Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Timothy J, Jarome"'
Autor:
Morgan B. Patrick, Natalie J. Preveza, Shannon E. Kincaid, Gueladouan Setenet, Jennifer R. Abraham, Adam Cummings, Shifa Banani, W. Keith Ray, Richard F. Helm, Sydney Trask, Timothy J. Jarome
Publikováno v:
Brain Research Bulletin, Vol 215, Iss , Pp 111015- (2024)
The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells and dysregulation of the UPS has been implicated in the pathophysiology of numerous neurodegenerative disorders, including Alzheimer’s disease. Further, str
Externí odkaz:
https://doaj.org/article/e486658b1c924010a42b05f52996e968
Autor:
Kayla Farrell, Aubrey Auerbach, Catherine Liu, Kiley Martin, Myasia Pareno, W. Keith Ray, Richard F. Helm, Fernando Biase, Timothy J. Jarome
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background Sex differences have been observed in several brain regions for the molecular mechanisms involved in baseline (resting) and memory-related processes. The ubiquitin proteasome system (UPS) is a major protein degradation pathway in
Externí odkaz:
https://doaj.org/article/a5310153294e43739689cf12b644a0a3
Autor:
Taylor McFadden, Natasha Gaito, Isabella Carucci, Everett Fletchall, Kayla Farrell, Timothy J Jarome
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284286 (2023)
Obesity is a complex medical condition that is linked to various health complications such as infertility, stroke, and osteoarthritis. Understanding the neurobiology of obesity is crucial for responding to the etiology of this disease. The hypothalam
Externí odkaz:
https://doaj.org/article/c2e06b73304540fcbc27e2fb56bda1ee
Autor:
Kayla Farrell, Madeline Musaus, Shaghayegh Navabpour, Kiley Martin, W. Keith Ray, Richard F. Helm, Timothy J. Jarome
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Ubiquitin-proteasome mediated protein degradation has been widely implicated in fear memory formation in the amygdala. However, to date, the protein targets of the proteasome remain largely unknown, limiting our understanding of the functional signif
Externí odkaz:
https://doaj.org/article/8a909226cb1b417d9bdd8914a309ccb7
Autor:
Madeline Musaus, Kayla Farrell, Shaghayegh Navabpour, W. Keith Ray, Richard F. Helm, Timothy J. Jarome
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Strong evidence supports that protein ubiquitination is a critical regulator of fear memory formation. However, as this work has focused on protein degradation, it is currently unknown whether polyubiquitin modifications that are independent of the p
Externí odkaz:
https://doaj.org/article/5ccbedcb49384a85a0ebf93b9e95e914
Publikováno v:
Learning & Memory. 30:70-73
Strong evidence has implicated proteasome-mediated protein degradation in the memory consolidation process. However, due to the use of pharmacological approaches, the cell type specificity of this remains unknown. Here, we used neuron-specific and no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d6a2beadb6924140e821084366936a
https://doi.org/10.1101/lm.053716.122
https://doi.org/10.1101/lm.053716.122
Publikováno v:
Nutritional neuroscience.
Previous work has shown that exposure to a high fat diet dysregulates the protein degradation process in the hypothalamus of male rodents. However, whether this occurs in a sex-independent manner is unknown. The objective of this study was to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b4216713cbfd573ea53ebbe1c4b3dd
https://pubmed.ncbi.nlm.nih.gov/35282800
https://pubmed.ncbi.nlm.nih.gov/35282800
Publikováno v:
Learning & Memory. 29:256-264
Reports of sex differences in the neurobiology of memory formation are becoming more prevalent. Despite this, much remains unknown about the role of sex in this process. We previously reported the first evidence of a novel epigenetic role for proteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4948fdca63c5acc61025807372073f12
https://doi.org/10.1101/lm.053498.121
https://doi.org/10.1101/lm.053498.121
Autor:
Kayla Farrell, Madeline Musaus, Aubrey Auerbach, Shaghayegh Navabpour, W. Keith Ray, Richard F. Helm, Timothy J. Jarome
Publikováno v:
Molecular Psychiatry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbdba100ea13032537c17b9a5341f7cf
https://doi.org/10.1038/s41380-023-02112-0
https://doi.org/10.1038/s41380-023-02112-0
Autor:
Kayla Farrell, Timothy J. Jarome
Publikováno v:
Expert Opin Drug Discov
INTRODUCTION: Central nervous system (CNS) diseases affect a large portion of the population, however, few therapeutic options are available. Furthermore, to date, clinical trials have been largely unsuccessful due to difficulty in targeting the undr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630a1fd09049986b74e534076b298a99
https://doi.org/10.1080/17460441.2021.1915979
https://doi.org/10.1080/17460441.2021.1915979