Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Timothy J C Tan"'
Autor:
Joel Rivera-Cardona, Neeha Kakuturu, Elizabeth F Rowland, Qi Wen Teo, Elizabeth A Thayer, Timothy J C Tan, Jiayi Sun, Collin Kieffer, Nicholas C Wu, Christopher B Brooke
Publikováno v:
PLoS Pathogens, Vol 20, Iss 12, p e1012727 (2024)
The circulation of seasonal influenza A viruses (IAVs) in humans relies on effective evasion and subversion of the host immune response. While the evolution of seasonal H1N1 and H3N2 viruses to avoid humoral immunity is well characterized, relatively
Externí odkaz:
https://doaj.org/article/1326bbc513284d0b889cfcf7c8427706
Autor:
Weiwen Liang, Timothy J C Tan, Yiquan Wang, Huibin Lv, Yuanxin Sun, Roberto Bruzzone, Chris K P Mok, Nicholas C Wu
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010875 (2022)
Egg-adaptive mutations in influenza hemagglutinin (HA) often emerge during the production of egg-based seasonal influenza vaccines, which contribute to the largest share in the global influenza vaccine market. While some egg-adaptive mutations have m
Externí odkaz:
https://doaj.org/article/e80291d5971a405e81800a812414806f
Autor:
Ruipeng Lei, Weiwen Liang, Wenhao O. Ouyang, Andrea Hernandez Garcia, Chika Kikuchi, Shengyang Wang, Ryan McBride, Timothy J. C. Tan, Yuanxin Sun, Chunke Chen, Claire S. Graham, Lucia A. Rodriguez, Ivana R. Shen, Danbi Choi, Roberto Bruzzone, James C. Paulson, Satish K. Nair, Chris K. P. Mok, Nicholas C. Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe that mutations G186D and D190N in the hemagglutinin receptor-binding site have coevo
Externí odkaz:
https://doaj.org/article/c60b17324d1f49b88d25cffb3c14c7d7
Autor:
Ruipeng Lei, Enya Qing, Abby Odle, Meng Yuan, Chaminda D. Gunawardene, Timothy J. C. Tan, Natalie So, Wenhao O. Ouyang, Ian A. Wilson, Tom Gallagher, Stanley Perlman, Nicholas C. Wu, Lok-Yin Roy Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence determinants at the fusion peptide and its adjacent regions for
Externí odkaz:
https://doaj.org/article/be4e9943c217458b99039b79fd1789b0
Autor:
Timothy J. C. Tan, Zongjun Mou, Ruipeng Lei, Wenhao O. Ouyang, Meng Yuan, Ge Song, Raiees Andrabi, Ian A. Wilson, Collin Kieffer, Xinghong Dai, Kenneth A. Matreyek, Nicholas C. Wu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to stabilize its prefusion conformation. However, contemporary me
Externí odkaz:
https://doaj.org/article/edd8cd5ae497476d8f8b6a6d91cc4a43
Autor:
Ruipeng Lei, Timothy J. C. Tan, Andrea Hernandez Garcia, Yiquan Wang, Meghan Diefenbacher, Chuyun Teo, Gopika Gopan, Zahra Tavakoli Dargani, Qi Wen Teo, Claire S. Graham, Christopher B. Brooke, Satish K. Nair, Nicholas C. Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Lei et al. systematically characterized the epistasis among natural mutations in the neuraminidase of human influenza H3N2 virus, which provide insights into the biophysical constraints that shaped its evolution trajectory over the past half-century.
Externí odkaz:
https://doaj.org/article/0633989677a641f4aaf53b86462782b0
Autor:
Tim Schulte, Marc D. Panas, Xiao Han, Lucy Williams, Nancy Kedersha, Jonas Simon Fleck, Timothy J. C. Tan, Xaquin Castro Dopico, Anders Olsson, Ainhoa Moliner Morro, Leo Hanke, Johan Nilvebrant, Kim Anh Giang, Per-Åke Nygren, Paul Anderson, Adnane Achour, Gerald M. McInerney
Publikováno v:
Open Biology, Vol 13, Iss 5 (2023)
G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formati
Externí odkaz:
https://doaj.org/article/719e066a65f94ead97a58a120d59ffcd
Autor:
null Tim Schulte, null Marc D. Panas, null Xiao Han, null Lucy Williams, null Nancy Kedersha, null Jonas Simon Fleck, null Timothy J. C. Tan, null Xaquin Castro Dopico, null Anders Olsson, null Ainhoa Moliner Morro, null Leo Hanke, null Johan Nilvebrant, null Kim Anh Giang, null Per-Åke Nygren, null Paul Anderson, null Adnane Achour, null Gerald M. McInerney
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f406bebec2fbab5f7e9a3dbba5cb3d3
https://doi.org/10.1098/rsob.220369/v2/response1
https://doi.org/10.1098/rsob.220369/v2/response1
Publikováno v:
Virology. 557:86-99
The distributions of the rac1, rhoA and cdc42 proteins in respiratory syncytial virus (RSV) infected cells was examined. All three rhoGTPases were detected within inclusion bodies, and while the rhoA and rac1 proteins were associated with virus filam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57051f3bd76d79cb561149fdf08ae3e
https://doi.org/10.1016/j.virol.2021.02.008
https://doi.org/10.1016/j.virol.2021.02.008
Autor:
Meghan Diefenbacher, Timothy J. C. Tan, David L. V. Bauer, Beth M. Stadtmueller, Nicholas C. Wu, Christopher B. Brooke
Publikováno v:
J Virol
The influenza A virus (IAV) genome is divided into eight negative-sense, single-stranded RNA segments. Each segment exhibits a unique level and temporal pattern of expression; however, the exact mechanisms underlying the patterns of individual gene s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa1f76a43fb074597ba27a96c4e1991
https://doi.org/10.1128/jvi.00205-22
https://doi.org/10.1128/jvi.00205-22