Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Timothy J Collier"'
Autor:
Natosha M. Mercado, Carlye Szarowicz, Jennifer A. Stancati, Caryl E. Sortwell, Samuel A. Boezwinkle, Timothy J. Collier, Margaret E. Caulfield, Kathy Steece-Collier
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract The rs6265 single nucleotide polymorphism (SNP) in the gene for brain-derived neurotrophic factor is a common variant that alters therapeutic outcomes for individuals with Parkinson’s disease (PD). We previously investigated the effects of
Externí odkaz:
https://doaj.org/article/04243b627f4647388bacb505772446ee
Autor:
Margaret E. Caulfield, Molly J. Vander Werp, Jennifer A. Stancati, Timothy J. Collier, Caryl E. Sortwell, Ivette M. Sandoval, Fredric P. Manfredsson, Kathy Steece-Collier
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106111- (2023)
In the past 25 years, the prevalence of Parkinson's disease (PD) has nearly doubled. Age remains the primary risk factor for PD and as the global aging population increases this trend is predicted to continue. Even when treated with levodopa, the gol
Externí odkaz:
https://doaj.org/article/0a32cba2dcf34119b5bce4aa489fc00e
Autor:
Emily J. Jaehne, Jessica N. Kent, Emily J. Antolasic, Bradley J. Wright, Jereme G. Spiers, Kerstin C. Creutzberg, Federico De Rosa, Marco A. Riva, Caryl E. Sortwell, Timothy J. Collier, Maarten van den Buuse
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The common brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with reduced activity-dependent BDNF release and increased risk for anxiety disorders and PTSD. Here we behaviorally phenotyped a novel Val66Met rat mode
Externí odkaz:
https://doaj.org/article/b534cf45a6ff4b8fb6cb5a717a77117e
Autor:
Tracy A. Cole, Hien Zhao, Timothy J. Collier, Ivette Sandoval, Caryl E. Sortwell, Kathy Steece-Collier, Brian F. Daley, Alix Booms, Jack Lipton, Mackenzie Welch, Melissa Berman, Luke Jandreski, Danielle Graham, Andreas Weihofen, Stephanie Celano, Emily Schulz, Allyson Cole-Strauss, Esteban Luna, Duc Quach, Apoorva Mohan, C. Frank Bennett, Eric E. Swayze, Holly B. Kordasiewicz, Kelvin C. Luk, Katrina L. Paumier
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Parkinson’s disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single nucleotide polymorphisms in the SNCA gene, encoding α-synuclein (aSyn) protein, either cause or
Externí odkaz:
https://doaj.org/article/d06ea6f3c76f4b97a20be199ac938389
Autor:
João Pedro Ferreira, John G.F. Cleland, Nicolas Girerd, Pierpaolo Pellicori, Mark R. Hazebroek, Job Verdonschot, Timothy J. Collier, Johannes Petutschnigg, Andrew L. Clark, Jan A. Staessen, Stephane Heymans, Patrick Rossignol, Faiez Zannad
Publikováno v:
American Journal of Cardiology, 191, 39-42. Excerpta Medica, Elsevier Science
The QRS duration can be easily obtained from a 12-lead electrocardiogram. Increased QRS duration reflects greater ventricular activation times and often ventricular dyssyn-chrony. Dyssynchrony causes an impairment of the global cardiac function and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915e9fba5ee37986bad8800f0c496eb7
https://doi.org/10.1016/j.amjcard.2022.12.016
https://doi.org/10.1016/j.amjcard.2022.12.016
Autor:
Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105175- (2021)
Prevalent in approximately 20% of the worldwide human population, the rs6265 (also called ‘Val66Met’) single nucleotide polymorphism (SNP) in the gene for brain-derived neurotrophic factor (BDNF) is a common genetic variant that can alter therape
Externí odkaz:
https://doaj.org/article/db10f0cf24c5467a89a08574d6b5d9db
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Autor:
Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson’s disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. However, d
Externí odkaz:
https://doaj.org/article/78b82214e6ad41e9bc7e34dc3be1cf71
Autor:
Timothy J. Collier, Kinshuk R. Srivastava, Craig Justman, Tom Grammatopoulous, Birgit Hutter-Paier, Manuela Prokesch, Daniel Havas, Jean-Christophe Rochet, Fang Liu, Kevin Jock, Patrícia de Oliveira, Georgia L. Stirtz, Ulf Dettmer, Caryl E. Sortwell, Mel B. Feany, Peter Lansbury, Lisa Lapidus, Katrina L. Paumier
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 191-204 (2017)
The pathology of Parkinson's disease and other synucleinopathies is characterized by the formation of intracellular inclusions comprised primarily of misfolded, fibrillar α-synuclein (α-syn). One strategy to slow disease progression is to prevent t
Externí odkaz:
https://doaj.org/article/416c1a4af85442e1a86a6af150c46583
Autor:
Joseph R. Patterson, Megan F. Duffy, Christopher J. Kemp, Jacob W. Howe, Timothy J. Collier, Anna C. Stoll, Kathryn M. Miller, Pooja Patel, Nathan Levine, Darren J. Moore, Kelvin C. Luk, Sheila M. Fleming, Nicholas M. Kanaan, Katrina L. Paumier, Omar M.A. El-Agnaf, Caryl E. Sortwell
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104525- (2019)
Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system and motor deficits can be useful tools for Parkinson's disease (PD) research. The preformed
Externí odkaz:
https://doaj.org/article/758f84c3154542e3af56b5659a3f143d
Autor:
Stuart J. Pocock, João Pedro Ferreira, Timothy J. Collier, Christiane E. Angermann, Jan Biegus, Sean P. Collins, Mikhail Kosiborod, Michael E. Nassif, Piotr Ponikowski, Mitchell A. Psotka, John R. Teerlink, Jasper Tromp, John Gregson, Jonathan P. Blatchford, Cordula Zeller, Adriaan A. Voors
Publikováno v:
European Journal of Heart Failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dae2ecfd6234911e2d82b54a5cebbf46
https://doi.org/10.1002/ejhf.2853
https://doi.org/10.1002/ejhf.2853