Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Timothy J, Martins"'
1
Akademický článek
Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs
Autor: Chan-Jung Chang, Andriana G. Kotini, Malgorzata Olszewska, Maria Georgomanoli, Julie Teruya-Feldstein, Henrik Sperber, Roberto Sanchez, Robert DeVita, Timothy J. Martins, Omar Abdel-Wahab, Robert K. Bradley, Eirini P. Papapetrou
Publikováno v: Stem Cell Reports, Vol 10, Iss 5, Pp 1610-1624 (2018)
Summary: Connecting specific cancer genotypes with phenotypes and drug responses constitutes the central premise of precision oncology but is hindered by the genetic complexity and heterogeneity of primary cancer cells. Here, we use patient-derived i
Externí odkaz: https://doaj.org/article/abed14ae57fa41e0af931090a4cb672c
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2
Akademický článek
A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia
Autor: Su-In Lee, Safiye Celik, Benjamin A. Logsdon, Scott M. Lundberg, Timothy J. Martins, Vivian G. Oehler, Elihu H. Estey, Chris P. Miller, Sylvia Chien, Jin Dai, Akanksha Saxena, C. Anthony Blau, Pamela S. Becker
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Identification of markers of drug response is essential for precision therapy. Here the authors introduce an algorithm that uses prior information about each gene’s importance in AML to identify the most predictive gene-drug associations from trans
Externí odkaz: https://doaj.org/article/ff277a1927e34d3491a2ec37c88816b8
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3
Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
Autor: Guangrong Qin, Jin Dai, Sylvia Chien, Timothy J. Martins, Brenda Loera, Quy Nguyen, Melanie L. Oakes, Bahar Tercan, Boris Aguilar, Lauren Hagen, Jeannine McCune, Richard Gelinas, Raymond J. Monnat, Ilya Shmulevich, Pamela S. Becker
Acute myeloid leukemia (AML) is an aggressive malignancy of myeloid progenitor cells characterized by successive acquisition of genetic alterations. This inherent heterogeneity poses challenges in the development of precise and effective therapies. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8319f859d807a96395214f8382eacf71
https://doi.org/10.1101/2023.05.24.541944
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8
High-Throughput Drug Screening and Multi-Omic Analysis to Guide Individualized Treatment for Multiple Myeloma
Autor: Alicia J. Morales, Edus H. Warren, Damian J. Green, Edward N. Libby, Pamela S. Becker, Bret Gary Degraaff, Timothy J. Martins, Rebecca Silbermann, Andrew J. Cowan, Niall Curley, Sylvia Chien, Jin Dai, Ted Gooley, David G. Coffey
Publikováno v: JCO Precis Oncol
PURPOSE Multiple myeloma (MM) is a genetically heterogeneous malignancy characterized by variable treatment responses. Although numerous drugs have been approved in recent years, the ability to predict treatment response and tailor individual therapy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82151d0377118a88e1d37f7248ca65b0
https://pubmed.ncbi.nlm.nih.gov/34250400
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9
Akademický článek
WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.
Autor: Richard G James, Kathryn C Davidson, Katherine A Bosch, Travis L Biechele, Nicholas C Robin, Russell J Taylor, Michael B Major, Nathan D Camp, Kerry Fowler, Timothy J Martins, Randall T Moon
Publikováno v: PLoS ONE, Vol 7, Iss 12, p e50457 (2012)
The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signali
Externí odkaz: https://doaj.org/article/12d177eee11747f8bf4fe88ef3e0fb58
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10
Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs
Autor: Robert K. Bradley, Eirini P. Papapetrou, Roberto Sanchez, Robert J. DeVita, Julie Teruya-Feldstein, Timothy J. Martins, Maria Georgomanoli, Andriana G. Kotini, Henrik Sperber, Chan Jung Chang, Malgorzata Olszewska, Omar Abdel-Wahab
Publikováno v: Stem Cell Reports, Vol 10, Iss 5, Pp 1610-1624 (2018)
Stem Cell Reports
Summary Connecting specific cancer genotypes with phenotypes and drug responses constitutes the central premise of precision oncology but is hindered by the genetic complexity and heterogeneity of primary cancer cells. Here, we use patient-derived in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8e9f745824bb59e983447b11b44246
https://doi.org/10.1016/j.stemcr.2018.03.020
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