Výsledky vyhledávání - "Timothy J, Davies"

Akademický článek

Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset

Autor: Patty Sachamitr, Alison J. Leishman, Timothy J. Davies, Paul J. Fairchild

Publikováno v: Frontiers in Immunology, Vol 8 (2018)

The advent of induced pluripotent stem cells (iPSCs) has begun to revolutionize cell therapy by providing a convenient source of rare cell types not normally available from patients in sufficient numbers for therapeutic purposes. In particular, the d

Externí odkaz: https://doaj.org/article/e0e2deeca77045eca29ba49e35851cb6

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Towards the rational design of a next-generation dendritic cell vaccine for cancer immunotherapy

Autor: Timothy J. Davies, Marcelo Bravo, Paul J. Fairchild

Publikováno v: Cell and Gene Therapy Insights. 7:637-650

As professional antigen presenting cells (APCs) capable of eliciting primary immune responses among naïve T cells, dendritic cells (DCs) offer an attractive target for immune intervention. While some strategies for vaccination have sought to deliver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a73ffafd0ec891ba35269246a27042
https://doi.org/10.18609/cgti.2021.086

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Ten Years of Population-Level Genomic Escherichia coli and Klebsiella pneumoniae Serotype Surveillance Informs Vaccine Development for Invasive Infections

Autor: Samuel Lipworth, James Kavanagh, Katie Jeffery, Derrick W. Crook, Marcus Morgan, Nicole Stoesser, Karina-Doris Vihta, Ali Vaughan, Kevin K Chau, Leanne Barker, Sarah Oakley, Timothy J. Davies, Tim E. A. Peto, Monique Andersson, A. Sarah Walker, Sophie George

Publikováno v: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

Background The incidence of bloodstream infections (BSIs) caused by Escherichia coli and Klebsiella pneumoniae is increasing, with substantial associated morbidity, mortality, and antimicrobial resistance. Unbiased serotyping studies to guide vaccine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eafa338114b00a947de6e5e6bb0a5e
http://europepmc.org/articles/PMC8677521

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Discordance between different bioinformatic methods for identifying resistance genes from short-read genomic data, with a focus on Escherichia coli

Autor: Timothy J. Davies, Muna F. Anjum, Philip W. Fowler, Susan Hopkins, A. Sarah Walker, Nicole Stoesser, Katie Hopkins, Anna E. Sheppard, Derrick W. Crook, Matthew Ellington, Tim E. A. Peto, Jeremy Swan, H Pickford, Manal AbuOun, Samuel Lipworth

2.AbstractSeveral bioinformatics genotyping algorithms are now commonly used to characterise antimicrobial resistance (AMR) gene profiles in whole genome sequencing (WGS) data, with a view to understanding AMR epidemiology and developing resistance p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9c96eaaf2d7d8e8d58a04c8c95132ce
https://doi.org/10.1101/2021.11.03.467004

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Induced pluripotent stem cells reprogrammed from primary dendritic cells provide an abundant source of immunostimulatory dendritic cells for use in immunotherapy

Autor: Priyoshi Lahiri, Christopher Horton, Paul J. Fairchild, Patty Sachamitr, Timothy J. Davies

Publikováno v: Stem Cells (Dayton, Ohio)

Cell types differentiated from induced pluripotent stem cells (iPSCs) are frequently arrested in their development program, more closely resembling a fetal rather than an adult phenotype, potentially limiting their utility for downstream clinical app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c588af8163bdea20b958a86fdfad320f
https://doi.org/10.1002/stem.3095

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'Just not knowing' can make life sweeter (and saltier): Reward uncertainty alters the sensory experience and consumption of palatable food and drinks

Autor: John A. Parkinson, Timothy J. Davies, Robert D. Rogers, Aaron M Cahill, Gregory J. Madden, Alexandra Witt, Samantha K Millard, Paul Rauwolf, Nicole Wong

Publikováno v: Journal of experimental psychology. General. 150(10)

Reward uncertainty can prompt exploration and learning, strengthening approach and consummatory behaviors. For humans, these phenomena are exploited in marketing promotions and gambling products, sometimes spurring hedonic consumption. Here, in four

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b554a5767cf93d539a9f922a48eff3
https://pubmed.ncbi.nlm.nih.gov/33734772

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An ecological comparison of hospital-level antibiotic use and mortality in 36,124,372 acute/general medicine inpatients in England

Autor: Susan Hopkins, Martin J. Gill, T Donker, Eric Budgell, Timothy J. Davies, David H. Wyllie, Martin J. Llewelyn, A S Walker, Peto Tea.

ObjectivesTo determine the extent to which variation in hospital antibiotic prescribing is associated with mortality risk in acute/general medicine inpatients.DesignEcological analysis, using electronic health records from Hospital Episode Statistics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34f37d1511b1e72e91f14e0100e915e5
https://doi.org/10.1101/2020.09.24.20199448

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Ten years of population-level genomic Escherichia coli and Klebsiella pneumoniae serotype surveillance informs vaccine development for invasive infections

Autor: Timothy J. Davies, A. Sarah Walker, Leanne Barker, Kevin K Chau, Sarah Oakley, Katie Jeffery, Monique Andersson, Nicole Stoesser, Karina-Doris Vihta, Ali Vaughan, Samuel Lipworth, Derrick W. Crook, Sophie George, Tim E. A. Peto, James Kavanagh, Marcus Morgan

The incidence of bloodstream infections (BSIs) caused by Enterobacteriaceae (e.g. Escherichia coli, Klebsiella pneumoniae) continues to increase globally and the threat of untreatable disease is substantial1. Prophylactic vaccines represent an altern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1eba1c2f9783ccf8c9b78822e1429c9
https://doi.org/10.1101/2020.07.08.20140707

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Modelling reaction time distribution of fast decision tasks in schizophrenia: Evidence for novel candidate endophenotypes

Autor: Christoph Klein, Maida Toumaian, Ruth Tanti, Christos Theleritis, Christopher W. N. Saville, Nikolaos Smyrnis, Simon Fish, Eleni Pappa, Marina Economou, Timothy J. Davies

Publikováno v: Psychiatry Research. 269:212-220

Increased reaction time (RT) and variability of RT in fast decision tasks is observed in patients with schizophrenia and their first degree relatives. This study used modelling of the RT distribution with the aim of identifying novel candidate endoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42914e0aa9175a2dd52a3a0aba0ab83
https://doi.org/10.1016/j.psychres.2018.08.067

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Boosting Antitumour Immunity through Targeted Delivery of Interferon-α

Autor: Timothy J. Davies, Paul J. Fairchild

Publikováno v: Trends in Molecular Medicine. 25:935-937

Immune checkpoint inhibitors (ICIs) have revolutionised cancer immunotherapy but their success is wholly dependent on amplifying an existing immune response directed against the tumour. A recent study by Tsuchiya et al. suggests how the properties of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bc3a37ffb370ef21540295146f170e
https://doi.org/10.1016/j.molmed.2019.09.001

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