Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Timothy J, Allison"'
Autor:
Zhijian Zhao, Nathan R. Kett, Sujata Sharma, James C. Barrow, Robert F. Smith, Jeffrey W. Schubert, Nancy A. Sachs, Scott E. Wolkenberg, Ronald G. Robinson, Jeffrey Y. Melamed, Michael S. Poslusney, James Mulhearn, Pete H. Hutson, Scott T. Harrison, Dawn L. Hall, John M. Sanders, Timothy J. Allison, Sangita B. Patel
Publikováno v:
ACS Medicinal Chemistry Letters. 6:318-323
3-Hydroxy-4-pyridinones and 5-hydroxy-4-pyrimidinones were identified as inhibitors of catechol-O-methyltransferase (COMT) in a high-throughput screen. These heterocyclic catechol mimics exhibit potent inhibition of the enzyme and an improved toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0ee80fe9b95ccf26d22c6a22811b6f
https://doi.org/10.1021/ml500502d
https://doi.org/10.1021/ml500502d
Autor:
Timothy J. Allison, Christiana Fogg, Scott C. Garman, Bernard Moss, David N. Garboczi, Hua-Poo Su
Publikováno v:
Proceedings of the National Academy of Sciences. 102:4240-4245
Although eradicated from nature more than two decades ago, the threat of smallpox has reemerged because of concerns over its use as a biological weapon. We present the structure of the poxvirus L1 protein, a molecule that is conserved throughout the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b27e21df060b9495a4a24f3bc8f014e
https://doi.org/10.1073/pnas.0501103102
https://doi.org/10.1073/pnas.0501103102
Autor:
Deborah M. Briercheck, John P. Richardson, Gordon S. Rule, Todd C. Wood, Fraydoon Rastinejad, Timothy J. Allison
Publikováno v:
Nature Structural Biology. 5:352-356
Transcription termination factor rho is an ATP-dependent hexameric helicase found in most eubacterial species. The Escherichia coli rho monomer consists of two domains, an RNA-binding domain (residues 1-130) and an ATPase domain (residues 131-419). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c4cc0c02f065efb0cbe66e343f7b92
https://doi.org/10.1038/nsb0598-352
https://doi.org/10.1038/nsb0598-352
Autor:
Alan B, Northrup, Matthew H, Katcher, Michael D, Altman, Melissa, Chenard, Matthew H, Daniels, Sujal V, Deshmukh, Danielle, Falcone, David J, Guerin, Harold, Hatch, Chaomin, Li, Wei, Lu, Bart, Lutterbach, Timothy J, Allison, Sangita B, Patel, John F, Reilly, Michael, Reutershan, Keith W, Rickert, Craig, Rosenstein, Stephen M, Soisson, Alexander A, Szewczak, Deborah, Walker, Kevin, Wilson, Jonathan R, Young, Bo-Sheng, Pan, Christopher J, Dinsmore
Publikováno v:
Journal of medicinal chemistry. 56(6)
This report documents the first example of a specific inhibitor of protein kinases with preferential binding to the activated kinase conformation: 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 11r (MK-8033), a dual c-Met/Ron inhibitor under investigati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4116662dcbbe55aab9b82313c0024c89
https://pubmed.ncbi.nlm.nih.gov/23379595
https://pubmed.ncbi.nlm.nih.gov/23379595
Autor:
Christopher J. Penington, Srinivasan Raghunathan, Ronald J. Chandross, Gordon S. Rule, Robert H. Kretsinger, Timothy J. Allison
Publikováno v:
Journal of Molecular Biology. 238:815-832
The structures of three crystal forms of the class mu human glutathione transferase GSTM2-2 have been determined. X-ray phase information was obtained independently from molecular replacement and from anomalous scattering by a single isomorphous deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea5a5203a986944746033f48f88a5772
https://doi.org/10.1006/jmbi.1994.1336
https://doi.org/10.1006/jmbi.1994.1336
Autor:
