, which fail to survive the perinatal period. The majority of these die around or after embryonic day (E)14.5, presumably from cardiovascular insufficienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19492ca36f999ac2f957bc0c6c4d184b
https://doi.org/10.1111/joa.13536
https://doi.org/10.1111/joa.13536