Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Timothy J, Kieffer"'
Autor:
Jia Zhao, Shenghui Liang, Haoning Howard Cen, Yanjun Li, Robert K. Baker, Balwinder Ruprai, Guang Gao, Chloe Zhang, Huixia Ren, Chao Tang, Liangyi Chen, Yanmei Liu, Francis C. Lynn, James D. Johnson, Timothy J. Kieffer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Remarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from current approaches, we devised a tunable strategy to generate islet spheroids enr
Externí odkaz:
https://doaj.org/article/1bdf64aed5f74d41bf7cbec2f67ff56c
Autor:
Diepiriye G. Iworima, Robert K. Baker, Cara Ellis, Chris Sherwood, Lisa Zhan, Alireza Rezania, James M. Piret, Timothy J. Kieffer
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Background Diabetes is a disease affecting over 500 million people globally due to insulin insufficiency or insensitivity. For individuals with type 1 diabetes, pancreatic islet transplantation can help regulate their blood glucose levels. H
Externí odkaz:
https://doaj.org/article/eef5378a3b1e42df99f87e9d84023768
Autor:
Mitchell J. S. Braam, Jia Zhao, Shenghui Liang, Shogo Ida, Nick K. Kloostra, Diepiriye G. Iworima, Mei Tang, Robert K. Baker, Nina Quiskamp, James M. Piret, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The generation of functional β-cells from human pluripotent stem cells (hPSCs) for cell replacement therapy and disease modeling of diabetes is being investigated by many groups. We have developed a protocol to harvest and aggregate hPSC-de
Externí odkaz:
https://doaj.org/article/fad7c7701c714b55ac516ffdf75998a9
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Human pluripotent stem cells (hPSCs) provide many opportunities for application in regenerative medicine due to their ability to differentiate into cells from all three germ layers, proliferate indefinitely, and replace damaged or dysfu
Externí odkaz:
https://doaj.org/article/ea6232bfd13f4492920ebb3a18c3c90b
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 11, Pp 1459-1469 (2021)
Abstract Diabetes is a debilitating disease characterized by high blood glucose levels. The global prevalence of this disease has been projected to reach 700 million adults by the year 2045. Type 1 diabetes represents about 10% of the reported cases
Externí odkaz:
https://doaj.org/article/7011b7906fd14df3be74e2ac98c569c7
Autor:
Sandra Pereira, Daemon L. Cline, Melissa Chan, Kalin Chai, Ji Soo Yoon, Shannon M. O’Dwyer, Cara E. Ellis, Maria M. Glavas, Travis D. Webber, Robert K. Baker, Suheda Erener, Scott D. Covey, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Although innate immunity is linked to metabolic health, the effect of leptin signaling in cells from the innate immune system on glucose homeostasis has not been thoroughly investigated. We generated two mouse models using Cre-lox methodolog
Externí odkaz:
https://doaj.org/article/c76ba490337d4d6ea06ec89d31cd8b29
Autor:
Maria M. Glavas, Queenie Hui, Ian Miao, Fan Yang, Suheda Erener, Kacey J. Prentice, Michael B. Wheeler, Timothy J. Kieffer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Overconsumption of saturated fats promotes obesity and type 2 diabetes. Excess weight gain in early life may be particularly detrimental by promoting earlier diabetes onset and potentially by adversely affecting normal development. In the pr
Externí odkaz:
https://doaj.org/article/4dfa192eb736486bb29246613caa1b5a
Autor:
Suheda Erener, Cara E. Ellis, Adam Ramzy, Maria M. Glavas, Shannon O’Dwyer, Sandra Pereira, Tom Wang, Janice Pang, Jennifer E. Bruin, Michael J. Riedel, Robert K. Baker, Travis D. Webber, Marina Lesina, Matthias Blüher, Hana Algül, Janel L. Kopp, Stephan Herzig, Timothy J. Kieffer
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 11, Pp 100434- (2021)
Summary: miRNAs have crucial functions in many biological processes and are candidate biomarkers of disease. Here, we show that miR-216a is a conserved, pancreas-specific miRNA with important roles in pancreatic islet and acinar cells. Deletion of mi
Externí odkaz:
https://doaj.org/article/72b68c0d6c1547c3b0a24daccc37c95f
Autor:
Corinne A. Hoesli, Timothy J. Kieffer
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 11, Pp 100454- (2021)
Summary: In Cell Stem Cell, Aghazadeh et al.1 show that human embryonic stem cell-derived pancreatic progenitors can reverse hyperglycemia for several weeks in streptozotocin-induced diabetic mice when co-transplanted with microvessel fragments into
Externí odkaz:
https://doaj.org/article/5fbd1fc133164ad9804f282ea7abb35e
Autor:
Satoko Shimazu‐Kuwahara, Yoshinori Kanemaru, Norio Harada, Eri Ikeguchi, Yohei Ueda, Shunsuke Yamane, Yuki Murata, Akihiro Yasoda, Timothy J Kieffer, Nobuya Inagaki
Publikováno v:
Journal of Diabetes Investigation, Vol 10, Iss 4, Pp 909-914 (2019)
Abstract Given the established roles of glucose‐dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green
Externí odkaz:
https://doaj.org/article/656fc3cc51de4cdb87469659c45eee6b