Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Timothy J Jarome"'
Autor:
Taylor McFadden, Natasha Gaito, Isabella Carucci, Everett Fletchall, Kayla Farrell, Timothy J Jarome
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284286 (2023)
Obesity is a complex medical condition that is linked to various health complications such as infertility, stroke, and osteoarthritis. Understanding the neurobiology of obesity is crucial for responding to the etiology of this disease. The hypothalam
Externí odkaz:
https://doaj.org/article/c2e06b73304540fcbc27e2fb56bda1ee
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 8 (2015)
Gadd45-mediated DNA demethylation mechanisms have been implicated in the process of memory formation. However, the transcriptional mechanisms involved in the regulation of Gadd45 gene expression during memory formation remain unexplored. NF-kB (nucle
Externí odkaz:
https://doaj.org/article/e8f38ce6da6a42c4b7e86b32a1065564
Autor:
Timothy J Jarome, Fred J Helmstetter
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 7 (2014)
Long-term memory (LTM) formation requires transient changes in the activity of intracellular signaling cascades that are thought to regulate new gene transcription and de novo protein synthesis in the brain. Consistent with this, protein synthesis in
Externí odkaz:
https://doaj.org/article/010ea8fc42a04df0b5dd98182be4f725
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 7 (2013)
The cellular mechanisms supporting plasticity during memory consolidation have been a subject of considerable interest. De novo protein and mRNA synthesis in several brain areas are critical, and more recently protein degradation, mediated by the ubi
Externí odkaz:
https://doaj.org/article/1153d69ebb6a4e28822a9d956b3be1a0
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 7 (2013)
CaMKII and Protein Kinase A (PKA) are thought to be critical for synaptic plasticity and memory formation through their regulation of protein synthesis. Consistent with this, numerous studies have reported that CaMKII, PKA and protein synthesis are c
Externí odkaz:
https://doaj.org/article/6bcc6acfb462409880e459aa27e826de
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24349 (2011)
Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity. However, its role in memory formation in the amygdala, a site critical for the formation of fear memories, currently remains
Externí odkaz:
https://doaj.org/article/03e78f20d63946e699dc6037aa7c59d5
Publikováno v:
Learning & Memory. 30:70-73
Strong evidence has implicated proteasome-mediated protein degradation in the memory consolidation process. However, due to the use of pharmacological approaches, the cell type specificity of this remains unknown. Here, we used neuron-specific and no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d6a2beadb6924140e821084366936a
https://doi.org/10.1101/lm.053716.122
https://doi.org/10.1101/lm.053716.122
Publikováno v:
Nutritional neuroscience.
Previous work has shown that exposure to a high fat diet dysregulates the protein degradation process in the hypothalamus of male rodents. However, whether this occurs in a sex-independent manner is unknown. The objective of this study was to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b4216713cbfd573ea53ebbe1c4b3dd
https://pubmed.ncbi.nlm.nih.gov/35282800
https://pubmed.ncbi.nlm.nih.gov/35282800
Publikováno v:
Learning & Memory. 29:256-264
Reports of sex differences in the neurobiology of memory formation are becoming more prevalent. Despite this, much remains unknown about the role of sex in this process. We previously reported the first evidence of a novel epigenetic role for proteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4948fdca63c5acc61025807372073f12
https://doi.org/10.1101/lm.053498.121
https://doi.org/10.1101/lm.053498.121
Autor:
Kayla Farrell, Madeline Musaus, Aubrey Auerbach, Shaghayegh Navabpour, W. Keith Ray, Richard F. Helm, Timothy J. Jarome
Publikováno v:
Molecular Psychiatry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbdba100ea13032537c17b9a5341f7cf
https://doi.org/10.1038/s41380-023-02112-0
https://doi.org/10.1038/s41380-023-02112-0