Kevin J. Lumb, David Joseph Guerin, Stephen M. Soisson, Jennifer M. Shipman, Kevin J. Wilson, Rachael E. Ford, Jun Lu, Sanjeev Munshi, John C. Reid, Jonathon R. Young, Sangita B. Patel, Maria Kornienko, Elizabeth Stanton, Timothy J. Allison, Dawn L. Hall, Paul L. Darke, Keith W. Rickert, Noel Byrne
Publikováno v:
The Journal of biological chemistry. 286(13)
The receptor tyrosine kinase c-Met is implicated in oncogenesis and is the target for several small molecule and biologic agents in clinical trials for the treatment of cancer. Binding of the hepatocyte growth factor to the cell surface receptor of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ed4ab62eb2cae926d37593e2d4a5ac
https://pubmed.ncbi.nlm.nih.gov/21247903
https://pubmed.ncbi.nlm.nih.gov/21247903
Autor:
Sujata Sharma, Daria J. Hazuda, Jay A. Grobler, Youwei Yan, Hua-Poo Su, Christopher L. Daniels, Robert F. Smith, H. Marie Loughran, Pravien Abeywickrema, Timothy J. Allison, John C. Reid, G. Sridhar Prasad, Peter D. Williams, Paul L. Darke, Bei Xu, V V Sardana, Maria Kornienko, Sanjeev Munshi
HIV/AIDS continues to be a menace to public health. Several drugs currently on the market have successfully improved the ability to manage the viral burden in infected patients. However, new drugs are needed to combat the rapid emergence of mutated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa19d68bf7c1de7c52703e51ad8362dd
https://europepmc.org/articles/PMC2897604/
https://europepmc.org/articles/PMC2897604/
Autor:
Douglas R. Cary, Jennifer Wilkinson, Yafan Lu, Robert S. McDowell, Phuongly Pham, Jeffrey W. Jacobs, Wanli Lu, Melissa B Lam, Michael J. Romanowski, Beth Pietrak, Marcus Ballinger, Raymond V. Fucini, Jian Sun, David M Penny, Wenjin Yang, Timothy J. Allison, Mike Randal, Dennis Colussi, Anila E Thomas, Bruce T. Fahr, Kenneth E Lind, Sanjeev Munshi
Publikováno v:
Biochemistry. 48(21)
BACE-1 (beta-site amyloid precursor protein cleaving enzyme), a prominent target in Alzheimer's disease drug discovery efforts, was surveyed using Tethering technology to discover small molecule fragment ligands that bind to the enzyme active site. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad4f6a235db99ac7b282b393ed54e12
https://pubmed.ncbi.nlm.nih.gov/19284778
https://pubmed.ncbi.nlm.nih.gov/19284778
Autor:
Chandra J. Panchal, Craig A. Coburn, Timothy J. Allison, M. Katharine Holloway, Brent Richard Stranix, Joseph P. Vacca, Jinzi J. Wu, Serge Dandache, Mark A. Wainberg, Maureen Oliveira
Publikováno v:
Journal of medical virology. 80(12)
The development of new HIV inhibitors with distinct resistance profiles is essential in order to combat the development of multi-resistant viral strains. A drug discovery program based on the identification of compounds that are active against drug-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a945ccfab133deb20da1fd829d05a65
https://pubmed.ncbi.nlm.nih.gov/19040279
https://pubmed.ncbi.nlm.nih.gov/19040279
Autor:
Hong Zhu, Philippe G. Nantermet, Hemaka A. Rajapakse, Joseph P. Vacca, Eric A. Price, Dennis Colussi, Keith P. Moore, Jerome H. Hochman, Samuel L. Graham, Sethu Sankaranarayanan, Timothy J. Allison, Georgia B. McGaughey, Adam J. Simon, Nicole T. Pudvah, Sanjeev Munshi
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
This letter describes replacements for the P3 amide moiety present in previously reported tertiary carbinamine macrolactones. Although P-gp efflux issues associated with these amide-macrolactones were solved and full brain penetration was measured in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fb688dfa669144debafc169cebba9f
https://pubmed.ncbi.nlm.nih.gov/17827011
https://pubmed.ncbi.nlm.nih.gov/17827011