Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Timothy J Hearn"'
Autor:
François Kroll, Gareth T Powell, Marcus Ghosh, Gaia Gestri, Paride Antinucci, Timothy J Hearn, Hande Tunbak, Sumi Lim, Harvey W Dennis, Joseph M Fernandez, David Whitmore, Elena Dreosti, Stephen W Wilson, Ellen J Hoffman, Jason Rihel
Publikováno v:
eLife, Vol 10 (2021)
Hundreds of human genes are associated with neurological diseases, but translation into tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to investigate genetic contributions to neurological diseases. However, curre
Externí odkaz:
https://doaj.org/article/25c5de04b6ba4affaa9daf01476b7bbd
Autor:
Laurent Mombaerts, Alberto Carignano, Fiona C Robertson, Timothy J Hearn, Jin Junyang, David Hayden, Zoe Rutterford, Carlos T Hotta, Katherine E Hubbard, Marti Ruiz C Maria, Ye Yuan, Matthew A Hannah, Jorge Goncalves, Alex A R Webb
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006674 (2019)
The circadian oscillator, an internal time-keeping device found in most organisms, enables timely regulation of daily biological activities by maintaining synchrony with the external environment. The mechanistic basis underlying the adjustment of cir
Externí odkaz:
https://doaj.org/article/19c9bf8d43ae49adab43eb86c2a2c240
Autor:
Timothy J Hearn, Stephen W. Wilson, Elena Dreosti, Joseph M Fernandez, Sumi Lim, Marcus Ghosh, Jason Rihel, Gaia Gestri, Paride Antinucci, David Whitmore, Ellen J. Hoffman, François Kroll, Gareth T. Powell, Harvey W Dennis, Hande Tunbak
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Hundreds of human genes are associated with neurological diseases, but translation into tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to investigate genetic contributions to neurological diseases. However, curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb20cc8eabbcc21f5474f2f2f603b514
https://doi.org/10.7554/elife.59683
https://doi.org/10.7554/elife.59683
Autor:
Marcus Ghosh, Elena Dreosti, Stephen W. Wilson, Timothy J Hearn, Paride Antinucci, Sumi Lim, Jason Rihel, Gareth T. Powell, Harvey W Dennis, Ellen J. Hoffman, David Whitmore, François Kroll, Hande Tunbak, Joseph M Fernandez, Gaia Gestri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb3ec0c4e2a8949c8135a89d069735a5
https://doi.org/10.7554/elife.59683.sa2
https://doi.org/10.7554/elife.59683.sa2
Autor:
Timothy J Hearn, Basimah T Malik
The role of the circadian clock is becoming apparent in many aspects of human health and disease. Large scale GWAS studies have delivered high numbers of genetic markers for chronotype, which can be used to find links to Mendelian disorders. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba955b3763b23973f6380207bda7de4d
Autor:
Lydia M Seed, Timothy J. Hearn
Diurnal oscillations in human cardiac electrophysiology are thought to be under the control of the endogenous circadian clock. The incidence of arrhythmic events in patients with Long QT syndrome (LQTS) varies diurnally. The diurnal variation in QT i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1585c881debbb30fba67834850930e
https://doi.org/10.1101/2020.07.23.20160978
https://doi.org/10.1101/2020.07.23.20160978
Autor:
François Kroll, Gareth T Powell, Marcus Ghosh, Paride Antinucci, Timothy J Hearn, Hande Tunbak, Sumi Lim, Harvey W Dennis, Joseph M Fernandez, David Whitmore, Elena Dreosti, Stephen W Wilson, Ellen J Hoffman, Jason Rihel
Data and code for preprint Kroll, F. et al.2020. A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. https://www.biorxiv.org/content/10.1101/2020.06.04.133462v3 You can also navigate the files here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a7c0073096c61be7c92b9bc6fe987c7
Autor:
Sumi Lim, Jason Rihel, Stephen W. Wilson, Ellen J. Hoffman, Elena Dreosti, Marcus Ghosh, David Whitmore, Hande Tunbak, Joseph M Fernandez, Timothy J Hearn, François Kroll, Gareth T. Powell, Harvey W Dennis, Paride Antinucci
Hundreds of human genes are associated with neurological diseases, but translation into tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to investigate genetic contributions to neurological diseases. However, curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2d7eab0ff311286d2638075098b3120
https://doi.org/10.1101/2020.06.04.133462
https://doi.org/10.1101/2020.06.04.133462
Autor:
Alex A. R. Webb, Timothy J. Hearn
Publikováno v:
F1000Research
Circadian clocks have evolved to synchronise an organism’s physiology with the environmental rhythms driven by the Earth’s rotation on its axis. Over the past two decades, many of the genetic components of the Arabidopsis thaliana circadian oscil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905a2f8cb32635fb471f5a625057ca02
Publikováno v:
Journal of Theoretical Biology. 457:137-151
Circadian entrainment is the process by which internal circadian oscillators staying in synchronization with the local environmental rhythms. Circadian clocks are entrained by adjusting phase and period in response to environmental and metabolic sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c4113c8d5b49ed8e7f7f858c203897
https://doi.org/10.1016/j.jtbi.2018.08.020
https://doi.org/10.1016/j.jtbi.2018.08.020