Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Timothy J, Kottke"'
2
Data from Antibody-Neutralized Reovirus Is Effective in Oncolytic Virotherapy
Autor: Elizabeth J. Ilett, Alan Melcher, Richard G. Vile, Rob C. Hoeben, Matthew Coffey, Jill Thompson, Timothy J. Kottke, Diana J.M. van den Wollenberg, Aat A. Mulder, Lynette P. Steele, Robert A. Berkeley
Immunotherapy is showing promise for otherwise incurable cancers. Oncolytic viruses (OVs), developed as direct cytotoxic agents, mediate their antitumor effects via activation of the immune system. However, OVs also stimulate antiviral immune respons
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::873a76180c6ebb21fa1a1842d2697f96
https://doi.org/10.1158/2326-6066.c.6547988.v1
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6
The Efficacy Versus Toxicity Profile of Combination Virotherapy and TLR Immunotherapy Highlights the Danger of Administering TLR Agonists to Oncolytic Virus-treated Mice
Autor: Diana M, Rommelfanger, Marta, Compte, Marta C, Grau, Rosa M, Diaz, Elizabeth, Ilett, Luis, Alvarez-Vallina, Jill M, Thompson, Timothy J, Kottke, Alan, Melcher, Richard G, Vile
Publikováno v: Molecular Therapy. 21:348-357
Injection of oncolytic vesicular stomatitis virus (VSV) into established B16ova melanomas results in tumor regression, in large part by inducing innate immune reactivity against the viral infection, mediated by MyD88- and type III interferon (IFN)-,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a802cf364f558a3bf50f813b800c8cc
https://doi.org/10.1038/mt.2012.204
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7
Phosphorylated Forms of Activated Caspases Are Present in Cytosol From HL-60 Cells During Etoposide-Induced Apoptosis
Autor: Luis M. Martins, Timothy J. Kottke, Scott H. Kaufmann, William C. Earnshaw
Publikováno v: Blood. 92:3042-3049
Treatment of HL-60 human leukemia cells with etoposide induces apoptotic cell death and activation of at least 18 electrophoretically distinct cysteine-dependent aspartate-directed protease (caspase) isoforms, several of which differ only in their is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0891324db838365f741f9354a8099cb7
https://doi.org/10.1182/blood.v92.9.3042.421k55_3042_3049
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8
Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis
Autor: Luis M. Martins, Peter W. Mesner, Timothy J. Kottke, Guriqbal S. Basi, Sukanto Sinha, Jay S. Tung, Phyllis A. Svingen, Benjamin J. Madden, Atsushi Takahashi, Daniel J. McCormick, William C. Earnshaw, Scott H. Kaufmann
Publikováno v: Blood. 90:4283-4296
Previous studies have shown that K562 chronic myelogenous leukemia cells are resistant to induction of apoptosis by a variety of agents, including the topoisomerase II (topo II) poison etoposide, when examined 4 to 24 hours after treatment with an in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0418b831720e2dc88053f7fed55b1ce
https://doi.org/10.1182/blood.v90.11.4283
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9
Comparison of Apoptosis in Wild-Type and Fas-Resistant Cells: Chemotherapy-Induced Apoptosis Is Not Dependent on Fas/Fas Ligand Interactions
Autor: Christine M. Eischen, Timothy J. Kottke, Luis M. Martins, Guriqbal S. Basi, Jay S. Tung, William C. Earnshaw, Paul J. Leibson, Scott H. Kaufmann
Publikováno v: Blood. 90:935-943
The Fas/Fas ligand (FasL) pathway is widely involved in apoptotic cell death in lymphoid and nonlymphoid cells. It has recently been postulated that many chemotherapeutic agents also induce cell death by activating the Fas/FasL pathway. In the presen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9c10e09d049a2ef3b19fe7a28dde162
https://doi.org/10.1182/blood.v90.3.935
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