Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Timothy J, Egan"'
Autor:
Oluwatoba E. Oyeneyin, Rashmika Moodley, Chakes Mashaba, Larnelle F. Garnie, Damilola A. Omoboyowa, Goitsemodimo H. Rakodi, Mabuatsela V. Maphoru, Mohamed O. Balogun, Heinrich C. Hoppe, Timothy J. Egan, Matshawandile Tukulula
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38434- (2024)
Quinoline-urea-benzothiazole hybrids exhibited low to sub-micromolar in vitro activities against the Plasmodium falciparum (P. falciparum) 3D7 chloroquine (CQ)-sensitive strain, with compounds 5a, 5b and 5f showing activities ranging from 0.33 to 0.9
Externí odkaz:
https://doaj.org/article/f3d05a9023a946b38321cc55323184d8
Autor:
Alexa Redway, Christina Spry, Ainka Brown, Ursula Wiedemann, Imam Fathoni, Larnelle F. Garnie, Deyun Qiu, Timothy J. Egan, Adele M. Lehane, Yvette Jackson, Kevin J. Saliba, Nadale Downer-Riley
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100536- (2024)
Malaria continues to be a significant burden, particularly in Africa, which accounts for 95% of malaria deaths worldwide. Despite advances in malaria treatments, malaria eradication is hampered by insecticide and antimalarial drug resistance. Consequ
Externí odkaz:
https://doaj.org/article/7c9a9489f8234aad9bd8dd478692ccf0
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The biomineral haemozoin, or its synthetic analogue β-haematin (βH), has been the focus of several target-based screens for activity against Plasmodium falciparum parasites. Together with the known βH crystal structure, the availability o
Externí odkaz:
https://doaj.org/article/0e9d9577f75f4ad3b7611cf98b1a8ed3
Autor:
Phanankosi Moyo, William Shamburger, Mariëtte E. van der Watt, Janette Reader, Ana Carolina C. de Sousa, Timothy J. Egan, Vinesh J. Maharaj, Gerhard Bringmann, Lyn-Marie Birkholtz
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 51-58 (2020)
The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual and sexual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, we report the validatio
Externí odkaz:
https://doaj.org/article/642b4370fc534b02bced97c3b270352b
Autor:
Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig, Sabine Ottilie, Madeline R. Luth, Tilla S. Worgall, Gregory M. Goldgof, Roxanne Mohunlal, T. R. Santha Kumar, Jennifer K. Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M. Williams, Bing Yu Zou, Andrea L. Cheung, Prianka Kumar, Timothy J. Egan, Marcus C. S. Lee, Dionicio Siegel, Alan F. Cowman, David A. Fidock, Elizabeth A. Winzeler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and expo
Externí odkaz:
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Malaria remains a major public health problem. With the loss of antimalarials to resistance, the malaria burden will likely continue for decades. New antimalarial scaffolds are crucial to avoid cross-resistance. Here, we present the first st
Externí odkaz:
https://doaj.org/article/83eb3cf1f04445ff916522570afe1d21
Autor:
John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J. Wicht, Lubbe Wiesner, Timothy J. Egan, Kelly Chibale
Publikováno v:
ACS Infectious Diseases. 9:653-667
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a808c9aa7fae607b836d3485b45e3752
https://doi.org/10.1021/acsinfecdis.2c00592
https://doi.org/10.1021/acsinfecdis.2c00592
Autor:
Yolanda Corbett, Sarah D’Alessandro, Silvia Parapini, Diletta Scaccabarozzi, Parisa Kalantari, Stefania Zava, Flavio Giavarini, Donatella Caruso, Irma Colombo, Timothy J. Egan, Nicoletta Basilico
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-13 (2018)
Abstract Background Plasmodium falciparum haemozoin, a detoxification product of digested haemoglobin from infected erythrocytes, is released into the bloodstream upon schizont rupture and accumulates in leukocytes. High levels of haemozoin correlate
Externí odkaz:
https://doaj.org/article/2e2ff387e315404e9e007287f3870327
Autor:
Dickson Mambwe, Constance M. Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J. Egan, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 65:16695-16715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be13f3671115eb74fe7def09b01a1d32
https://doi.org/10.1021/acs.jmedchem.2c01516
https://doi.org/10.1021/acs.jmedchem.2c01516
Publikováno v:
Molecules, Vol 25, Iss 7, p 1571 (2020)
With the continued loss of antimalarials to resistance, drug repositioning may have a role in maximising efficiency and accelerating the discovery of new antimalarial drugs. Bayesian statistics was previously used as a tool to virtually screen USFDA
Externí odkaz:
https://doaj.org/article/4b3871f4e07042548a4b9a0e1ffcf607