Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome

Autor: Amanda M. Smith, Taylor A. LaValle, Marwan Shinawi, Sai M. Ramakrishnan, Haley J. Abel, Cheryl A. Hill, Nicole M. Kirkland, Michael P. Rettig, Nichole M. Helton, Sharon E. Heath, Francesca Ferraro, David Y. Chen, Sangeeta Adak, Clay F. Semenkovich, Diana L. Christian, Jenna R. Martin, Harrison W. Gabel, Christopher A. Miller, Timothy J. Ley

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Germline mutations in the DNMT3A gene can cause an overgrowth syndrome associated with behavioural and hematopoietic phenotypes. Here the authors describe a mouse model of this syndrome that recapitulates many of these features, including conserved a

Externí odkaz: https://doaj.org/article/5e0d8e3763324ed0920eb1d6b6fbeadf

Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells

Autor: Amanda M. Smith, Angela M. Verdoni, Haley J. Abel, David Y. Chen, Shamika Ketkar, Elizabeth R. Leight, Christopher A. Miller, Timothy J. Ley

Publikováno v: iScience, Vol 25, Iss 4, Pp 104004- (2022)

Summary: Mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) are the most common cause of clonal hematopoiesis and are among the most common initiating events of acute myeloid leukemia (AML). Studies in germline and somatic Dnmt3a knocko

Externí odkaz: https://doaj.org/article/01b3d370f1c6454ba941449503cd5b03

Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression

Autor: Jessica M. Silva-Fisher, Ha X. Dang, Nicole M. White, Matthew S. Strand, Bradley A. Krasnick, Emily B. Rozycki, Gejae G. L. Jeffers, Julie G. Grossman, Maureen K. Highkin, Cynthia Tang, Christopher R. Cabanski, Abdallah Eteleeb, Jacqueline Mudd, S. Peter Goedegebuure, Jingqin Luo, Elaine R. Mardis, Richard K. Wilson, Timothy J. Ley, Albert C. Lockhart, Ryan C. Fields, Christopher A. Maher

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

The role of long non-coding RNAs (lncRNAs) in metastatic colorectal cancer (mCRC) and treatment resistance is unclear. Here, the authors use transcriptome sequencing of matched normal, primary, and metastatic CRC tissues to discover and validate that

Externí odkaz: https://doaj.org/article/419e0097c4524d55a96202eb846d0823

Tumor suppressor function of WT1 in acute promyelocytic leukemia

Autor: Matthew J. Christopher, Casey D. S. Katerndahl, Hayley R. LeBlanc, Tyler T. Elmendorf, Vaishali Basu, Margery Gang, Andrew J. Menssen, David H. Spencer, Eric J. Duncavage, Shamika Ketkar, Lukas D. Wartman, Sai Mukund Ramakrishnan, Christopher A. Miller, Timothy J. Ley

Publikováno v: Haematologica, Vol 107, Iss 1 (2021)

Externí odkaz: https://doaj.org/article/3db7069ffa6a432d938d4fd62f49a828

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

Autor: Georgina L. Ryland, Masayuki Umeda, Linda Holmfeldt, Sören Lehmann, Morten Krogh Herlin, Jing Ma, Mahsa Khanlari, Jeffrey E. Rubnitz, Rhonda E. Ries, Hansen J. Kosasih, Paul G. Ekert, Hwee Ngee Goh, Ing S. Tiong, Sean M. Grimmond, Claudia Haferlach, Ryan B. Day, Timothy J. Ley, Soheil Meshinchi, Xiaotu Ma, Piers Blombery, Jeffery M. Klco

Publikováno v: Ryland, G, Umeda, M, Holmfeldt, L, Lehmann, S, Herlin, M K, Ma, J J, Khanlari, M, Rubnitz, J E, Ries, R E, Kosasih, H J, Ekert, P G, Goh, H N, Tiong, I S, Grimmond, S M, Haferlach, C, Day, R B, Ley, T J, Meshinchi, S, Ma, X, Blombery, P & Klco, J M 2023, ' Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions ', Blood, vol. 141, no. 7, pp. 800-805 . https://doi.org/10.1182/blood.2022017874

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7b10821fb0a0a1f6a90fd2b733b17a
https://doi.org/10.1182/blood.2022017874