Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Timothy J, Satchwell"'
Autor:
Nadine R King, Catarina Martins Freire, Jawida Touhami, Marc Sitbon, Ashley M Toye, Timothy J Satchwell
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011989 (2024)
Plasmodium falciparum invasion of the red blood cell is reliant upon the essential interaction of PfRh5 with the host receptor protein basigin. Basigin exists as part of one or more multiprotein complexes, most notably through interaction with the mo
Externí odkaz:
https://doaj.org/article/5e03a73c231a44a6b00d65a0a3ad2f00
Autor:
Timothy J. Satchwell
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Parasites of the genus Plasmodium that cause malaria survive within humans by invasion of, and proliferation within, the most abundant cell type in the body, the red blood cell. As obligate, intracellular parasites, interactions between parasite and
Externí odkaz:
https://doaj.org/article/034c13609ce949e3bb302e193fd31d69
Autor:
Timothy J. Satchwell, Ashley M. Toye
Publikováno v:
Haematologica, Vol 106, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/b2b00521e7ba4bb3a15c08f59b60c6ec
Autor:
Timothy J. Satchwell, Katherine E. Wright, Katy L. Haydn-Smith, Fernando Sánchez-Román Terán, Pedro L. Moura, Joseph Hawksworth, Jan Frayne, Ashley M. Toye, Jake Baum
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Here, the authors show that reticulocytes derived from immortalized erythroblasts support invasion and development of Plasmodium falciparum and use CRISPR-mediated gene knockout and complementation of an invasion receptor to demonstrate utility of th
Externí odkaz:
https://doaj.org/article/cb05acb78a2c45d997fced9f3abed603
Autor:
Vanja Karamatic Crew, Louise A. Tilley, Timothy J. Satchwell, Samah A. AlSubhi, Benjamin Jones, Frances A. Spring, Piers J. Walser, Catarina Martins Freire, Nicoletta Murciano, Maria Giustina Rotordam, Svenja J. Woestmann, Marwa Hamed, Reem Alradwan, Mouza AlKhrousey, Ian Skidmore, Sarah Lewis, Shimon Hussain, Jane Jackson, Tom Latham, Mark D. Kilby, William Lester, Nadine Becker, Markus Rapedius, Ashley M. Toye, Nicole M. Thornton
Publikováno v:
Karamatic Crew, V, Tilley, L A, Satchwell, T, Alsubhi, S A O, Toye, A M & Thornton, N M 2023, ' Missense mutations in PIEZO1, which encodes the Piezo1 mechanosensor protein, define Er red blood cell antigens ', Blood, vol. 141, no. 2, pp. 135-146 . https://doi.org/10.1182/blood.2022016504
Despite the identification of the high-incidence red cell antigen Era nearly 40 years ago, the molecular background of this antigen, together with the other 2 members of the Er blood group collection, has yet to be elucidated. Whole exome and Sanger
Autor:
Pedro L. Moura, Bethan R. Hawley, Johannes G.G. Dobbe, Geert J. Streekstra, Minke A.E. Rab, Paola Bianchi, Richard van Wijk, Ashley M. Toye, Timothy J. Satchwell
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/34e9fdc0ee9a44b39974e66ec86ad2c4
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract CD47 is an important ‘marker of self’ protein with multiple isoforms produced though alternative splicing that exhibit tissue-specific expression. Mature erythrocytes express CD47 isoform 2 only, with membrane stability of this version d
Externí odkaz:
https://doaj.org/article/43a7585e505d4217995ea2df63452c52
Autor:
Kongtana Trakarnsanga, Rebecca E. Griffiths, Marieangela C. Wilson, Allison Blair, Timothy J. Satchwell, Marjolein Meinders, Nicola Cogan, Sabine Kupzig, Ryo Kurita, Yukio Nakamura, Ashley M. Toye, David J. Anstee, Jan Frayne
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
The generation of a sustainable supply of erythroid progenitors is essential for the reliable production of anin vitroderived red blood cell clinical product. Here the authors immortalize early human erythroblasts to generate the first cell line capa
Externí odkaz:
https://doaj.org/article/43660dc1c27e4e12acb966c38920743b
Autor:
Pedro L. Moura, Bethan R. Hawley, Tosti J. Mankelow, Rebecca E. Griffiths, Johannes G.G. Dobbe, Geert J. Streekstra, David J. Anstee, Timothy J. Satchwell, Ashley M. Toye
Publikováno v:
Haematologica, Vol 103, Iss 12 (2018)
The process of maturation of reticulocytes into fully mature erythrocytes that occurs in the circulation is known to be characterized by a complex interplay between loss of cell surface area and volume, removal of remnant cell organelles and redundan
Externí odkaz:
https://doaj.org/article/e83ca56a8d8646e5aab645c91c80e34f
Autor:
Joseph Hawksworth, Timothy J Satchwell, Marjolein Meinders, Deborah E Daniels, Fiona Regan, Nicole M Thornton, Marieangela C Wilson, Johannes GG Dobbe, Geert J Streekstra, Kongtana Trakarnsanga, Kate J Heesom, David J Anstee, Jan Frayne, Ashley M Toye
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 6, Pp n/a-n/a (2018)
Abstract Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle‐cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level
Externí odkaz:
https://doaj.org/article/9af938bdb64040d3b9bf6a27b7e9cbb8